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Articles by Zhihui Hao
Total Records ( 4 ) for Zhihui Hao
  Zhihui Hao , Yongda Zhao , Baohan Qu , Haoting Wu , Lihua Hao , Zhaopeng Ding , Fenfang Yang and Yan Li
  The objective of this study was to campare different pharmacokinetic parameters of a locally manufactured (Tulathromycin Injection, CONTINENT, China) and reference (Draxxin, Pfizer, USA) formulation of tulathromycin 2.5 mg injection after intramuscular administration of a single dose. Twelve pigs were randomly allocated to two treatment groups. Blood samples were collected by venipuncture of the jugular vein or anterior vena cava, plasma samples were analyzed by High-Performance Liquid Chromatography (HPLC) with tandem mass spectrometry detection (LC-MS/MS) using ESI. Mean puls or minus Standard Deviation (SD) of peak plasma Concentration (Cmax) Area Under the serum Concentration-time curve (AUC0-t), Area Under the serum Concentration-time curve (AUCinf), serum concentration half-life (t1/2) were 4.32±1.52 and 5.86±1.28 μg mL-1, 3.98±1.63 and 4.24±1.30 μgh mL-1, 4.04±1.67 and 4.65±2.01 μgh mL-1, 83.55±12.84 and 79.25±10.64 h for the locally manufactured (tested) and reference formulation, respectively. The 90% confidence intervals of the mean of the difference between log-transformed values for AUC0-360, AUC0-∞ and Cmax were within the bioequivalence accepted range of 80-125%. The results indicate that tulathromycin was rapidly absorbed, eliminated slowly and highly bioavailable following a single dose which make tulathromycin likely to be effective in swine.
  Zhihui Hao , Yongda Zhao , Haoting Wu , Lihua Hao , Zhaopeng Ding , Fenfang Yang and Baohan Qu
  The aim of the study was to investigated the influence of dietary inclusion of tulathromycin at 5 mg kg-1 die on haematological to provide an experiment support for the clinical use of this drug. Eighteen pigs were randomly allocated to three treatment groups. A further six pigs were left untreated as controls (group NTXL). Tulathromycin was administered twice by the oral route administrations of 5, 15, 25 mg kg-1 B.W. in three treatment groups on the 1st and the 4th day, respectively. Blood samples were taken from all animals on days 1, 17, 14 for serum chemical and hematology evaluation. Weight and temperature were measured from all animals at the same time. Comparisons of mean physical examination parameters between treatment and control groups over the 14 day study period revealed no significant differences (p>0.05). All pigs did not show any signs of discomfort after Premix. Hematology evaluation indicated that comparisons of RBC, WBC, HGB, HCT, MCV, MCH, MCHC and PLT between treatment and control groups also revealed no significant differences (p>0.05). AST, ALT, ALP, ALB, BUN were significantly higher in treated groups when compared with the control group (p<0.05) post-treatment. No significant differences as time goes on suggesting that a slight effect of injury on liver was caused by tulathromycin. The safety of tulathromycin Premix in target animal swine indicated that pigs were administered of 5-25 mg kg-1 B.W. via the oral route satisfied clinicians’ demands.
  Kefeng Xiao , Zhihui Hao , Dedong Hu and Leilei Wang
  Solution Enhanced Dispersion by Supercritical fluid (SEDS) process is utilized more and more widely for preparing nano-drug. Nozzle is the key component in SEDS process. In this study, the flow in jet-swirl nozzle for preparing nano-drug in SEDS process was analyzed by Computational Fluid Dynamics (CFD). It can be concluded from the results that the jet mixing length was found to be a strong function of the volume flow of supercritical CO2 (SC-CO2) at the inlet of the swirl chamber. When the volume flow of SC-CO2 was equal to or greater than 25 mL min-1, methylene chloride and SC-CO2 mixed completely in the nozzle. These results were coincident with the results obtained from experiments in literature. In additional, it also was indicated that the turbulent intensity at the outlet was all even in different volume flow of SC-CO2 and with the increase of volume flow of SC-CO2, the turbulent intensities at the outlet become greater and greater. These results were similar with the results obtained from experiments in literature. By these CFD analysis and comparison with literature, the flow parameters in jet-swirl nozzle were revealed and the method of CFD analysis for SEDS process was validated.
  Kefeng Xiao , Zhihui Hao and Leilei Wang
  The comparison on the performance between tangential-inlet swirl nozzle and coaxial nozzle was conducted by Computational Fluid Dynamics (CFD) simulation. The two nozzles were special for the preparation of nano-drug in Solution enhanced dispersion by supercritical fluid (SEDS) process. Turbulent intensity, velocity magnitude and volume fraction of ethanol were selected to act as the parameters to be compared. The results of CFD simulation indicate that, on the one hand, both coaxial nozzle and tangential-inlet swirl nozzle can meet the requirement of preparing nano-drug in SEDS process and have their advantages. Coaxial nozzle can prepare particles with more even size distribution than tangential-inlet swirl nozzle. And tangential-inlet swirl nozzle, with more merits, can produce higher turbulence intensity on the boundary layer which prevents the crystal nuclei precipitated from adhering on the inner wall. In additional, tangential-inlet swirl nozzle can produce higher velocity at outlet which can decrease the growth time of crystal nuclei so as to prepare superfine particles. On the other hand, both of the nozzles have their relative defects which should be improved in future study.
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