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Articles by A. Muthuraman
Total Records ( 2 ) for A. Muthuraman
  S. Sood , A. Muthuraman , N.S. Gill , M. Bali and P.D. Sharma
  The present study was designed to evaluate the antioxidant and anti-ulcerogenic potential of Citrus karna peel extract. Extraction of Citrus karna peels was carried out using different solvents. Phytochemical screening and evaluation of antioxidant activity of all the extracts were carried out. Further, anti-ulcerogenic activity of ethyl acetate extract of Citrus karna peels (EtCK) was assessed in water immersion (WIS) and hypothermic restraint (HRS) stress models at different doses (200, 300 and 400 mg kg-1). EtCK showed ulcer protective effect in both models in a dose dependent manner, which was indicated by decrease in the ulcerative index and thiobarbituric acid reactive species (TBARS) level in the blood and gastric tissue samples as compared to the disease control group. Moreover, antioxidant markers i.e., reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in the blood and tissue samples were found to be significantly increased in medium and high doses of EtCK (300 and 400 mg kg-1) treated groups similar to that of ranitidine treated group. The present study concluded that EtCK has a significant anti-ulcer effect at a dose level of 300 and 400 mg kg-1. Hence, it may be considered as a useful herbal therapeutic agent for the treatment of peptic ulcer disease.
  S. Sood , S. Bansal , A. Muthuraman , N.S. Gill and M. Bali
  In this study, we planned to evaluate the antioxidative, anti-inflammatory and analgesic potential of Citrus medica peel extract. Antioxidant activity in different solvent systems was evaluated. Ethyl acetate extract of Citrus medica peel (EtCM) showed maximum 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydrogen peroxide radical scavenging activity in a dose dependent manner as compared to ascorbic acid. Further, anti-inflammatory and analgesic activities of EtCM (200, 300 and 400 mg kg-1) were studied on carrageenan induced inflammatory pain in rats. Anti-inflammatory activity was assessed by measuring paw volume in rats. Analgesic activity was evaluated for its central and peripheral pharmacological actions by using hot plate, plantar, pin prick and mechanical allodynia tests in rats. EtCM (400 mg kg-1) produced significant decrease in paw volume and pain as compared to diclofenac. Therefore, the Citrus medica peel extract may be used as a future antioxidant for the treatment of inflammation and pain.
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