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Articles by ZhiZhong Jing
Total Records ( 2 ) for ZhiZhong Jing
  Xuepeng Cai , Gailing Yuan , Yadong Zheng , Xuenong Luo , Shaohua Zhang , Juntao Ding , Zhizhong Jing and Chengping Lu
  Cysticercosis caused by Taenia solium metacestodes is a worldwide public health problem. Important progress in the development of effective and practical vaccines against this disease has been made. In this study, the promising T. solium oncospheral vaccine candidate named TSOL18 antigen was produced in a 5-liter fermentor. During the process of fermentation, the pH of the culture was always kept below 5.0, and in order to prevent foaming, an antifoam agent was added. In addition, the oxygen content of the culture was constantly kept at >50% in our experiment. A high level of the glycosylated protein (2.5 g/liter) was obtained, and the protein was easily purified by gel chromatography. Vaccination trials showed that the recombinant TSOL18 antigen induced 94 and 100% reductions in metacestode burdens in vaccinated pigs, obviously higher than the 89% reduction in pigs immunized with cysticercus crude extracts in trial 1. These are very promising results in the development of an efficient tool to control cysticercosis in Asia.
  GuoHua Chen , HuaiJie Jia , YaDong Zhen , Shuang Zeng , YongXiang Fang , XiaoBing He , ZhiZhong Jing and XuePeng Cai
  The yak (Bos grunniens) is an important grazing livestock in Western of China. In this study, the full length of yIFN-a1 gene was cloned then the recombinant yIFN-a1 was expressed in yeast expression system. In vitro bioactivity of IFN-α1 was determined by inhabition infection BHK cell against Vesicular Stomatitis Virus (VSV). The results showed that cDNA contains an Open Reading Frame (ORF) of 570 base pairs encoding a protein of 189 amino acid (aa) precursor with a signal peptide of 23 aa. The homology of the yIFN-a1 was up to 65.3~94.4% with other species at the amino acid levels. The recombinant yIFN-a1 was recognized in Western blot by mAb against human IFN-α1. The activity unit of the purified recombinant yIFN- a1 protein was 1.16×105 IU mg-1 by against Vesicular Stomatitis Virus (VSV) antiviral assay in vitro. This made a basis for the development of anti-virus medicine of yak in the future.
 
 
 
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