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Articles by Z.M. Noor
Total Records ( 2 ) for Z.M. Noor
  R. Ahmad , H.M. Hashim , Z.M. Noor , N.H. Ismail , F. Salim , N.H. Lajis and K. Shaari
  The aim of the study was to evaluate the antioxidant and antidiabetic potential of five Malaysian Uncaria species namely U. lucida, U. acida, U. cordata, U. callophylla and U. longiflora var. pteropoda, find any correlation between these two activities and relate them to their phytochemical content. Measurement of antioxidant activities employed ferric thiocyanate (FTC), thiobarbituric (TBA) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays while evaluation of total phenolic contents employed Folin Ciocalteau methods. Antidiabetic potential was evaluated by α-glucosidase inhibitory assays. All tested extracts exhibited very strong antioxidant potential in the FTC and TBA assays. U. longiflora v.p. (stems and leaves) and U. calophylla (stems) exhibited strong DPPH free radical scavenging activity with IC50 values of 8-20 μg mL-1 compared to 8 μg mL-1 for vitamin C and 7 μg mL-1 BHT. In the α-glucosidase inhibitory assay, the stem extracts of the two plants showed strong α-glucosidase inhibition (>99%). The anti-diabetic activity exhibited by the two plants correlated well with its radical scavenging activities and its phytochemical content. This study has found Malaysian Uncaria to be potentially important sources of antioxidants and anti-diabetic agents, which may be used in prevention and control of type II diabetes.
  N.A. Wahab , Z.M. Noor and M.F.F. Abdullah
  An E. coli yeast shuttle vector for the anchoring of heterologous protein to the yeast host’s cell wall was constructed. The vector PYDSM01 includes a DNA sequence constructed from the signal sequence from the yeast sucrose isomerase gene, a multiple cloning site and a DNA fragment encoding the carboxyl-terminal of the yeast cell wall protein 2 (CWP2). This construct was then inserted into the HindIII site on pGAD424, replacing the GAL4 fusion tag and the original MCS sequence. DNA sequencing confirmed the correct insertion of both signal and anchor proteins in the vector. To test for proper expression and functional anchoring to the cell wall, the coding sequence for a bacterial alpha-amylase enzyme was cloned into the vector and transformed into a yeast host. A total of 22 yeast transformant were recovered which were able to degrade starch, indicating successful expression and function of the bacterial alpha-amylase gene. Enzyme assay of the washed cell pellet and supernatant fractions indicate that the both activity and anchoring efficiency are variable.
 
 
 
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