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Articles by Z.S.C. Okoye
Total Records ( 2 ) for Z.S.C. Okoye
  H.C.C. Maduka , Z.S.C. Okoye and M. Mahmood
  The amino acid profile and anionic composition of three aqueous preparations of Sacoglottis gabonensis stem bark were determined. Curde extract of Sacoglottis gabonensis stem bark prepared in 4% ethanol (1:10w/v), the deffated fraction of the ethanol crude extract and methanol extract (1:10w/v) were analyzed. The anionic composition analysis showed that in ethanolic extract, Cl- was present in highest amount followed by NO3- then F- and lastly SO42- being 27.7 ± 1.25, 6.82 ± 0.11, 5.10 ± 0.30 and 3.08 ± 0.11 ppm respectively. The deffated ethanol extract contained Cl- in highest quantity followed by SO42- and then NO3- and finally F-being 24.8 ± 0.98, 12.34 ± 0.15, 9.14 ± 0.38 and 5.10 ± 0.30 ppm respectively. The methanolic extract contained Cl-, SO42-, NO3- and F- to the extent of 30.3 ± 1.08, 6.77 ± 0.11, 4.77 ± 0.20 and 4.12 ± 0.18 ppm respectively of the anions. Results showed that while the ethanol crude extract contained eleven amino acids including seven essential amino acids (1 ys, Leu, Ile, Tyr, Thr, His and Val), the defatted extract and methanolic extract contained 13 and 17 amino acids respectively including all the nine essential amino acids. Both the defatted portion and methanolic extract contained Cys thus suggesting a role in detoxification of autooxidizable drugs. The bark extract can serve as alternative source of essential amino acids and hence relevant in nutrition. Toxic species like CN, Cd and Hg that could inhibit drug metabolizing enzymes were absent. Methanol is the best extractor while defatting unmasked Phe and Met which were not detected in the crude extract.
  H.C.C. Maduka , H. M. Uhwache and Z.S.C. Okoye
  The study of the protective effects of Sacoglottis gabonensis stem bark extract on the peroxidative deterioration of some common stored vegetable oils in Maiduguri over a period of time was carried out in comparison with vitamins C and E. Lipid peroxidation was monitored as lipid hydroperoxide carbonyls and lipid aldehydes concentrations on a time course basis over a period of 35 days in the vegetable oil test free and their respective antioxidant treated test samples. The treatment with the bark extract reduced the rate of formation of malondialdehyde and malonaldehyde at a rate that compared favourably with the inhibitions obtained with the antioxidants, vitamins C and E. The mechanism of inhibition of the observed anti-oxidant action of the bark extract appeared to be by inhibition of propagation of lipid peroxidation. Results obtained seemed to have confirmed earlier reports that the bark extract could find ready application as a nutritional antioxidant additive.
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