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Articles by A. Islam
Total Records ( 9 ) for A. Islam
  A. Sarwar , M.S. Rahman , T.B. Huq , K. Biswas , M.I. Hussain , J.F. Chaity , T. Begum , Md. E. Haque , A. Islam and Mst. M. Begum
  Background and Objective: To compare the prevalence of acute vomiting between patients receiving cisplatin as monotherapy or cisplatin in a combination regimen. Materials and Methods: The study was conducted at Delta Hospital Dhaka on a total of 70 patients (44 male and 26 female). The patients received either cisplatin alone or cisplatin with the following chemotherapeutic agents-docetaxel and 5 fluorouracil, docetaxel, etoposide, doxorubicin and capecitabine. The study was conducted in patients receiving chemotherapy for a total of the first 3 cycles. The patients were told to record the number of episodes of vomiting they experienced during the first 24 h after chemotherapy at each cycle. All 70 patients received prechemotherapy antiemetics a combination of 5HT3 receptor antagonist (ondansetron or palanosetron) and dexamethasone prior to chemotherapy. Results: In patients receiving the combination chemotherapy of cisplatin+docetaxel+5 FU experienced the lowest incidence of acute vomiting and cisplatin+capecitabine receiving patients experienced highest incidence of acute vomiting. All the other combination therapy resulted in emesis comparatively similar to that of cisplatin. In all the regimens except for cisplatin+etoposide the percentage of patients experiencing acute vomiting reduced along with progressive cycles. Conclusion: When cisplatin is given in combination regimen except for the combination regimen of cisplatin+capecitabine there is no significant increase in emesis between patients receiving cisplatin alone or in combination therapy.
  A. Islam , M.S. Islam , M.U.M.A. Zakaria , S.C. Paul and A.A. Mamun
  Background and Objective: Shrimp and prawn industries generate a huge amount of co-products (CPs) that can be utilized as a key source of chitin and chitosan, natural multifunctional polymers. The current study modified the existing extraction methods to produce chitin and chitosan from shrimp and prawn co-product (shell). Materials and Methods: Two improved methods (M1 and M2) with sub-sets (TA, TB, TC) were executed through chemical processes comprising demineralization, deproteinization and deacetylation maintaining different conditions. Chitin and chitosan were extracted by using different concentrations of HCl (1, 1.25 and 1.5 M) in the demineralization step. The purity of chitosan was tested by the ash content, moisture content, solubility test and biuret test. Results: Among the sub sets M2 TB and M2 TA produced higher amounts of chitosan from shrimp and prawn shell, respectively. The yield of the chitin and chitosan were higher in M2 than M1 for both species. M2 method found almost two times faster in time and comparatively pure and commercially standard than M1. The improvised method M2 seems to time sparing and efficient than the existing methods. Conclusion: Productions of chitosan from co-products will reduce the dependency on import for chitosan and may create employment and, exporting opportunities.
  A. Islam , A.J.M.S. Karim , H.M. Khaled , B.K. Mitra and M.A.M. Miah
  A study was conducted with four soils samples (0-15 cm) collected from different levels of arsenic (As) contaminated area where arsenic contaminated irrigation water from shallow tube well was used for rice cultivation to determine the maximum adsorption capacity, energy of adsorption and buffering capacity of As. Arsenic was determined by a Perkin-Elmer Aanalyst 100 atomic absorption spectrophotometer equipped with a FIAS-100 flow injection hydride generation system. The test soils showed a large capacity of arsenic adsorption. The application of arsenic progressively increased the equilibrium solution concentration of arsenic. At the lower levels of equilibrium concentration, the adsorption of arsenic linearly increased, but at greater levels of equilibrium solution concentration the rate of As adsorption decreased. Conventional adsorption equations-Langmuir, Freundlich and Temkin equations were used to describe arsenic sorption characteristics of soils. All soils were found to fit well in all the equations (R2 = 0.9052 to 0.9974). Highest and lowest adsorption maxima were observed 2000 mg kg-1 in soil 2 and 3 and 1111 mg kg-1 in soil 4 respectively. The highest and lowest arsenic buffering capacity were observed 405 in soil 2 and 185 in soil 4 respectively. The highest energy of adsorption obtained for the soil 4, which showed lowest arsenic adsorption maxima and the lowest energy of adsorption obtained with soil 2 followed by soil 3, which showed the highest arsenic adsorption maxima. Arsenic buffering capacity was positively correlated with the maximum adsorption capacity of the soils (r = 0.99). The As adsorption parameters were highly correlated with clay content, FeO and MnO content of the soils and not with the total As content of the soils.
  A. Islam , M.S. Hossain , A. Sayeed , Md. Ibrahim , H. Mondal and N. Absar
  The experiment was performed in the experimental land of the Institute of Biological Sciences, Rajshahi during the period of April-May, 2007 and 2008. The physical and chemical characteristics of jute fibre under different foliar treatments were investigated at mature stage. The results showed significantly increase in most of the chemical composition under different foliar treatments. Moisture content, dry matter and ash contents of jute fibre obtained from experimental land compared to those of control jute fibre after application of NPK-fertilizers and cowdung in combination with foliar spray. The moister content of jute fibre decreased whereas ash content increased significantly under different treatments. The moisture and ash contents of jute fibre were varied between 12 to 14% and 0.5 to 0.7%, respectively. On the other hand the dry matter content of jute fibre increased slightly under different treatments. The aqueous extract, fatty and waxy matter, pectic matter, α-cellulose, hemicellulose, lignin contents and tensile strength of jute fibre as compared to those of control were as follows: The maximum increase of aqueous extract 20.65% (treatment T2), the maximum increase of fatty and waxy 22.54% (treatment T2), pectic matter 5.49% (treatment T6), α-cellulose 61%, hemicellulose 29%, lignin contents 7.29% (treatment T6) and tensile strength 15.55%.
  M.S. Hossain , M.R.I. Khan , A.S.M. Anisuzzaman , M. Ahmed , M.S. Amran and A. Islam
  Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. The antihyperglycemic activity of leaves of Mangifera indica was evaluated with scientific approaches. The study was undertaken to investigate the antihyperglycemic, Oral Glucose Tolerance Test (OGTT) and glycogenesis effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of Mangifera indica. The different extracts were administered intraperitoneally as a single dose of 150 mg kg-1 b.wt. to normal, glucose induced and alloxan induced diabetic rats and found to reduce blood glucose level significantly (p<0.05). Beside these, the different fractions of Mangifera indica to the alloxan-induced diabetic rats resulted in the significant elevation of liver glycogen content which was decreased by 50.60% in diabetic control. The effects of plant extracts were compared with standard drug metformin. The phytochemical screening tests indicate the different constituents such as triterpines, alkaloids, flavonoids etc. are present in the plant which have the antidiabetic property. Thus, this investigation paves the way for plant based diabetic treatment and indicates that various fractions (Petroleum ether, ethyl acetate and chloroform) of the ethanolic extract of Mangifera indica have favorable effect in bringing down the severity of diabetes as well as increase glycogenesis activity by increasing the cellular uptake of glucose.
  M.S. Hossain , M.B. Alam , N.S. Chowdhury , M. Asadujjaman , R. Zahan , M.M. Islam , M.E.H. Mazumder , M.E. Haque and A. Islam
  The present study was designed to investigate the antioxidant, analgesic and anti-inflammatory potential of the methanolic extract along with its organic soluble fractions of the herb Eclipta prostrata. In addition, total phenolic and flavonoid content and total antioxidant capacity were also determined. Antioxidant potential of the extract/fractions was evaluated by DPPH (1,1diphenyl-2-picrylhydrazyl), NO (nitric oxide) and ONOO¯ (peroxynitrite) scavenging assay method. Ethyl acetate fractions (EtOAc) showed highest scavenging activity in all the methods with IC50 value of 12.98±0.08, 45.98±0.07 and 14.45±0.18 μg mL-1 for DPPH, NO and ONOO- assay method, respectively. In reducing power assay, EtOAc fraction also showed significant (p<0.001) activity. Further, the extract/fractions were studied for their analgesic (hot plate, tail immersion and acetic acid induced writhing test) and anti-inflammatory (carrageenan induced paw edema in rats) activities at a dose level of 200 and 400 mg kg-1 body weight. Among all the extract/fractions, EtOAc fraction showed a dose dependent and significant (p<0.005, p<0.05) analgesic activity in all the tested method. EtOAc fractions also reduced the paw edema considerably (86.80% inhibition after 3 h, p<0.005, p<0.05) in dose dependent manner compared to carrageenan induced rat. Altogether, these results suggest that the MeOH extract and its organic soluble fractions could be used as a potential antioxidant, analgesic and anti-inflammatory agent.
  Mst. M. Begum , M.S. Rahman , R.R. Swarna , M. Das , A.H.M.R. Imon , I. Jahan , M. Rahman , Md. E. Haque , R.R. Saha , A.H.M. Quamruzzaman , Md. A. Obaida , M. Maniruzzaman , A. Islam , Md. T. Islam and A. Sarker
  Background and Objective: Combination of dosages regimen of an antidiabetic agent (Glibenclamide) with a lipid lowering drug can be an effective medication for the patient with high blood glucose level and liver enzyme disfunctionality. The present study was undertaken to investigate the effect of a fixed dose combination of glibenclamide (1.2 mg/70 kg b.wt.) and simvastatin (10 mg/70 kg b.wt.) on blood glucose and liver enzymes dysfuntionality in alloxan-induced diabetic rats for an extended time period. Materials and Methods: Two protocols were developed to carry out the experiment. The first is designated as 4 weeks short-term and second one is termed as 12 weeks long-term treatment protocols, respectively. Diabetes Mellitus (DM) was induced by single intraperitoneal (i.p.) injection of freshly prepared alloxan solution in 0.9% saline. Diabetic rats received treatment with i.p., injection of glibenclamide (1.2 mg/70 kg b.wt.) and simvastatin (10 mg/70 kg b.wt.) for 4 weeks as monotherapy and combination therapy (glibenclamide 0.6 mg/70 kg b.wt., simvastatin 5 mg/70 kg b.wt.) for 12 weeks. Graph pad was used and the results were expressed as Mean±SEM. A one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc test or students paired or unpaired t-test was used in the study where appropriate. Results: Results were considered to be significant when p-values were less than 0.05 (p<0.05). Combination therapy demonstrated a significant (p<0.05) decrease in blood glucose and liver enzymes elevation compared with diabetic control group. The study also demonstrated that the short term treatment has satisfactory effect on lowering SGPT by 41% and SGOT by 50%. Long term administration of combination therapy showed more significant (p<0.05) potentiality on lowering SGPT (46%) and SGOT (53%), respectively and this level remain steady during total treatment period. Conclusion: The present study demonstrates that combination of glibenclamide with simvastatin at the dose level tested exhibits significant glucose and liver enzymes lowering activity in alloxan induced diabetic rats. When monotherapy with oral antidiabetic agents fails, combination therapy with glibenclamide plus simvastatin seems to be stable and effective for the treatment of diabetes mellitus.
  A. Tabassum , R.R. Saha , M.S. Rahman , M.A. Nure , R. Karim , A.H.M.R. Imon , M. Maniruzzaman , A.K.L. Kabir , A. Islam , J.F. Chaity , B.C. Adhikary , A. Sarwar , T.B. Huq and Mst. M. Begum
  Background and Objective: Pain management has been an area of a great deal of attention for pharmacists for many years. In this study, we report a study which is designed to investigate how a combination of existing effective drugs performs for the relief of pain management. Materials and Methods: A combined solid dosage containing paracetamol (500 mg) and ibuprofen (150 mg) is developed and tested under an observational analytical study. The performance of this combined oral solid dosage named maxigesic tablet in order to reduce pain is investigated on the basis of European patent specification. This assay is carried out by employing HPLC system with UV detection at 222 nm. Results: The results show the presence of active components to the tune of 112.12% for paracetamol and 101.86% for ibuprofen. The formulated solid dosage is further subjected to separate groups of artificially pain induced mice for a comparative study and it shows more efficacy than single analgesic used in pain management. We observe that the respective potencies for paracetamol and ibuprofenare 98.57 and 102.90%. Conclusion: The characterization of both granules and tablets of newly developed formulation demonstrates significant improvement in results of analytical test that not only met the standard specification, but they also reveal that the combined dosage will improve the product quality, efficacy and patient safety in the long run. This trial also shows a significant difference in the percentage of pain inhibition between the two sets of formulations (single and combination of them).
  M.A. Rahman , N. Islam , A. Islam , M.K. Hassan and M.M.R. Talukder
  A field experiment was conducted at the Regional Agricultural Research Station of Barisal, Bangladesh during the Kharif season of the year 2000 to find the optimum fertilizer rate for summer mungbean cv. Barimung-4 in an attempt to maximize the yield potential. In this regard, various combinations of NPK fertilizers and Rhizobium inoculation (N20P40K20 kg ha–1, P40K20 kg ha–1, N20K20 kg ha–1, N20P40 kg ha–1, N20 kg ha–1, Rhizobium + P40K20 kg ha–1, Rhizobium, and control) were imposed to the experimental plots. Results revealed that Barimung-4 produced the maximum seed (1270.21 kg ha–1) and straw yields (2434.36 kg ha–1) when the crop was fertilized with N20P40K20 kg ha–1 followed by Rhizobium + P40K20 kg ha–1 (1220.30 and 2406.14 kg ha–1, respectively. The lowest seed and straw yields were obtained from the control (887.01 and 1864.68 kg ha–1, respectively). Different plant characteristics such as plant height, branches/plant, pods/plant, pod length, seeds/pod, 1000-seed weight and harvest index increased significantly due to the application of various combinations of NPK fertilizers and Rhizobium inoculation over the control.
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