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Articles by A.A. Ebbo
Total Records ( 4 ) for A.A. Ebbo
  S.W. Hassan , R.A. Umar , A.A. Ebbo , A.J. Akpeji and I.K. Matazu
  Hepatoprotective activity of 50% ethanolic leaf extracts of Parkinsonia aculeata was evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. The extract at doses of 100, 200 and 300 mg kg-1 body weight were administered orally once daily. Hepatoprotective activity was measured based on biochemical parameters. Significantly (p<0.05) elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin (TB) and peroxide value in CCl4-intoxicated rats were restored to normal levels in the animals treated with the extract at doses of 100, 200 and 300 mg kg-1 and CCl4. The levels of total proteins, albumin, vitamins C and E appreciated significantly (p<0.05) in animals treated with different doses of the leaf extracts and CCl4. The effects were dose-dependant. These results suggest the leaf extracts of this plant to have potential therapeutic and preventive efficacies, probably due to its antioxidative effect.
  S.W. Hassan , R.A. Umar , Y.U. Dabai , A.A. Ebbo and U.Z. Faruk
  The aqueous and organic solvent leaves extracts of Pteridium aquilinum were screened for antibacterial activity by hole-in-plate bioassay procedure. The effect of aqueous leaves extract of the plant on hepatorenal functions in rabbits was also studied. Hexane (HX) fraction at 10 to 120 mg mL-1 did not show activity against Escherichia coli and Pseudomonas aeruginosa. However, it was significantly (p<0.05) active against Staphylococcus aureus at 90 and 120 mg mL-1. The chloroform (CHL) extract fraction at concentrations of 50-120 mg mL-1 was significantly (p<0.05) active on all the bacterial species. Petroleum ether (PE) at 10-120 mg mL-1 showed significant (p<0.05) inhibition of S. aureus and E. coli. Aqueous (W) extract exhibited significant inhibitory activity at 50-120 mg mL-1 on S. aureus and P. aeruginosa. Tannins, anthraquinone glycosides, cardiac glycosides, cyanogenic glycosides and volatile oils were detected in the extracts. The lethal dose (LD50) of the aqueous leaves extracts was found to be greater than 3000 mg kg-1 (p.o.) in rabbits. Non significant (p>0.05) and significant (p<0.05) changes in renal and liver indices, respectively were observed. Aqueous leaves extract of Pteridium aquilinum is toxic to the liver of rabbits only at 1500-3000 mg kg-1. These results have provided scientific evidence to justify the indigenous use of the plant against infectious diseases.
  S.W. Hassan , M. Lawal , B.Y. Muhammad , R.A. Umar , L.S. Bilbis , A.A. Ebbo and Y.U. Dabai
  The column chromatographic fractions of chloroform (CHL1, CHL2 and CHL3) root extracts of Boscia angustifolia were screened for antibacterial activity and phytochemical properties. CHL1 fraction was significantly active (p<0.05) at 5 to 60 mg L-1 on Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Streptococcus pneumoniae with Minimum Inhibitory Concentration (MIC) of 0.63 to 1.25 mg L-1. The active fraction (CHL1) revealed the presence of only alkaloids with Retention factor (Rf) value of 0.36. The active antibacterial agent in the most potent fraction (CHL1) was isolated and identified by thin layer chromatography (TLC) and phytochemistry. The CHL2 and CHL3 fractions did not show inhibitory activity at 5 to 60 mg L-1. The antibacterial activity of root extract of Boscia angustifolia is due to a chloroform-extractable compound. The results support the ethnomedicinal use of root of Boscia angustifolia for the treatment of bacterial diseases.
  S.W. Hassan , M. Lawal , B.Y. Muhammad , R.A. Umar , L.S. Bilbis , U.Z. Faruk and A.A. Ebbo
  The in vitro antifungal activity and phytochemical properties of column chromatography fractions of Hexane (HX), Petroleum Ether (PE) and Chloroform (CHL) of stem bark of Ficus sycomorus were studied. The bioactive agent in the most potent fraction with antifungal properties was isolated and identified by preparative Thin Layer Chromatography (TLC) and phytochemical analysis. The hexane fractions (HX2 and HX3) were significantly active (p<0.05) at 0.31 to 5.63 mg mL-1 on Microsporum gypseum, Aspergillus niger, Aspergillus flavus and Candida albicans. The fractions revealed the presence of Steroids (STR), Condensed Tannins (CDT), Cardiac Glycosides (CG) and Saponins (SAP). The HX4 fraction was the most potent, exhibiting complete inhibitory activity against all the fungal isolates tested. The fraction contained Anthraquinone Glycosides (ATG) with Retention factor (Rf) value of 0.87. All the PE fractions (PE1, PE2 and PE3) did not exhibit significant activity on the fungal isolates at 0.31 to 3.75 mg mL-1. The CHL fractions (CHL1 and CHL2) showed very high inhibitory activity on only Trichophyton mentagrophytes and Trichophyton rubrum. The phytochemical analysis of these fractions revealed the presence of CG, SAP, CDT and STR. The results of the present study add credence to the ethnomedicinal uses of Ficus sycomorus for the treatment of fungal diseases.
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