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Articles by Zhili Xu
Total Records ( 2 ) for Zhili Xu
  Shujing Meng , Zhili Xu , Xinpeng Dai , Jianfeng Sun and Zhuo Yang
  Background and Objective: Stalk of Lentinus edodes, which often discarded in large amounts after Lentinus edodes process is a kind of material that is rich in dietary fiber. The objective of study was to obtain a suitable way to extract Soluble Dietary Fiber (SDF) from the stalks of Lentinus edodes and provide theoretical basis for further processing of it. Methodology: According to single-factor and response surface methodologies, suitable conditions for extracting SDF were determined through enzymatic hydrolysis based on extraction yield of water-SDF and one-way-analysis of variance (ANOVA) followed by Least Significant Difference test (LSD) and Duncan’s multiple range test (Duncan) at p<0.05 were used to verify significant differences in evaluated parameters. Results: The optimal conditions for the SDF extraction rate are 52°C extraction temperature, 87 U g–1 enzyme concentration, 100 mesh number and 50 min extraction duration. On this condition, the SDF extraction rate is 14.33%. Water holding capacity and swelling property of SDF from stalks of Lentinus edodes measured 10 g/g and 0.93 mL g–1, respectively. Conclusion: It is concluded that stalks of Lentinus edodes serve as good sources of SDF. Reliable and feasible optimization of SDF extraction from stalks of Lentinus edodes can be achieved through response surface method.
  Zhili Xu , Jie Tian , Jeffrey S. Smith and Andrew P. Byrnes
  Kupffer cells (KCs) rapidly remove intravenously injected adenovirus (Ad) vectors from the circulation. A better understanding of the mechanisms involved could suggest strategies to improve Ad gene delivery by suppressing or evading KC uptake. We recently showed that clearance of Ad type 5 vectors by KCs does not involve the interaction of Ad with the well-established Ad receptors, namely, integrins or the coxsackievirus and Ad receptor (J. S. Smith, Z. Xu, J. Tian, S. C. Stevenson, and A. P. Byrnes, Hum. Gene Ther. 19:547-554, 2008). In the current study, we systematically quantified the contributions of various receptors and plasma proteins to the clearance of Ad by KCs. We found that scavenger receptors are a predominant mechanism for the clearance of Ad by KCs. In addition, we found that Ad is opsonized by natural immunoglobulin M antibodies and complement and that these opsonins play a contributory role in the clearance of Ad by KCs. We also examined additional mechanisms that have been postulated to be involved in the clearance of Ad, including the binding of Ad to platelets and vitamin K-dependent coagulation factors, but we found that neither of these were required for the clearance of Ad by KCs.
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