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Articles by Zhihua Ren
Total Records ( 2 ) for Zhihua Ren
  Zhicai Zuo , Hengmin Cui , Xi Peng , Junliang Deng , Jing Fang , Ya Wang and Zhihua Ren
  The objective of this study was to determine cytokine and chemokine microarray profiles in lung and Hilar Nodes (HN) from pigs infected with Actinobacillus Pleuropneumoniae (APP). Twenty pigs were randomly assigned to one of two groups: Control Group (CG) and inoculated with APP (TG). The infected-APP pigs’ lung exhibited significantly (p<0.05) greater levels of chemokines CCL2, CCL20, IL8 and slightly increase levels of chemokines CCL4, CCL5 and CXCL2 while significantly(p<0.05) decrease levels of chemokines CXCL10 and CXCL12. APP infection significantly (p<0.05 or 0.01) stimulated expression of cytokines IL-18, IL-6, TNF, GM-CSF, CASP3, CASP8 and significantly (p< 0.05 or 0.01) suppressed expression of cytokines CD40, IRF1 in lung. Cytokines in infected-APP pigs’ lung, IL-1A, IL-27, IRF3, IL-10 were slightly increased and CASP1, IRF7, IL-12B, IL-2 were slightly decreased. Relative cytokine and chemokine microarray data in HN indicated that APP infection significantly (p<0.05) stimulated expression of cytokine IL-6 and significantly (p<0.05 or 0.01) suppressed expression of cytokines CXCL12, CD40 and CASP1. In conclusion, 26 cytokine and chemokines mRNA expression levels in lung and HN obtained from infected-APP or control swines were elucidated in this study. This research provided evidence that the increased severity of lesions in the infected-APP swines was associated mainly with alterations of cytokine and chemokines microarray profiles, especialy in lung. The changes of all the cytokines in lung and HN can lead stem cells to produce granulocytes (neutrophils, eosinophils and basophils) and monocytes and also promoted neutrophil and macrophages to phagocytose bacterial and foreign antigen at the site of inflammation. Defense function of pig infection with APP was enhanced while immune function was weakened.
  Zhijun Zhong , Yongjiu Luo , Yang Yang , Chengdong Wang , Xuehan Liu , Desheng Li , Tingmei He , Wuyang Gu , Fangyuan Wang , Zhiyao Zhou , Tianliang Tang , Shengquan Ai , Gangshi Li , Xiaoxiao Zhou , Xiaoyang Xu , Bingbing Xie , Zhihua Ren , Hemin Zhang , Suizhong Cao , Liuhong Shen , Hualin Fu and Guangneng Peng
  The diet conversion period (1-1.5 years) is a special time for the giant panda. During this period, giant pandas need to adapt from a high-protein diet to highly fibrous bamboo as their main food and form a special digestive system that will digest cellulose and hemicellulose. Previous studies have shown that diet alterations affect intestinal microbiota composition and host resistance. Intestinal microbiotas play a key role in the giant panda’s ability to digest highly fibrous bamboo. In this study, researchers constructed a 16S rRNA gene library from three giant pandas’ feces to investigate the diversity and structure of its bacterial population during the diet conversion period. Results showed that the diversity of intestinal bacteria during the earlier and later diet conversion periods is higher than at the middle diet conversion period. Intestinal floras within the giant panda gut were affiliated with the phyla Firmicutes, Proteobacteria, Bacteroidetes, Fusobacteria and uncultured bacterium. The phyla Firmicutes and Proteobacteria were the predominant bacteria throughout diet conversion although their proportions fluctuated. Within the phylum Firmicutes, the majority of bacteria were Clostridium, Streptococcus and Lactobacillus but while in the phylum Proteobacteria, the predominant bacteria were Escherichia and Acetobacter. This is the first study to monitor bacterial diversity in feces from captive giant pandas during the diet conversion period.
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