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Articles by A.D. Nageswari
Total Records ( 3 ) for A.D. Nageswari
  M.G. Rajanandh , A.D. Nageswari and K. Ilango
  Asthma is an inflammatory disease characterized by recurrent episodes of breathlessness and wheezing. Though inhaled corticosteroids play a vital role in the treatment of asthma, it alone or with long acting beta agonist cannot control asthma symptoms in most of the patients. The present study aims to assess the two controller medications in the form of oral tablets with inhaled corticosteroid combination in controlling forced expiratory volume in one second (FEV1) in mild to moderate persistent asthma patients. A total of 108 patients with mild to moderate asthma were enrolled in this randomized controlled study from the pulmonary medicine department of a tertiary care hospital. Patients were randomized into two groups viz., Group 1 (n = 54) and Group 2 (n = 54). Group 1 patients received Montelukast and Group 2 patients received Doxofylline. Both the groups received Budesonide inhaler. Pulmonary function test was assessed at the baseline and on follow up days. No significant difference was observed with respect to socioeconomic and educational status of patients between the groups. Significant (p<0.001) improvement in percentage predicted FEV1 after 120 days treatment was observed with both Montelukast and Doxofylline treated groups. There is no statistically significance between the groups. No major adverse events were found during the study period. The study concluded that both controller medications helped in improving lung function.
  M.G. Rajanandh , A.D. Nageswari and K. Ilango
  In many south Indian hospital, patient education by a clinical pharmacist is almost nil. The aim of this study was to assess the impact of patient education on Knowledge, Attitude, Practice (KAP) and Health Related Quality of Life (HRQoL) in asthmatics. The study also aimed to develop and validate the KAP questionnaire for asthma in south Indian set-up. Patients (n = 297) were educated on monthly basis for a period of 6 months using Global Initiative for Asthma recommended pocket guide. Impact of patient education was assessed by comparing the baseline and end visit KAP scores. On every follow-up visit, patient’s HRQoL was measured using Saint George Respiratory Questionnaire (SGRQ). The standardized cronbach’s alpha value was 0.81. The test-retest reliability was 0.89. A significant (p<0.05) improvement of KAP score was observed with respect to baseline characteristics. A significant improvement (p<0.05) in all the domains of the SGRQ score was observed from day 30 onwards. The developed KAP questionnaire was acceptable and culture fair in the tested population. Pharmacist provided patient education significantly improved patient’s KAP and HRQoL.
  A.D. Nageswari , Uday Kiran Gampala and M.G. Rajanandh
  Classification of severity of airflow limitation in Chronic Obstructive Pulmonary Disease (COPD) does not represent the clinical consequences of COPD. Hence, combined COPD assessment should be preferred. The BODE index has recently been proposed to provide useful prognostic information. The present study aimed to identify the best component in the assessment of severity in terms of BODE index and spirometry. A prospective comparative study was carried out with 70 COPD patients recruited over 10 months at the Pulmonary Medicine outpatient department of a tertiary care hospital in Tamilnadu, India. Patients were classified according to the GOLD classification of severity of airflow limitation after performing spirometry. The BMI, dyspnea, 6 min walking distance, FEV1 and BODE index was calculated for each patient. Patients were started on inhalation therapy and pulmonary rehabilitation and followed-up every fortnightly, after 2 months of the treatment, to repeat the BODE index and spirometry. Comparison was done between the FEV1 and BODE index before and after treatment. The mean FEV1 before the treatment was 51.00 (15.21) and after the treatment, it was 48.75 (14.92). There is no statistical difference found between pre and post treatment. However, the mean BODE index score before treatment was 5.47 (1.95) and after the treatment was 4.70 (2.35). With 95% confidence interval, the level of significance was 0.001. The present study concluded that, for the assessment of severity in COPD patients, BODE index helps in a better manner than FEV1 in response to medical intervention. Calculating BODE index is simple and needs no special equipment. This makes it a potential tool of potentially widespread applicability.
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