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Articles by Ziba Rajaei
Total Records ( 2 ) for Ziba Rajaei
  Ahmad Ghorbani , Mousa-Al-Reza Hadjzadeh , Ziba Rajaei and Seyed Bamdad Zendehbad
  Several studies support hypolipidemic effect of fenugreek in normal and diabetic subjects. However, very little is known about the possible direct action of fenugreek on adipose tissue. The present study was designed to investigate the effects of fenugreek seeds on adipogenesis and lipolysis. Preadipocytes were isolated from adipose tissue of normal rats and differentiated to adipocyte in the presence of ethanolic extract of fenugreek seeds. The effect of this extract on lipolysis was also evaluated in fat tissue isolated from diabetic rats. Fenugreek led to a significant reduction in lipid droplet accumulation as evaluated with Oil Red O staining. Incubation of preadipocytes with the extract for 24 h resulted in significant decrease in cell viability. The extract, even at high concentrations (up to 1000 μg mL-1), had virtually no significant effect on lipolysis. The present data demonstrated that fenugreek seed inhibits formation of new differentiated adipocytes from precursor cells through an anti-proliferative effect on preadipocytes.
  Somayeh Shafiee , Alireza Ebrahimzadeh , Ziba Rajaei , Nema Mohammadian , Azam Alavinezhad , Shahrzad Havakhah , Sara Hossienian , Samira Shahraki and Abolfazl Khajavi Rad
  Cisplatin (cis-dichlorodiamineplatinum II) is a potent antineoplastic agent against several types of tumor. Nevertheless, its clinical utility is limited due to its cytotoxic adverse effects that include nephrotoxicity. Several factors including inflammation, oxidative stress, DNA damage and mitochondrial injury are involved in cisplatin-induced cell injury. Nigella sativa and vitamin E possess the anti-inflammatory and antioxidant properties. Accordingly, the present study was designed to investigate the protective effects of hydroalcoholic extract of Nigella sativa seeds and vitamin E on cisplatin-induced nephrotoxicity. Forty eight male Wistar rats were randomly divided into 8 groups and treated daily with Nigella sativa extract (100 or 200 mg kg–1, i.p.) or vitamin E (100 mg kg–1, i.p.) 1 h before single dose cisplatin injection (6 mg kg–1, i.p.) and continued for 5 days. Serum and urinary biochemical parameters were measured on day 0 and 6. Histopathological examination of the kidney and determining the kidney index were performed on day 6. The results showed that serum urea and creatinine concentrations, as well as urine glucose, kidney index and histopathological damage were significantly increased in cisplatin group compared with control group, while Glomerular Filtration Rate (GFR) and urea clearance were significantly reduced. Similar alterations in biochemical factors were observed in groups that received cisplatin together with Nigella sativa extract or vitamin E compared to control group. However, treatment with Nigella sativa extract or vitamin E could improve histopathological damages due to cisplatin. In conclusion, Nigella sativa extract or vitamin E treatment attenuated the histological alterations induced by cisplatin.
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