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Articles by A. Pakfetrat
Total Records ( 3 ) for A. Pakfetrat
  Z. Delavarian , A. Pakfetrat , F. Falaki , M. Pazouki and N. Pazouki
  It seems that Oral Squamous Cell Carcinoma (OSCC) in young adults is different from OSCC in older patients especially in risk factors. No significant habits are seen in younger patients. It is claimed that viral infections, especially human papillomavirus, are associated with several human carcinomas, especially oral cancers. The aim of this study was to investigate the presence of viruses in Oral Squamous Cell Carcinoma (OSCC) in young patients (20-40 years old) attending Mashhad Dental Faculty from 1996 to 2009 for the first time in Iranian population. Twenty one formalin-fixed, paraffin-embedded sections of patients under 40 years with clinical diagnosis of OSCC, who had referred to Mashhad Dental Faculty from 1996 and 2009, were evaluated for DNA extraction. All specimens were tested for presence of Human papilloma virus, Epstein-Barr virus, Herpes simplex virus type 1 and Cytomegalovirus virus. From 21 specimens, viruses were detected only in three cases. Two samples were positive for EBV and the third one was co-infected with EBV and HSV-1. All of our specimens were negative for HPV and CMV. We concluded that viruses had no important role in OSCC in our young patients. Further researches are needed to clarify this role and to identify other possible risk factors.
  A. Pakfetrat , F. Falaki , M. Sankian and H. Abbaszadeh
  It was hypothesized that serum level of immunoglobulins may play a role in the pathogenesis of oral mucosal diseases but little is known about the role of salivary immunoglobulins in the pathogenesis of these diseases. The aim of this study was to investigate the possible alterations in salivary immunoglobulin A (IgA-s) level in patients with oral aphthous ulcers and its relation with clinical parameters. Level of IgA was measured by "ELISA" test in the resting whole saliva of 24 patients with acute Recurrent Aphthous Ulceration (RAU) and during remission and the results were compared with 24 healthy volunteers. IgA was increased in acute RAU in comparison with healthy controls. Results demonstrated a significant increase in salivary IgA level in active lesions in relation to quiescence phase. No differences were found in salivary IgA level between major and minor acute RAU and other clinical parameters. The results of our study suggest a possible role of mucosal immune system in the pathogenesis of these lesions. It is reasonable to postulate that modulation of salivary immune system in vivo or production of immune materials in vitro can be efficient in the prevention or control of aphthous lesions.
  Z. Dalirsani , M. Aghazadeh , M. Adibpour , M. Amirchaghmaghi , A. Pakfetrat , P. Mosannen Mozaffari , M. Mehdipour and A. Taghavi Zenooz
  The use of mouthwash has increased because of attention to oral hygiene. Herbal mouthwashes have fewer side effects and are more economic than similar chemical drugs. In this study, the antimicrobial effects of ten herbal extracts on Streptococcus mutans were compared with chlorhexidine. Thirty grams of ten plants including thyme, mint, garlic, cinnamon, chamomile, tea tree, clove, spearmint, sage, and rosemary were dissolved in 100 mm of pure methanol and placed on a shaker for 48 h. Then, after passing the solution through a filter, they were put in an incubator at 37 centigrade degee for 48 h. Streptococcus mutans was cultured on blood agar. Chlorhexidine discs were used as positive controls while methanol and blank discs were used as negative controls. After 24 h the diameters of the halos indicative of lack of growth in each disc were measured with a pair of calipers. The zone diameters around each disc were compared with chlorhexidine using T test analysis. The inhibitory zone has observed around the Rosemary extract discs. Rosemary was found as a potent antimicrobial plant. More studies are suggested for production of herbal mouthwashes.
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