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Articles by A. Mazooji
Total Records ( 2 ) for A. Mazooji
  A. Eidi , M. Eidi , P. Shahmohammadi , V. Mozaffarian , A. Rustaiyan and A. Mazooji
  Herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. Salvia verticillata L. was investigated for its possible antidiabetic effect in normal and streptozotocin-induced diabetic rats. The animals were made diabetic using by streptozotocin (70 mg kg-1, i.p.). The ethanolic extract (0.05, 0.1 and 0.2 g kg-1) were administered orally. The control groups were administered saline. Oral administration of ethanolic extract of Salvia verticillata aerial parts for 14 days on the level of serum glucose, total cholesterol, triacylglycerol, urea, uric acid, creatinine, aspartate aminotransferase and alanine aminotransferase in normal and streptozotocin-induced diabetic rats were evaluated. At the end of the experiment, rats were fasted overnight and blood samples were collected. A comparison was made between the action of extract and a standard antidiabetic drug, glibenclamide. Oral administration of 0.05, 0.1 and 0.2 g kg-1 b.wt. of the ethanolic extract of Salvia verticillata aerial parts for 14 days exhibited a significant reduction in serum glucose, total cholesterol, triglycerides, urea, uric acid, creatinine, aspartate aminotransferase, alanine aminotransferase and increased plasma insulin in diabetic rats. It also prevents body weight loss in diabetic rats. The administration of extract did not change these serum parameters in normal rats. The antidiabetic effect of the extract was similar to that observed with glibenclamide. So, our study revealed the anti-diabetic potential of Salvia verticillata and this study could be helpful to develop medicinal preparations for diabetes and related symptoms.
  A. Eidi , M. Eidi , V. Mozaffarian , A. Rustaiyan , A. Mazooji , Z. Khaboori and F. Nabiuni
  The aim of this study was to evaluate the antinociceptive and anti-inflammatory effect of Salvia syriaca L. aerial parts ethanolic extract in male NMRI mice. Antinociceptive activity was done using by formalin, hot plate and writhing tests. The effect of ethanolic extract on acute inflammation was studied by xylene edema test in mice. The Salvia syriaca L. ethanolic extract (1, 10, 50 and 100 mg kg-1 body wt.) was injected intraperitoneally. The control group administrated with saline. Present results showed that the ethanolic extract decreased only second phase of formalin-induced pain. In hot plate test, the ethanolic extract did not raise pain threshold during 60 mins. The ethanolic extract exhibited antinociceptive activity against writhing-induced by acetic acid. In xylene ear edema test, Salvia syriaca L. ethanolic extract showed significant activity in the mice. The present data indicated that this plant has antinociceptive and anti-inflammatory effect on the mice but more works are required to be done in order to elucidate the mechanism (s) involved in antinociceptive and anti-inflammatory effects of the Salvia syriaca L. extract.
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