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Articles by Yujuan Li
Total Records ( 2 ) for Yujuan Li
  Imran Suheryani , Yujuan Li , Rongji Dai , Xiujie Liu , Shoaib Anwer , Song Juan and Yulin Deng
  Background and Objective: Daibaijie (DBJ) is Chinese name of Dregea sinensis Hemsl. Traditionally it is used for treatment of various diseases. The objective of study was to determine the gastroprotective effect of DBJ against aspirin-induced gastric ulcers. Methodology: In this research 60 Sprague Dawley (SD) rats were divided into 6 groups. Water was provided to normal and negative groups, omeprazole (20 mg kg–1) to positive group and DBJ extract (1, 2 and 3 g kg–1) to low, middle and high dose groups, respectively as pre-treatment. After 1 h of pre-treatment, aspirin (250 mg kg–1) were administered to all groups except normal group. Above scheduled treatments were provided continuously for 2 weeks. After 2 weeks, rats were sacrificed. The pH plus acidity, Gastric Wall Mucus (GWM), ulcer index, histological assessment, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), myeloperoxidase (MPO), prostaglandin E2 (PGE2) and protein concentration were examined. Moreover, all the data were statistically analyzed by one way ANOVA, followed by student’s t-test to compare different groups. Results: The DBJ showed a dose-dependent (60.11-84.34%) protection, while omeprazole showed (82.74%) protection. In addition, DBJ also considerably increased (p<0.01) the pH and reduced the acidity of gastric contents. Gastric levels of antioxidant enzymes SOD, CAT, GSH-Px were markedly enhanced while MDA level and MPO activity significantly reduced (p<0.001) by DBJ. Furthermore, DBJ also increased the PGE2 level and mucus production. Conclusion: It is concluded from results, that DBJ extract has great potential to prevent stomach ulcers. The gastroprotective effect might be associated to increase in PGE2 to produce mucus and inhibition of neutrophil infiltration due to decrease in MPO activity.
  Imran Suheryani , Yujuan Li , Bo Chen , Panpan Li , Xiujie Liu , Ibtessam Tahir Ansari , Omer Saeed , Rongji Dai and Yulin Deng
  Background and Objective: Dragon’s blood (DB) is a red colored resin, extracted from Dracaena cochinchinensis (Lour.). It has terrific medicinal importance due to presence of many phenolic compounds. This study was designed to explore gastroprotective properties of DB in aspirin-induced gastric ulcers. Materials and Methods: In this study 48 Sprague Dawley (SD) rats were divided into six groups. Normal and negative groups received water, while the positive group received Omeprazole (20 mg kg–1). Remaining low, middle and high dose groups received DB (400, 800 and 1200 mg kg–1), respectively as pre-treatment. Exactly after 1 h of pre-treatment, aspirin (250 mg kg–1) were administered orally to all the groups except normal group. All drugs were administered continuously for 14 days. On 15th day, rats were sacrificed and their stomachs were collected. pH, acidity of gastric content, ulcer index, Gastric wall mucus (GWM) and other biochemical parameters like Prostaglandin E2 (PGE2), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) Malondialdehyde (MDA) and protein concentration were evaluated. Results: The DB shown a dose-related (63.98-85.18%) protection while Omeprazole showed (81.37%) protection. The DB also increased the pH and decreased the acidity of gastric contents. Gastric levels of SOD, CAT, GSH-Px were significantly (p<0.001) increased while MDA level was decreased. Furthermore, DB also enhanced the PGE2 level and mucus production. Conclusion: From the results of study, it was concluded that DB had sufficient potential to halt gastric ulcers by increasing antioxidant status and PGE2 level to produce mucus.
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