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Articles by Yuan Chen
Total Records ( 4 ) for Yuan Chen
  Xiang Gu , Yuan Chen and Bei Yang
  Take Public rental housing as key point of house guarantee system and main route to solve urban low-income family’s housing difficulties, this study has deeply analyzed on the actual situation, permanent resident population and other factors, also has borrowed management pattern drafted under advanced system; it has proposed public rental housing construction, administrative organization and operation pattern, also some problems existed in public rental housing pattern and directions needed to be improved. In the long term, it is necessary to strip public rental housing from low-cost housing system as an independent house guarantee.
  Shiyan Cao , Shining Cao , Aiwei Chen , Lanlan Yang and Yuan Chen
  Background and Objective: Anti-histamine and anti-inflammatory agents are used in treatment of allergic conjunctivitis. The objective of the study was to compare efficacy and safety of emedastine with olopatadine in Chinese allergic conjunctivitis patients. Materials and Methods: Total, 2,745 allergic conjunctivitis affected eyes were subjected to simple randomization. Patients received normal saline (VG group; n = 915), 0.2% olopatadine (OG group; n = 915) or emedastine (EG group; n = 915) in affected eyes. Interventions run for 15 days. The signs, symptoms and treatment-emergent adverse-effects were evaluated. Results: Olopatadine and emedastine were effective and safe in allergic conjunctivitis. In the morning, patients had the same satisfaction for the relief of symptoms for olopatadine and emedastine (4.32±0.25 vs. 4.29±0.38, p = 0.051). In the evening, patients had a higher satisfaction for the relief of symptoms for emedastine treatment than olopatadine treatment (4.12±0.11 vs. 2.14±0.11, p<0.0001). About 35% patients from OG group and 60% patients from the EG group have preferred their next prescription with the same treatment. Olopatadine was effective in all types of allergic conjunctivitis and emedastine was effective in seasonal and perennial allergic conjunctivitis only. For OG group, pharyngitis and for EG group, increased heart rates were reported as adverse effects. Conclusion: Olopatadine recommended in all types of conjunctivitis and emedastine recommended in seasonal and perennial allergic conjunctivitis only.
  Bingqi Duan , Yi Huang and Yuan Chen
  Background and Objective: Clinical application of anesthetics in neonatal or children causes neuronal degeneration. Present study evaluates the neuroprotective effect of barbaloin against anesthetic induced neuronal injured rats and also postulates the possible mechanism of its action. Materials and Methods: Animals on P7 were exposed for 6 h with 30% of oxygen that contain 0.75% of isoflurane and rats were treated with barbaloin 10 and 20 mg kg1, p.o. for the duration of 21 days. Cognitive function was evaluated by using morris water maze (MWM) and level of mediators of inflammation and oxidative stress were estimated in the brain tissue by using enzyme-linked immunosorbent assay (ELISA). Moreover western blot assay was performed for the determination of expression of proteins in the neuronal tissues and apoptosis of neuronal cells were observed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and Fluro Jade B staining. Results: Data of report suggest that barbaloin promotes the cognitive function by MWM and apoptosis of neuronal cells was also found to be reduced in barbaloin treated group than isoflurane (INF) group. There was decrease in the mediators of inflammation and oxidative stress in barbaloin treated group compared to INF group. Moreover western blot assay data reveals that barbaloin ameliorates the altered expression of JNK, ERK-1/2, Bcl-2, PI3K, Akt, BDNF and TrKB proteins in the brain tissues of anesthetic induced neuronal injured rats. Conclusion: Data of the report reveals the protective effect of barbaloin against isoflurane induced neuronal injured rats by regulating BDNF/Bcl-2/PI3K signaling pathway.
  Joseph-Anthony T. Tan , Yujie Sun , Jing Song , Yuan Chen , Theodore G. Krontiris and Linda K. Durrin
  SATB1 (special AT-rich sequence-binding protein-1) provides a key link between DNA loop organization, chromatin modification/remodeling, and association of transcription factors at matrix attachment regions (MARs). To investigate the role of SATB1 in cellular events, we performed a yeast two-hybrid screen that identified SUMO-1, Ubc9, and protein inhibitor of activated STAT (PIAS) family members as SATB1 interaction partners. These proteins, working in concert, enhanced SUMO conjugation to lysine-744 of SATB1. Overexpression of SUMO or PIAS in Jurkat cells, which express high levels of endogenous SATB1, exhibited enhanced caspase cleavage of this MAR-associating protein. Sumoylation-deficient SATB1 (SATB1(K744R)) failed to display the characteristic caspase cleavage pattern; however, fusion of SUMO in-frame to SATB1(K744R) restored cleavage. A SUMO-independent interaction of inactive caspase-6 and SATB1 was noted. A subset of total cellular SATB1 localized into promyelocytic leukemia nuclear bodies where enhanced SATB1 cleavage was detected subsequent to caspase activation. These results reveal a novel sumoylation-directed caspase cleavage of this key regulatory molecule. The role of regulated proteolysis of SATB1 may be to control transcription in immune cells during normal cell functions or to assist in efficient and rapid clearance of nonfunctional or potentially damaging immune cells.
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