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Articles by Z. Adam
Total Records ( 2 ) for Z. Adam
  Z. Adam , M. Hamid , A. Ismail and S. Khamis
  The present study was designed to evaluate the potential of five extract and three fractions of Ficus deltoidea to enhance basal and insulin-stimulated glucose uptake into Chang liver cell line. The results showed that all Ficus deltoidea extracts and fractions except petroleum ether extract have the ability to enhance either basal or insulin-stimulated glucose uptake into liver cell line. Ethanolic and methanolic extracts as well as acidified chloroform and bacified chloroform fractions possess insulin-mimetic activity. Of all extracts and fractions, ethanolic extract possess the highest insulin-mimetic activity. Methanolic extract and n-butanolic fraction possess insulin-sensitizing activity, with the highest activity shown by methanolic extract. There is no synergistic effect between Ficus deltoidea extracts or fractions with 100 nM insulin. It can be suggested that antidiabetic action of Ficus deltoidea is partly associated with glucose disposal into liver cells.
  Z. Adam , S. Khamis , A. Ismail and M. Hamid
  The present study was undertaken to evaluate the potential of Ficus deltoidea to inhibit the enzyme, α-glucosidase in the small intestine, as this is known to be an antidiabetic mechanism. The results of the in vitro study had shown that hot aqueous, ethanolic and methanolic extracts of Ficus deltoidea inhibit rat intestine α-glucosidase activity significantly, in a concentration dependent manner. The IC50 values of these extracts are 4.15, 2.06 and 1.72 mg mLG1, respectively. From a study of the enzyme kinetics, all extracts exhibited a mixed-type inhibition mechanism against the activity of α-glucosidase. In an animal study, all extracts, when used at a dose of 1000 mg kgG1 b.wt., reduce postprandial hyperglycemia following sucrose administration. This was true in normal and in diabetic rats, as shown by the significant attenuation of the value of AUCGlucose compared to the control group. The methanolic extract is the most potent inhibitor of α-glucosidase, followed by the ethanolic and hot aqueous extracts. We suggest that the inhibition of α-glucosidase in the small intestine in part mediates the antidiabetic property of Ficus deltoidea.
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