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Articles by Z. Qin
Total Records ( 3 ) for Z. Qin
  L Zhang , R Sheng and Z. Qin
 

It has long been believed that the lysosome is an important digestive organelle. There is increasing evidence that the lysosome is also involved in pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Abnormal protein degradation and deposition induced by lysosomal dysfunction may be the primary contributor to age-related neurodegeneration. In this review, the possible relationship between lysosome and various neurodegenerative diseases is described.

  Z Lu , P Xie and Z. Qin
 

The standard gene disruption and replacement to delete the actinorhodin biosynthetic gene cluster (Act) in Streptomyces coelicolor was inefficient, and the polymerase chain reaction-targeting of the cosmid could efficiently delete the Act, but still was a time-consuming procedure for markerless gene replacement. By using optimal Streptomyces codons, we synthesized a sceS gene encoding identical amino acid sequence as the chromosome rare-cutting meganuclease I-sce I of the Saccharomyces cerevisiae mitochondria. Expression of sceS gene in S. coelicolor resulted in promotion of homologous recombination and subsequently, successful achieved markerless deletion of the Act. The sceS system may be useful for the sequential markerless deletions of chromosomal segments in Streptomyces.

  C. Chang , L. Gao , H. Kou , X. Liu , Z. Qin and G. Xu
  An integrity batch report protocol based on the waiting stack is proposed, which aims at solving the bottleneck problem of the Trusted Platform Module (TPM) signature of integrity report. In the protocol, integrity attestation requests are placed sequentially in a waiting stack with constant head part and varying length. The TPM processes the integrity batch report one after another and thus the flexibility problem of trusted gateway can be solved efficiently. This study also proposes a data compressing method based on the Merkle tree to reduce the communication complexity in processing integrity batch report. The length of fresh number connection string transferred to the challenger can be compressed from mx20 bytes to log2mx20 bytes. The laboratory result indicates that the responding capacity of gateway adopting integrity batch report protocol is prior to adopting TCG integrity report protocol and the processing capacity of gateway can be improved from 1~3.3 to 32~256 times per second.
 
 
 
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