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Articles by A. Ozgonul
Total Records ( 2 ) for A. Ozgonul
  Muhammet E. Guldur , A. Ozgonul , Ibrahim H. Kilic , O. Sogut , M. Ozaslan , M. Bitiren , M. Yalcin and D. Musa
  Cyperus rotundus (CR) is widely used as a traditional folk medicine for treating various diseases such as gastrointestinal disorders, inflammatory and infectious diseases in Middle Eastern countries. However, the protective effects of CR extract on gastric mucosa has not been well defined. Thus, the aim of the present study was to investigate the protective effects of CR on gastric mucosal damage induced by ischemia and reperfusion in rats. Ischemia/reperfusion model was designed as of 30 min ischemia followed with 60 min reperfusion by clamping the celiac artery. The CR extracts were given at the doses of 100 or 200 mg kg-1 for preventing postischemic gastric mucosal injury. The study was carried out on equal five groups (n = 6) namely as follows: group I (sham, control group), group II (untreated ischemia control group), group III (treated ischemia group) was treated with 200 mg kg-1 CR, group IV (treated ischemia group) was treated with 100 mg kg-1 CR and group V (treated ischemia/reperfusion group) was treated with 200 mg kg-1 CR. Antioxidant enzymes activity such as Malondialdehyde (MDA) and glutathione-peroxidase (GSH-Px) were measured in the gastric tissue. Histopathological sections were examined for ischemic injury. The mean ulcer index of rats treated with 200 and 100 mg kg-1 CR were significantly lower (p<0.05) than that of control rats. The activities of GSH-Px and MDA were significantly affected (p<0.05) by treatment of CR in group III and group IV. These results indicate that both doses of CR extract have gastroprotective effect against acute gastric mucosal lesions induced by ischemia/reperfusion.
  M. Bitiren , D. Musa , A. Ozgonul , M. Ozaslan , A. Kocyigit , O. Sogut , Muhammet E. Guldur , I.H. Kilic , Ali Z. Karakilcik and M. Zerin
  The present study was planned to investigate the protective effects of herbal methanol extracts of Hypericum perforatum (HP) and Urtica dioica (UD) and herbal agueous extract of Camelia sinensis (CS)-containing antioxidants on carbon tetrachloride (CCl4)-induced hepatic injury and lymphocyte DNA damage. Adult male albino rats (n 50) were separated into five groups of ten each, as follows: control group; CCl4 group; CCl4+HP extract group; CCl4+UD extract group; CCl4+CS extract group. All extract groups were fed with 200 mg kg-1 extracts of HP, CS and UD, respectively once every alternate day for 7 weeks. CCl4 injections were applied to the CCl4 and extract groups at the dose of 0.4 mL kg-1. Malondialdehyde, total oxidant status and total antioxidative capacity levels and catalase, superoxide dismutase and glutathione peroxidase activities were significantly changed in the CCl4 group and indicated increased oxidative stress. The DNA damages detected via commet assay were significantly higher than in the CCl4 group. Treatment by extracts of HP, CS or UD were significantly decreased this oxidative stress and ameliorated lymphocyte DNA damage. These results indicate that the herbal extracts of HP, UC and CS have beneficial effects on liver and lymphocyte DNA damage induced by CCl4 probably due to their antioxidant properties.
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