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Articles by Zhiping Li
Total Records ( 4 ) for Zhiping Li
  Yan Wang and Zhiping Li
  Objectives: It was well known that the utilizations of antiepileptic drugs had been shown in many countries, such as Italy, Netherlands, Dutch and so on. However, those in China were rarely disappeared. In this study, the AEDs using pattern in clinic for children at Shanghai of China were studied. Moreover, the application of monotherapy and polytherapy of AEDs was analyzed to assess whether drug mono and polytherapy are rational or not. Methods: In this study, 8160 prescriptions of total 1,483,061 children aged 0-18 years in the Children’s Hospital of Fudan university on the diagnosis of epilepsy were retrieved from July, 2014 to October, 2015. Prescribing pattern of AEDs and the individual AEDs applied to monotherapy and polytherapy on using rate and dosage were analyzed. Besides, the utilization of valproic acid (VPA), levetiracetam (LEV) and topiramate (TPM) prescribed to different ages of children were covered. Results: Children aged from 2-11 years were the most frequency in the prescriptions with 74.07%. The VPA solution, LEV tablet, oxcarbazepine (OX) tablet and TPM were in the highest frequency used both in monotherapy and polytherapy. Meanwhile, proportion of older and newer AEDs on polytherapy arrived at 59.83 and 53.84%, which was higher than those of monotherapy with 18.67 and 39.63%. Furthermore, the dosage was increased from 9.50±0.17 to 11.49±0.34 mL in VPA group, from 4.79±0.1 to 5.61±0.19 mL in LEV group and from 59.45±2.46 to 77.34±3.06 mg in TPM with the number of medication added on polytherapy, which were significantly higher than monotherapy. Conclusion: The usage of newer AEDs in children was all-too-frequency at Shanghai of China, while polytherapy was most commonly used in Chinese children and certain different dose between monotherapy and polytherapy was found in VPA, LEV and TPM.
  Yan Wang and Zhiping Li
  Background and Objectives: CYP3A5*3 with higher frequency was found to affect the metabolisms of many drugs such as tacrolimus and maraviroc and was proved to be one of the major factors influencing the inter-individual discrepancy in different races. In the present study, the effect of CYP3A5*3 on the plasma concentration and efficacy of valproic acid (VPA) was analyzed to explore the role of CYP3A5*3 in the inter-individual discrepancy. Methodology: A total of 64 children with epilepsy who administered by VPA were recruited. Then, serum VPA concentrations were measured by direct chemiluminescence assay and the polymorphism of CYP3A5 (rs776746) was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Difference among the CYP3A5 allele on dose, concentration, adjusted concentration (AC), concentration-dose ratio and efficacy of VPA was analyzed by one-way ANOVA or t test. Results: Doses for GG carriers were significantly higher than those for AG carriers (p = 0.037). Moreover, both AC and concentration-dose ratio in patients carrying GG genotype were lower than those in AG type patients (p = 0.049, p = 0.001). However, there was no statistical difference in the frequency of CYP3A5*3 type among controlled, improved and uncontrolled-seizure groups (p = 0.9). Conclusion: The GG genotypes could decrease the AC and concentration-dose ratio of VPA which might provide a potential mechanism underlying inter-individual discrepancy of VPA, however, CYP3A5*3 did not influence the efficacy of VPA.
  Jinmiao Lu , Qin Li , Xiaoxia Li and Zhiping Li
  Background and Objective: Ceftriaxone is a frequently used antibiotic in children. This paper is to raise awareness of the challenges in managing ceftriaxone-induced hemolytic anemia and requesting more successful and useful predicting tools in its detection and prevention in pharmacogenomics field. Methodology: An adversary case report of a 5 years old boy who died from ceftriaxone-induced hemolytic anemia within 12 h in children’s hospital though all resuscitation attempt made. Results: Soon after intravenously ceftriaxone, the patient developed acute reaction to ceftriaxone presented with cold and pallor skin with shallow breath etc. Therefore, ceftriaxone infusion was stopped immediately and the patient was moved to emergency room (ER) for resuscitation from hematology outpatient clinic. Until his heart rhythm returned to normal and stabilized, he was then transferred to Pediatric Intensive Care Unit (PICU). Further, the patient developed bradycardia, reduced blood pressure, unconsciousness, under-responsiveness and oliguria. Additionally, his urine was turned from pale yellow to dark red. Urinalysis determined occult blood and trace protein existence. The hemoglobin level was 9.2 g L–1. Coomb’s test came back strong positive accompany with positive anti-C3d antibody. Hemolytic crisis was suspected. Unsuccessfully, the patient died from hemolytic shock, although all emergent resuscitation attempts were made. Conclusion: Ceftriaxone induced autoimmune hemolytic is extremely rare but could be severe as life-threatening condition stressed in pediatric. Its treatment is clinical challenging with poor outcome. Therefore, prevention is the key compared to treatment.
  Zhiping Li , Chenguang Wang , Xuanmao Jiao , Sanjay Katiyar , Mathew C. Casimiro , George C. Prendergast , Michael J. Powell and Richard G. Pestell
  Cyclin D1 is an important cell cycle regulator, but in cancer its overexpression also increases cellular migration mediated by p27KIP1 stabilization and RhoA inhibition. Recently, a common polymorphism at the exon 4-intron 4 boundary of the human cyclin D1 gene within a splice donor region was associated with an altered risk of developing cancer. Altered RNA splicing caused by this polymorphism gives rise to a variant cyclin D1 isoform termed cyclin D1b, which has the same N terminus as the canonical cyclin D1a isoform but a distinct C terminus. In this study we show that these different isoforms have unique properties with regard to the cellular migration function of cyclin D1. Although they displayed little difference in transcriptional co-repression assays on idealized reporter genes, microarray cDNA expression analysis revealed differential regulation of genes, including those that influence cellular migration. Additionally, whereas cyclin D1a stabilized p27KIP1 and inhibited RhoA-induced ROCK kinase activity, promoting cellular migration, cyclin D1b failed to stabilize p27KIP1 or inhibit ROCK kinase activity and had no effect on migration. Our findings argue that alternate splicing is an important determinant of the function of cyclin D1 in cellular migration.
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