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Articles by Z.M. Hassan
Total Records ( 2 ) for Z.M. Hassan
  A.A. Imanifooladi , M. Sattari , Sh. Najar Peerayeh , Z.M. Hassan and S.R. Hossainidoust
  Staphylococcus aureus is a major human pathogen that produces a wide array of toxins, thus causing various type of disease symptoms. Staphyloceccal enterotoxins (SES), a family of 9 major serological types of heat-stable enterotoxins, are a main cause of gastroenteritis and skin infection. In this study to determine the extent of enterotoxin-producing S. aureus in skin infections of hospitalized patients, their samples were screened and the results showed that 42% of totally 200 patients studied in this research carried S. aureus and 45% of these S. aureus produced Staphylococcal enterotoxins. Twenty percent produced enterotoxin A, 25% produced enterotoxin B and 4.7% produced both enterotoxin A and B. The results demonstrated a high level of enterotoxigenic and multi drug resistance S. aureus in skin infections of hospitalized patients.
  K. Mansouri , M. Mirshahi , A. Pourfathollah , Z.M. Hassan and R. Taheripak
  Angiogenesis is a complex process during which of new blood vessels are produced from the pre-existing blood vessels. Formation and growth of new vessels play an important role in the physiologic process (embryonic growth, tissue repair) and pathologic process (tumor growth, inflammation) for surviving of the tissues. In fact, the development of tumors is depended upon new vessel formation through which the tumor is provided with nutrient and oxygen. In this research, the role of plasminogen conformation with MC2B8 mAb (an antibody directed against C-terminal part of plasminogen) in clot lysis and angiogenesis is observed. In experimental model of angiogenesis, beads, covered with endothelial cells of bone marrow capillaries, are the source of endothelial cells. It coated in three-dimensional structure to be provided through fibrin gel. Different titers of monoclonal antibody (30-480 μg mL-1) MC2B8 were added in fibrin gel. 3-5 days after culturing of endothelial cells, growth and migration was seen as the result of capillary formation MC2B8 mAb delayed clot lysis and inhibited angiogenesis at the concentration of 240 μg mL-1. Present findings suggest that these effects on capillary tube formation and clot lysis caused blockage or conformational changes in plasminogen epitopes involved in angiogenesis and fibrinolysis.
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