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The present study was designed to determine the effects of resveratrol supplementation on exercise-induced apoptosis of rat hepatocytes. The rats were divided randomly into the sedentary group (Group I) and exhaustive exercise groups (Group I-IV). Each group contains 12 animals. The rats of exhaustive exercise groups received daily oral administration of resveratrol at doses of 0, 200 or 400 mg/kg/day for 30 days. The rats of sedentary group received daily oral administration of vehicle only (10 mL/kg/day) for the same period. Exhaustive exercise was performed on a motor-driven rodent treadmill. Paraffin-embedded liver sections were stained using the Streptavidin Peroxidase (SP) immunohistochemistry technique for BAX and Bcl-2 detection. The results showed that exhausting exercises could make the expression of BAX proteins in the liver and BAX/Bcl-2 ratio dramatically increases, the expression of Bcl-2 proteins obviously decreases. After resveratrol supplementation, the expression of BAX proteins and BAX/Bcl-2 ratio obviously decreased, the expression of Bcl-2 proteins obviously increased. Which indicated that resveratrol supplementation can inhibit exercise-induced apoptosis of rat hepatocytes.
Tao-Hong-Si-Wu-Tang (THSWT) is a famous traditional Chinese herbal medicine formula which has traditionally been used in China for about 1000 years. The previous studies have shown that THSWT had anti-fatigue effects but the mechanisms are scanty. The present study was designed to evaluate anti-fatigue mechanisms of THSWT through determining the change of glucose and lipid metabolism. The rats were randomly divided into four groups: Sedentary Control group (SC); Exercise Control group (EC): Sedentary plus THSWT Treated group (STT) and Exercise plus THSWT Treated group (ETT). Rats in the STT and ETT groups received 20 mL kg-1 BW of THSWT solutions. After 28 days, rats in the EC and ETT groups were forced to swim for 90 min with a load (5% BW). The results showed that THSWT could improve blood glucose levels of rats during exercise as well as increase the liver and muscle glycogen contents while decreasing the plasma Free-Fatty Acid (FFA) levels. The anti-fatigue mechanisms of THSWT might be related to the improvement in the metabolic control of exercise and the activation of energy metabolism.
