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Articles by Z Dai
Total Records ( 2 ) for Z Dai
  Q Liu , Z Dai , Z Liu , X Liu , C Tang , Z Wang , G Yi , L Liu , Z Jiang , Y Yang and Z. Yuan
 

It has been reported that oxidized low-density lipoprotein (Ox-LDL) can increase the expression of adipophilin. However, the detailed mechanisms are not fully understood. The aim of this study was to investigate the mechanism of Ox-LDL on adipophilin expression and the intracellular lipid droplet accumulation. A mouse macrophage-like cell line, RAW264.7, was used throughout, and it was found that Ox-LDL induced adipophilin expression in a dose-dependent manner. Moreover, Ox-LDL induced peroxisome proliferator-activated receptor- (PPAR) expression and PPAR-specific inhibitor T0070907 abrogated Ox-LDL-induced adipophilin expression, but specific agonist GW1929 not. Furthermore, Ox-LDL induced phosphorylation of ERK1/2, and ERK1/2-specific inhibition by PD98059 suppressed the Ox-LDL-induced PPAR and adipophilin expression. The results showed that ERK1/2 or PPAR-specific inhibition decreased the amounts of intracellular lipid droplets. Meanwhile, the PPAR-specific agonist increased intracellular lipid droplets. These results suggested that Ox-LDL-induced increase in adipophilin level via ERK1/2 activation is one of the mechanisms of inducing greater amounts of intracellular lipid droplets in RAW264.7 cells, which indicated that adipophilin is involved in atherosclerotic progression.

  P. W Grutter , E. G McFarland , B. A Zikria , Z Dai and S. A. Petersen
 

Although suture anchor complications after arthroscopic shoulder surgery are uncommon, they can be devastating, such as articular cartilage or bone loss secondary to a dislodged or prominent suture anchor. Proper insertion of the anchor is the most important factor in the prevention of this complication, but if a complication occurs, prompt recognition and treatment are important to prevent damage to the shoulder. The goals were to (1) discuss strategies for preventing or dealing with dislodged or prominent suture anchors and (2) introduce techniques for removal of these implants.

 
 
 
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