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Articles by Zakia Sultana Sathi
Total Records ( 3 ) for Zakia Sultana Sathi
  M. Zakir Sultan , Naznin Ara Khatune , Zakia Sultana Sathi , Md. Shah Alam Bhuiyan , M. Golam Sadik , M. Akteruzzaman Choudury , M. A. Gafur and Md. Aziz Abdur Rahman
  The ethyl acetate extract of yeast extract-glucose broth medium of an Actinomycetes strain, Streptomyces yielded a reddish yellow antibiotic metabolite by chromatographic technique and was identified as 2 N-butanamide 3-methyl 4-methoxy 5-β-L-arabinosyl propanophenone (MZ-4) on the basis of spectral data. The compound exhibited significant antibacterial activity against five gram positive and nine gram negative bacteria when compared with standard Kanamycin antibiotic. The zone of inhibition were observed between 17 to 20 mm. The minimum inhibitory concentration (MIC) of the compound was determined against four gram positive and gram negative bacteria and the values were found between 32 and 64 μg ml-1.
  Ranjan Kumar Barman , Zakia Sultana Sathi , M. Anwar Habib , M. Aktar Uzzaman Chowdhury , M. Helal Uddin Biswas , M.A. Gafur and M. Aziz Abdur Rahman
  The subacute toxicity studies of 8-propionato-2-β (D+) glucosyl-9, 10-pyranopyridine (R-1), isolated from the Streptomyces species was carried out in Long Evan`s rats. The compound was administered at a dose of 300 μg/rat/day for 14 consecutive days. The gross general observations such as changes of body weight, hematological profiles, biochemical parameters of blood and the histopathology of the liver, kidney, heart and lungs were investigated both in control and experimental rats. The body weights of the rats were slightly increased. The change of hematological and biochemical parameters were statistically nonsignificant. No abnormalities were detected in the histopathology of the liver, kidneys, heart and lungs in the experimental group of rats as compared with control group of rats.
  M. Zakir Sultan , Zakia Sultana Sathi , M. Helal U. Biswas , M. Akteruzzaman Choudury , M. Aziz Abdur Rahman and M.A. Gafur
  The ethyl acetate extract of yeast extract-glucose broth medium of an Actinomycete strain, Streptomyces yielded three active metabolites C-1, C-2 and C-3, among which C-3 was identified as 2-N-butanamide-3-methyl-4-methoxy-5-β-L-arabinosyl-propanophenone on the basis of spectral data. The cytotoxic activity of the crude ethyl acetate extract and compound 1, 2 and 3 were determined by brine shrimp lethality bioassay. The compounds showed lower LC50 values indicating that these compounds were significantly cytotoxic. The LC50 of the crude ethyl acetate extract, C-1, C-2, C-3 and standard ampicillin trihydrate were 6.69, 12.30, 4.67, 6.62 and 10.28 μg ml-1 respectively.
 
 
 
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