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Articles by A. Tibiri
Total Records ( 3 ) for A. Tibiri
  A. Tibiri , J.T. Banzouzi , A. Traore , G.O Nacoulma , I.P. Guissou and B. Mbatchi
  This study was aimed to assess the possible toxic effects of Entada africana, a widely used African medicinal plant. The acute toxicity of the methanolic stem bark and leaf extracts of Entada africana Guill. and Perr., (Mimosaceae) was assessed on mice. It revealed an average toxicity with a LD50 of 146.7 and 249.9 mg kg-1 body weight for stem barks and leaves, respectively. The extracts showed no cytotoxicity against KB and Vero cells. Sub-chronic toxicity was assessed in rabbits, which received orally, daily for a month, a dose corresponding to 10% of the LD50. Compared to the control group this dose caused no significant (p>0.05) modification of haematological and biochemical parameters, total cholesterol, urea, creatinine and aspartate amino-transferase (AST). The extracts lowered serum glucose significantly (p<0.05) by 52% at first two weeks of treatment. The stem bark and leaf extracts showed temporary decrease (p<0.05) of Alanine amino transferase (ALT) by 26.1 and 39.1%, respectively. The stem bark extracts increased triglycerides significantly (p<0.01) by 108% at the end of last week of treatment. These investigations seemed to indicate the safety ob sub-chronic oral administration (up to 14.67 and 24.9 mg kg-1 body weight) of the methanolic extracts of Entada africana in rabbits.
  A. Tibiri , O. Rakotonandrasana , G.O. Nacoulma and J.T. Banzouzi
  Dried ground leaves and barks of Entada africana were extracted by maceration in methanol and fractioned with chloroform, ethyle acetate and water. The total phenolic content of each fraction was determined spectrophotometrically according to Folin-Ciocalteu`s method and calculated as Tannic Acid Equivalent (TAE). Tannins and flavonoids were also determined. The total phenolic content was quite high, especially in the aqueous fraction (up to 39.7% TAE in the barks and 39.9% in the leaves). The antioxidant activity of lyophilized extracts was determined at room temperature by the means of the 2,2-diphenyl-1-picrylhydrazyl (DPPH!) colorimetric method with a detection scheme at 517 nm and expressed as EC50. The radical scavenging activity was evaluated as the difference in absorbance between a test sample and the control (methanol). Bark extracts had the best EC50, similar to those of rutoside and ascorbic acid for the aqueous and methanol fraction (5.7 and 5.3 μg mLG1, respectively). All the other extracts were moderately active (EC50 ranging from 6.9 to 20.0 μg mLG1), except the chloroform extracts (EC50 > 69 μg mLG1). Except for the crude and aqueous bark extracts, no extract was cytotoxic on KB or Vero cells.
  P.A.E.D. Sombie , A. Hilou , A.Y. Coulibaly , A. Tibiri , M. Kiendrebeogo and O.G. Nacoulma
  The purpose of the present study was to investigate the protective effects of the extracts against H2O2-induced hemolysis of erythrocytes and the neuroprotective potential from galls of Guiera senegalensis. Ethyl acetate fraction of aqueous decoction extract (EAF/ADE) significantly (p<0.05) inhibited lipid peroxidation in rat’s brain homogenate in vitro (37.79±0.93% at 1.25 mg mL-1) when compared to the gallic acid and quercetin used as positive controls and has the best anti-acetylcholinesterase activity (64.02±4.07% at 100 μg mL-1). Under the oxidative action of H2O2, the extracts from galls of G. senegalensis showed significant protection of the erythrocyte membrane from hemolysis. The Aqueous Decoction Extract (ADE) contains the highest amount of total tannin (25.3±1.55 mg TAE/100 mg of extract) content. The erythrocytes hemolysis inhibitory property from galls of G. senegalensis seems to be related weakly to its total tannin content (p<0.05). The present study thus suggested that the galls from G. senegalensis could be used as a new potential source of natural neuro-protective and antioxidant components.
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