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Articles by A.A. Hismiogullari
Total Records ( 2 ) for A.A. Hismiogullari
  S.E. Hismiogullari , A.A. Hismiogullari , F. Sahin , E. Toksoy Oner , S. Yenice and D. Karasartova
  Organic acids are becoming more accepted as substitutes for antibiotics. The aim of this study was to determine the antibacterial effects of ascorbic acid, lactic acid and acetic acid and at the same time to analyze the cytotoxicity of these organic acids to mammalian cells. The antibacterial effects of ascorbic acid, lactic acid and acetic acid in Brain Heart Infusion (BHI), at 4, 1, 0.5, 0.25 and 0.1% concentrations, on the bacteria suspensions of Staphylococcus aureus ATCC29740 and Escherichia coli DH5a strains, were determined by dilution methods. The cytotoxic effects of organic acids in Dulbecco’s Modified Eagle’s Medium (DMEM) at 4, 1, 0.5, 0.25 and 0.1% concentrations on cell cultures of murine fibroblast NIH 3T3 cells, were analyzed by the 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) test. Antibacterial study showed that acetic acid was the most effective acid on both bacterial strains followed by lactic acid and ascorbic acid. Interestingly, although lactic acid was highly antibacterial, it produced the least cytotoxic effect on murine fibroblast cells. Acetic acid produced the strongest cytotoxic effect. At the same concentrations, the lowest pH values were measured in lactic acid containing media. It was followed by acetic acid. This study showed that the antibacterial and cytotoxic effects of organic acids may follow different mechanisms, on the other hand, pH changes caused by organic acids are not the only determining factor. Therefore, testing the cytotoxicity of organic acids on mammalian cells is usefull in preventing the detrimental effects of organic acids to the mammalian cells before using them as antibacterial agents.
  S.E. Hismiogullari , E. Elyurek , A.A. Hismiogullari , F. Sahin , M. Basalan and S. Yenice
  In order to assess the potential use of fatty acids and their derivatives as alternatives to the regionally banned antibiotics, the bacteriocidal and cytotoxic effects of caproic (hexanoic) and caprylic (octanoic) acids were investigated. Fatty acids at various concentrations were added to media containing Staphylococcus aureus, Escherichia coli and murine fibroblast cells. At 0.5% (w/v) concentration of  hexanoic acid, both S. aureus and E. coli growth occurred, however, octanoic acid was effective on inhibition of growth of both bacteria above 1% level. At the same time octanoic acid above 0.5%, hexanoic acid above 0.25% levels inhibited mammalian cell growth. Both acids decreased the medium pH linearly with increasing concentration. Further investigation is needed to prove that they may be usable for in vivo applications.
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