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Articles by Z. Zhang
Total Records ( 8 ) for Z. Zhang
  M Wang , W Zhang , L Yuan , G Fu , Q Wei and Z. Zhang
 

A recent genome-wide association study identified two common variants that confer susceptibility to bladder cancer. We hypothesized that these variants are associated with risk of bladder cancer in Chinese populations. We genotyped rs9642880 G>T on 8q24 and rs710521 A>G on 3q28 in a two-stage case–control study of bladder cancer to evaluate the association and further examined the expression of MYC. We found that the rs9642880 G>T, but not the rs710521 A>G polymorphism, was associated with an increased risk of bladder cancer. Compared with the rs9642880 GG genotype, the GT/TT genotypes were associated with an odds ratio of 1.65 (95% confidence interval = 1.25–2.17), and this risk was more pronounced in young men and for low-risk tumors. Additional experiments revealed that the rs9642880 GT/TT genotypes were associated with enhanced levels of both MYC mRNA and protein in bladder tissues. Our findings suggested that the rs9642880 G>T polymorphism on 8q24 was independently associated with the risk of bladder cancer in Chinese populations.

  S Wang , J Tang , M Wang , L Yuan and Z. Zhang
 

Recently, two genome-wide association studies identified a significant association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and risk of diffuse-type of gastric cancer in Asians and bladder cancer in Caucasians, respectively. PSCA has been reported highly expressed in bladder cancer and been considered as a useful marker for diagnosis and progression of bladder cancer. To determine whether rs2294008 polymorphism is associated with risk of bladder cancer in Chinese populations, we conducted a hospital-based case–control study of 581 cases and 580 controls. Sixteen normal bladder tissues adjacent to tumors were used to evaluate the functionality of this polymorphism. We genotyped the rs2294008 polymorphism and assessed its association with risk of bladder cancer and messenger RNA (mRNA) expression in normal bladder tissues. A significant increased risk of bladder cancer was found for rs2294008 CT/TT genotypes (adjusted odds ratio, 1.38; 95% confidence interval, 1.09–1.75) compared with the CC genotype. Furthermore, analysis of PSCA mRNA expression identified a clear correlation of rs2294008 with expression levels of PSCA mRNA. These results indicated that the rs2294008 polymorphism of PSCA gene may play a role in bladder cancer carcinogenesis and it could be served as a biomarker for genetic susceptibility to bladder cancer in Chinese populations.

  M. Y. Kan , D. Z. Zhou , D. Zhang , Z. Zhang , Z. Chen , Y. F. Yang , X. Z. Guo , H. Xu , L. He and Y. Liu
  Aims  To investigate the two variants (rs1387153 and rs10830963) near/in the melatonin receptor 1B gene (MTNR1B) and to determine their association with Type 2 diabetes, as well as with the regulation of fasting plasma glucose (FPG) in Han Chinese subjects.

Methods  The two variants were genotyped in 1912 unrelated Type 2 diabetic patients and 2041 healthy individuals. Association with Type 2 diabetes was calculated by logistic regression with adjustments for sex, age and body mass index. The possible connection between the risk alleles and FPG was analysed by multiple linear regression.

Results  The two polymorphisms were associated with FPG levels in the healthy individuals (P = 0.003 and P = 0.002, respectively), and the G allele of rs10830963 was also associated with an increased risk of Type 2 diabetes in our patient sample (odds ratio, 1.12; 95% confidence interval, 1.02-1.23; P = 0.024). Moreover, the linkage disequilibrium degree of two single nucleotide polymorphisms was high (r2 = 0.66), which is similar to that of Europeans.

Conclusions  The common variant in MTNR1B confers the risk of Type 2 diabetes and modulates FPG in both the Han Chinese and European populations.

  J Han , Q Li , L McCullough , C Kettelkamp , T Formosa and Z. Zhang
 

FACT plays important roles in both gene transcription and DNA replication. However, how this protein complex is targeted to these two distinct cellular processes remains largely unknown. Here we show that ubiquitylation of the Spt16 subunit of FACT by Rtt101, the cullin subunit of an E3 ubiquitin ligase in Saccharomyces cerevisiae, links FACT to DNA replication. We find Rtt101 interacts with and ubiquitylates Spt16 in vitro and in vivo. Deletion of RTT101 leads to reduced association of both FACT and the replicative helicase MCM with replication origins. Loss of Rtt101 also reduces binding of FACT to MCM, but not the association of FACT with Leo1 and Spt5, two proteins involved in transcription. Origin function is compromised in cells lacking Rtt101 or with an Spt16 mutation. These findings identify Spt16 as an Rtt101 substrate, and suggest that Spt16 ubiquitylation is important for FACT to function during DNA replication.

  H Wu and Z. Zhang
 

We utilize the recovered gradient by the polynomial-preserving recovery to enhance the eigenvalue approximation of the Laplace operator under adaptive meshes. Superconvergence rate is established and numerical tests on benchmark problems support our theoretical findings.

  Z. Zhang , S. Li and J. Zhou
  Estimate request service demand is vital for resource management and capacity planning in large web servicing system. Most existing works assume the service demand is load-independent. This study showed that it is not the case for modern processors with Dynamic Frequency Scaling (DFS) and Simultaneous Multi-Threading (SMT) capabilities. Through experiments in a Xeon processor under Linux, this study showed that the CPU demand can be modeled as a polynomial function of CPU utilization with degree 2 or 3. This study proposed a quadratic programming based optimization method to infer the polynomial coefficients from readily available CPU utilization and response time data. Comparing with widely used regression method, proposed optimization method can reduce the error by more than half in most cases. Proposed method is also more accurate than the existing load-dependent estimation method, particularly in workload of requests with different sizes.
  Z. Zhang , C.Y. Zhang , J.P. Guo , L.X. Zhu , X.Y. Luo , R. Wang and Y.H. Liu
  The systemic bioavailability and lung tissue distribution of valnemulin were investigated in swine. About 65 pigs received 10 mg kg-1 body weight of valnemulin by either intravenous (i.v.) or oral (p.o.) route in two studies: study A (10 pigs, i.v. or p.o.) and study B (55 pigs, p.o.). The plasma and lung tissue concentration of the drug were determined by a validated HPLC-MS/MS method. Plasma concentration-time data after i.v. administration (10 mg kg-1 b.w.) were best described by a two-compartment open model. The pharmacokinetic parameters were elimination rate (ke) 0.95±0.17 h-1, the maximum concentrations 4.63±0.66 μg mL-1, area under the plasma concentration-time curve (AUCinf) 5.30±0.37 (h*μg) mL-1. On the other hand, A one-compartment model with a 1st order absorption rate was best fitted to the plasma concentration-time curve of valnemulin after oral administration (10 mg kg-1 b.w.) and the absorption rate (ka) was 0.34±0.03 h-1, the elimination rate (ke) was 1.05±0.19 h-1, the maximum concentration was 0.59±0.08 μg mL-1 at 1.98±0.21 h (tmax), the mean p.o. bioavailability (F) was 57.43%. Following p.o. administration, a mean valnemulin concentration of 0.14 μg g-1 was detected in lung tissue at 36 h postdosing. The lung AUCinf (410.16 h*μg g-1) was 77.39 times higher than the corresponding plasma AUCinf (5.30 h*μg g-1). The apparent elimination half-time for valnemulin in lung was 3.57 h. The advisable bioavailability and extensive distribution to lung tissue following a single dose of valnemulin may be desirable pharmacokinetic attributes for an antimicrobial drug used for the treatment and prevention of respiratory disease in swine.
  H Chu , M Wang , D Gu , D Wu , Z Zhang , J Tang and Z. Zhang
 

Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species and plays an important role in the aetiology of cancer. The MPO –463G>A polymorphism influences MPO transcription and has been implicated in cancer risk. However, results from published studies on the association between the MPO –463G>A polymorphism and risk of cancer are conflicting. To derive a more precise estimation of association between the MPO –463G>A polymorphism and risk of cancer, we performed a meta-analysis based on 43 case–control studies, including a total of 14 171 cancer cases and 17 319 controls. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Overall, individuals with the –463A allele had a 0.93-fold lower cancer risk in a dominant model (OR = 0.93, 95% CI = 0.87–1.00). In the stratified analyses, we observed a similar association in European populations (heterozygote comparison: OR = 0.90, 95% CI = 0.82–0.99) and hospital-based studies (dominant model: OR = 0.88, 95% CI = 0.79–0.99). When stratified by cancer type, however, no significant association was found. The results suggested that the MPO –463A allele does not contribute to the development of cancer. Additional well-designed large studies are required to validate these findings in different populations.

 
 
 
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