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Articles by Yu Li
Total Records ( 5 ) for Yu Li
  Xin Wu , Fang Liu , Hui Cai , Lin Huang , Yu Li , Zhijiang Mo and Jingwei Lin
  School Refusal (SR) is a serious problem that will interfere with daily life and future of children and adolescents. To date, two ways including psychotherapy and medication are taken into consideration to treat SR. It has been reported that Cognitive Behavior Therapy (CBT) might be effective for SR. SR frequently combines with depression and anxiety and we therefore assume that fluoxetine combined with CBT may increase the efficiency of CBT for SR. Our study investigated the efficacy of CBT combined fluoxetine treatment and CBT alone for School Refusal (SR). A total of 75 patients with SR were randomized into two groups: CBT group (n = 36) and CBT plus Fluoxetine group (n = 39). Treatment was done for 12 weeks. The Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale, Clinical Global Impression-Severity scale (CGI-S) and percentage of school attendance were used for evaluation before and after treatment. The therapeutic efficacy was compared between two groups. After 12 weeks, in the CBT group, the SAS score, SDS score and CGI-S score were significantly decreased (p<0.01) and the percentage of school attendance was 72.2%; in the CBT plus Fluoxetine group, the SAS score, SDS score and CGI-S score were significantly decreased (p<0.01) and the percentage of school attendance was 82.1%. There were no significant differences in the SAS score, SDS score, CGI-S score and the percentage of school attendance after 12-week treatment between two groups (p<0.01). Our results demonstrated that the CBT combined Fluoxetine treatment has comparable therapeutic efficacy to CBT alone for SR, but was not superior to CBT alone.
  Timothy E. Audas , Yu Li , Genqing Liang and Rui Lu
  Luman/CREB3 (also called LZIP) is an endoplasmic reticulum (ER)-bound cellular transcription factor. It has been implicated in the mammalian unfolded protein response (UPR), as well as herpes simplex virus reactivation from latency in sensory neurons. Here, we report the identification of a novel Luman recruitment factor (LRF). Like Luman, LRF is a UPR-responsive basic-region leucine zipper protein that is prone to proteasomal degradation. Being a highly unstable protein, LRF interacts with Luman through the leucine zipper region and promotes Luman degradation. LRF was found to recruit the nuclear form of Luman to discrete nuclear foci, which overlap with the nuclear receptor coactivator GRIP1 bodies, and repress the transactivation activity of Luman. Compared to LRF+/+ mouse embryonic fibroblast (MEF) cells, the levels of CHOP, EDEM, and Herp were elevated in LRF–/– MEF cells. We propose that LRF is a negative regulator of the UPR. For Luman, it may represent another level of regulation following Luman proteolytic cleavage on the ER and nuclear translocation. In addition to inducing rapid Luman turnover, LRF may repress the transactivation potential of Luman by sequestering it in the LRF nuclear bodies away from key cofactors (such as HCF-1) that are required for transcriptional activation.
  Liangcheng Chen , Tao Jiang , Xiao Li , Qi Wang , Yu Li , Kevin Marley and Yongqiang Wang
  Early detection of Aspergillus fumigatus (A. fumigatus) may facilitate early diagnosis and prevention of Invasive Aspergillosis (IA) in dairy cows. This study used a nested PCR and real-time quantitative PCR method to measure A. fumigatus in feed, tissue and blood samples collected from domestic dairy farms in China. In total, 396 feed samples from across China including corn, soybean meal, cotton seed meal, wheat mill run, distiller’s dried grains, corn and grass silage and Total Mixed Ration (TMR) were tested. Of these, 95% contained detectable levels of A. fumigatus. Blood and tissue samples from the GI tract of 7 unhealthy cows all tested positive for A. fumigatus. The analytical sensitivity of the PCR method was<1 fg/assay.
  Yu Li , Xiaowu Zhang , Roberto D. Polakiewicz , Tso-Pang Yao and Michael J. Comb
  Nuclear translocation of β-catenin is a hallmark of Wnt signaling and is associated with various cancers. In addition to the canonical Wnt pathway activated by Wnt ligands, growth factors such as epidermal growth factor (EGF) also induce β-catenin dissociation from the adherens junction complex, translocation into the nucleus, and activation of target genes such as c-myc. Here we report that EGF-induced β-catenin nuclear localization and activation of c-myc are dependent on the deacetylase HDAC6. We show that EGF induces HDAC6 translocation to the caveolae membrane and association with β-catenin. HDAC6 deacetylates β-catenin at lysine 49, a site frequently mutated in anaplastic thyroid cancer, and inhibits β-catenin phosphorylation at serine 45. HDAC6 inactivation blocks EGF-induced β-catenin nuclear localization and decreases c-Myc expression, leading to inhibition of tumor cell proliferation. These results suggest that EGF-induced nuclear localization of β-catenin is regulated by HDAC6-dependent deacetylation and provide a new mechanism by which HDAC inhibitors prevent tumor growth.
  Thomas M. Dillon , Margaret Speed Ricci , Chris Vezina , Gregory C. Flynn , Yaoqing Diana Liu , Douglas S. Rehder , Matthew Plant , Brad Henkle , Yu Li , Songpon Deechongkit , Brian Varnum , Jette Wypych , Alain Balland and Pavel V. Bondarenko
  In the accompanying report (Wypych, J., Li, M., Guo, A., Zhang, Z., Martinez, T., Allen, M. J., Fodor, S., Kelner, D. N., Flynn, G. C., Liu, Y. D., Bondarenko, P. V., Ricci, M. S., Dillon, T. M., and Balland, A. (2008) J. Biol. Chem. 283, 16194-16205[Abstract/Free Full Text]), we have identified that the human IgG2 subclass exists as an ensemble of distinct isoforms, designated IgG2-A, -B, and -A/B, which differ by the disulfide connectivity at the hinge region. In this report, we studied the structural and functional properties of the IgG2 disulfide isoforms and compared them to IgG1. Human monoclonal IgG1 and IgG2 antibodies were designed with identical antigen binding regions, specific to interleukin-1 cell surface receptor type 1. In vitro biological activity measurements showed an increased activity of the IgG1 relative to the IgG2 in blocking interleukin-1β ligand from binding to the receptor, suggesting that some of the IgG2 isoforms had lower activity. Under reduction-oxidation conditions, the IgG2 disulfide isoforms converted to IgG2-A when 1 M guanidine was used, whereas IgG2-B was enriched in the absence of guanidine. The relative potency of the antibodies in cell-based assays was: IgG1 > IgG2-A > IgG2 >> IgG2-B. This difference correlated with an increased hydrodynamic radius of IgG2-A relative to IgG2-B, as shown by biophysical characterization. The enrichment of disulfide isoforms and activity studies were extended to additional IgG2 monoclonal antibodies with various antigen targets. All IgG2 antibodies displayed the same disulfide conversion, but only a subset showed activity differences between IgG2-A and IgG2-B. Additionally, the distribution of isoforms was influenced by the light chain type, with IgG2λ composed mostly of IgG2-A. Based on crystal structure analysis, we propose that IgG2 disulfide exchange is caused by the close proximity of several cysteine residues at the hinge and the reactivity of tandem cysteines within the hinge. Furthermore, the IgG2 isoforms were shown to interconvert in whole blood or a "blood-like" environment, thereby suggesting that the in vivo activity of human IgG2 may be dependent on the distribution of isoforms.
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