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Articles by Zi Wang
Total Records ( 4 ) for Zi Wang
  Li-Chun Zhao , Ying Liu , Zi Wang , Nong Tang , Jing Leng , Bing Zheng , Ying-Ying Liu and Wei Li
  Background and Objective: Platycodi Radix (PR), a famous traditional medicine and folk food, has been used in China. PR exerted numerous pharmacological activities including anti-tumor, anti-obesity and anti-inflammation. The present study aimed to investigate the active constituents by Liquid Chromatography/Mass Spectrometry (LC/MS) analysis and protective effects of saponins from the steamed Platycodi Radix (SSPR) on acute alcohol-induced liver injury in mice. Materials and Methods: Pretreatment with SSPR (100, 200 and 400 mg kg–1) prior to alcohol administration significantly prevented the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride (TG) in serum, malondialdehyde (MDA) level in liver tissue compared with the alcohol group (p<0.05). Results: The level of enzymatic antioxidants glutathione (GSH) was increased noticeably (p<0.05) in SSPR pretreatment mice liver tissue. Histopathological examination revealed that pretreatment with 400 mg kg–1 of SSPR markedly ameliorated acute alcohol-induced hepatocyte apoptosis and fatty degeneration. The findings from LC/MS analysis indicated that SSPR had more saponins than unheated-processed one and SSPR mainly contain a polyacetylene (Lobetyolin) and 22 saponins. Conclusion: These results showed the beneficial effect of SSPR on acute alcohol-induced oxidative stress and liver damage.
  Ge Yang , Zi Wang , Shen Ren , Xiao-tong Yan , Xing-yue Xu , Jun-nan Hu , Yan Zhang and Wei Li
  Background and Objective: Acetaminophen (APAP)-induced hepatotoxicity is a severe public health problem in western countries. Current treatment methods for poisoning are limited and novel therapeutic strategies are needed. The aim of the present study was to investigate the protective effect of ginsenosides from the fruits of Panax ginseng (GFG)against APAP-induced liver injury in mice and its potential molecular mechanisms of action. Materials and Methods: In this study, mice were orally administered with 150 or 300 mg kg–1 of GFG for 7 consecutive days, followed by a single injection of APAP (250 mg kg–1). Severe liver injury was observed after 24 h APAP injection and the protective effect of GFG was assessed. Results: The results showed that pre-treatment with GFG reduced the levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Moreover, GFG showed anti-oxidant activities characterized by reducing hepatic MDA contents and increasing hepatic SOD and GSH levels, accompanied by inhibiting expression level of 4-HNE. Likewise, GFG decreased APAP-induced the expression of cytochrome P450 E1 (CYP2E1). Pre-treatment with GFG significantly inhibited pro-inflammatory factors tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), Bax, Bcl-2 and cyclooxygenase-2 (COX-2) levels expression of which contributed to ameliorating APAP caused hepatotoxicity. Furthermore, liver histopathological observation provided further evidence that GFG pretreatment significantly inhibited APAP-induced hepatocyte necrosis, inflammatory cell infiltration. Conclusion: The present study clearly showed that GFG exerted a protective effect against APAP-induced hepatotoxicity due to its anti-oxidant, anti-apoptotic and anti-inflammatory effects.
  Shu-quan Xin , Zi Wang , Wei-Nan Hao , Xiao-Tong Yan , Qi Xu , Ying Liu , Wei Liu , Yan-Fei Li , Xin-Dian Li and Wei Li
  Background and Objective: The roots of Codonopsis lanceolata have been used in traditional medicine for treatment of many diseases in China. Till now, there is no evidence on the liver protection effect of C. lanceolata on alcohol-induced liver injury. The purpose of this study was to investigate the hepatoprotective effect of steamed C. lanceolata (SCL) on ethanol induced liver injury in mice. Materials and Methods: Experimental mice were pretreated with different doses of SCL (100-400 mg kg1) for 2 weeks by gavage feeding. Biochemical markers and enzymatic antioxidants from serum, liver tissue were determined. Results: The results showed that the activities of ALT, AST and TG in serum, MDA level in liver tissue, decreased significantly (p<0.05) in the SCL-treated group compared with the alcohol group. On the contrary, the GSH level was increased markedly (p<0.05). Histopathological examination revealed that SCL (400 mg kg1) pre-treatment noticeably prevented alcohol-induced hepatocyte apoptosis and fatty degeneration. Moreover, LC-MS/MS analysis of SCL showed that it mainly contain Lobetyolin, Tangshenoside, Lancemasides F, Lancemasides B (Lancemasides E, Codonolaside), Lancemasides G, Lancemasides A (Codonoposide, Codonolaside) and Codonoposide. Conclusion: These results provide the evidence on possible application of SCL on acute alcohol-induced oxidative stress and liver damage in clinic.
  Jing Zheng , Wan-Hua Shen , Ting-Jia Lu , Yang Zhou , Qian Chen , Zi Wang , Ting Xiang , Yong-Chuan Zhu , Chi Zhang , Shumin Duan and Zhi-Qi Xiong
  Endocytosis of Trk (tropomyosin-related kinase) receptors is critical for neurotrophin signal transduction and biological functions. However, the mechanism governing endocytosis of TrkB (tropomyosin-related kinase B) and the specific contributions of TrkB endocytosis to downstream signaling are unknown. In this study, we report that blocking clathrin, dynamin, or AP2 in cultured neurons of the central nervous system inhibited brain-derived neurotrophic factor (BDNF)-induced activation of Akt but not ERK. Treating neurons with the clathrin inhibitor monodansylcadaverine or a peptide that blocks dynamin function specifically abrogated Akt pathway activation in response to BDNF but did not affect the response of other downstream effectors or the up-regulation of immediate early genes neuropeptide Y and activity-regulated cytoskeleton-associated protein. Similar effects were found in neurons expressing small interfering RNA to silence AP2 or a dominant negative form of dynamin that inhibits clathrin-mediated endocytosis. In PC12 cells, ERK but not Akt activation required TrkA endocytosis following stimulation with nerve growth factor, whereas the opposite was true when TrkA-expressing neurons were stimulated with nerve growth factor in the central nervous system. Thus, the specific effects of internalized Trk receptors probably depend on the presence of cell type-specific modulators of neurotrophin signaling and not on differences inherent to Trk receptors themselves. Endocytosis-dependent activation of Akt in neurons was found to be critical for BDNF-supported survival and dendrite outgrowth. Together, these results demonstrate the functional requirement of clathrin- and dynamin-dependent endocytosis in generating the full intracellular response of neurons to BDNF in the central nervous system.
 
 
 
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