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Articles by A. Fadlelmula
Total Records ( 4 ) for A. Fadlelmula
  M.S. Shathele and A. Fadlelmula
  Three types of common and one commercial antifungal drugs were tested in vitro for assessing their effectiveness against dermatophytic fungi Trichophyton verrucosum using a microdilution assay of the NCCLS (M38-P) standard for filamentous fungi with slight modifications. Four agents of antifungal drugs in different concentrations defined as local mixture [consisting of cupric sulfate and calcium oxide (quicklime) by a mixture proportion of 1:1 in concentration of 80.0 mg mL-1], Hydrogen Peroxide mixture in concentration of 180.0 mg mL-1, 10% Formaldehyde mixture in concentration of 39.0 mg mL-1 and Amphotericin B (AMB) in concentration of 2.0 mg mL-1. The results showed that there is a discrepancy among the antifungal drugs on the impact of dermatophytic fungi Trichophyton verrucosum. The order of effectiveness of four antifungal drugs against dermatophytic fungi was AMB with a Minimum Fungicidal Concentration (MFC) (MFC90% = 2.0 μg mL-1)> 10% Formaldehyde mixture with a concentration of (MFC90% = 3.9 μg mL-1)> Hydrogen Peroxide mixture with a concentration of (MFC90% = 18.0 μg mL-1)> the local mixture with a concentration of (MFC90% = 80.0 μg mL-1). In conclusion, AMB with a Minimum Fungicidal Concentration (MFC) (MFC90% = 2.0 μg mL-1) is the most effective drug against dermatophytic fungi under the climatic condition of AL-Ahsa, Saudi Arabia.
  M.S. Shathele , A. Fadlelmula , F.A. Al-Hizab and M.M. Zaki
  A laboratory study was carried out to investigate fatal aspergillosis in an ostrich (Struthio camelus) predisposed by pulmonary haemangioma in the Kingdom of Saudi Arabia. The examination of Post Mortem (PM) revealed numerous ulcerated (1x0.5 cm) subcutaneous opaque thick masses with turbid materials (exudates) in the cut section together with fibrosis in between air sacs and the thoracic wall. The microscopic appearance indicated the presence of capillary type haemangioma in ostrich. The proliferating cells were highly differentiated, uniform with spindle-shaped nuclei resembling normal vascular endothelia and were arranged in the form of numerous capillaries distended with large amounts of blood erythrocytes and separated by fibrous stroma. However, large vascular spaces lined by a single layer of endothelium were also observed. The superficial parts of the tumour showed hyperkeratosis of the epidermis and diffuse infiltration of lymphocytes in the interstitial areas. In addition, the fibrous stroma was more abundant and dense with more prominent collagen in the peripheral parts of the tumour. On PM, the tiny yellowish white foci were detected on the lung’s specimens and yielded A. fumigatus in pure culture. The histopathologic examination of the lesions showed fungal hyphae, inflammatory and multinucleate giant cells.
  M.S. Shathele , A. Fadlelmula , F.A. Al-Hizab and M.M. Zaki
  M.S. Shathele and A. Fadlelmula
  The objectives of this study were to determine the suitability of transport medium (ice jells) and estimate the duration of viability of Pseudomonas in the transport medium. Bacteria of the genus Pseudomonas comprise a large group of the active biocontrol strains as a result of their general ability to produce a diverse array of potent antifungal metabolites. These include simple metabolites such as 2,4-diacetylphloroglucinol, phenazine-1-carboxylic acid and pyrrolnitrin [3-chloro-4-(2-nitro-3-chlorophenyl)-pyrrole], as well as the complex macrocyclic lactone, 2, 3-de-epoxy-2, 3-didehydro-rhizoxin. Pyrrolnitrin is active against Rhizoctonia sp., Fusarium sp. and other pathogenic fungi and it has been used as a lead structure in the development of a new phenylpyrrole fungicide. The survival rates of four different pseudomonad strains after continuous incubation for 4 h in the cold temperature (4°C) were: 94.8% for P. putida strain CBD, 94.5% for P. aeruginosa No. BRCH and 62.1% for Pseudomomas species (fluorescent) with lowest survival rate of 33.5% for P. aeruginosa strain H. Since, there were no drastic reductions in the survival rates, the study findings suggest that the transport medium would be generally suitable for these cold-sensitive bacteria.
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