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Articles by Yu Jiang
Total Records ( 3 ) for Yu Jiang
  Yu Jiang , Hao Ni and Yu Zhang
  Purpose to introduce the status quo of China’s transportation development and performance evaluation of transportation industry and to construct an improved integrated evaluation model. Methodology The demonstration procedures and results are shown through the analysis of the most eminent transport corporations in the Chinese transportation industry. First, Analytic Hierarchy Process, Gray Relation Analysis and Factor Analysis are used in the model. After the test, an integrated evaluation model is conducted based on an Arithmetic Average Model, Borda Model and Copeland Model. The optimal model is selected based on the Spearman Rank Correlation coefficients. Findings The results showed that the benchmarking companies were Tielong Logistics in the railway transport, Beijing Media in the waterway transport and Channel Share in the road transport. The financial performances of the listed companies in road transport were the best. Originality We proposed an integrated evaluation method that improved the evaluation methodology and solved the problem of the one-sidedness in an individual evaluation method and the inconsistency in the multiple evaluation methods. The prior test and the back test of the integrated method indicated that the entire methodology was consistent.
  Shibing Yu , Yu Jiang , Deborah L. Galson , Min Luo , Yumei Lai , Yi Lu , Hong-Jiao Ouyang , Jian Zhang and Guozhi Xiao
  ATF4 (activating transcription factor 4) is an osteoblast-enrichedtranscription factor that regulates terminal osteoblast differentiationand bone formation. ATF4 knock-out mice have reduced bone mass(severe osteoporosis) throughout life. Runx2 (runt-related transcriptionfactor 2) is a runt domain-containing transcription factor thatis essential for bone formation during embryogenesis and postnatallife. In this study, we identified general transcription factorIIAγ (TFIIAγ) as a Runx2-interacting factor in a yeast two-hybridscreen. Immunoprecipitation assays confirmed that TFIIAγ interactswith Runx2 in osteoblasts and when coexpressed in COS-7 cellsor using purified glutathione S-transferase fusion proteins.Chromatin immunoprecipitation assay of MC3T3-E1 (clone MC-4)preosteoblast cells showed that in intact cells TFIIAγ is recruitedto the region of the osteocalcin promoter previously shown tobind Runx2 and ATF4. A small region of Runx2 (amino acids 258–286)was found to be required for TFIIAγ binding. Although TFIIAγ interactswith Runx2, it does not activate Runx2. Instead, TFIIAγ bindsto and activates ATF4. Furthermore, TFIIAγ together with ATF4and Runx2 stimulates osteocalcin promoter activity and endogenousmRNA expression. Small interfering RNA silencing of TFIIAγ markedlyreduces levels of endogenous ATF4 protein and Ocn mRNA in osteoblasticcells. Overexpression of TFIIAγ increases levels of ATF4 protein.Finally, TFIIAγ significantly prevents ATF4 degradation. Thisstudy shows that a general transcription factor, TFIIAγ, facilitatesosteoblast-specific gene expression through interactions withtwo important bone transcription factors ATF4 and Runx2.
  Dongzhu Ma , Xiaochun Bai , Shuguang Guo and Yu Jiang
  The Ras-like small GTPase Rheb is an upstream activator of the mammalian target of rapamycin (mTOR). It has recently been shown that Rheb activates mTOR by binding to its endogenous inhibitor FKBP38 and preventing it from association with mTOR. The interaction of Rheb with FKBP38 is controlled by its guanine nucleotide binding states, which are responsive to growth factor and amino acid conditions. In this study, we show that Rheb interacts with FKBP38 through a section within its switch I region that is equivalent to the effector domain of other Ras-like small GTPases. We find that the ability for Rheb to interact with FKBP38 correlates with its activity for mTOR activation. Our findings suggest that FKBP38 is a bona fide effector of Rheb and that the ability to interact with FKBP38 is important for Rheb as an activator of mTOR.
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