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Articles by Younis Ahmad Hajam
Total Records ( 3 ) for Younis Ahmad Hajam
  Muddasir Basheer , Seema Rai , Hindole Ghosh and Younis Ahmad Hajam
  Background and Objective: Polycystic Ovary Syndrome (PCOS) is very common heterogeneous endocrinologic and metabolic disorder in women of reproductive age which leads to infertility/subfertility. The medications available are associated with so many side effects. Therefore; the current study aimed to elucidate the therapeutic efficacy of seed extract of Tephrosia purpurea (TP) in letrozole induced polycystic ovary syndrome (PCOS) in female rat model. Materials and Methods: Letrozole was administered orally (1 mg kg–1 body weight) for 21 days to induce PCOS condition in female rat model (Rattus norvegicus). Three different doses of ethanolic seed extract were administered to PCOS induced rats orally (100, 200 and 300 mg kg–1) for 28 days. On the completion of experimental period, different parameters were studied viz. ovarian weight, ovarian tissue biochemistry (lipid peroxidation, reduced glutathione and superoxide dismutase), hormone assays (testosterone, estrogen, progesterone, FSH, LH, leptin) and histopathology. Results: Ovarian PCOS-induced female rats revealed significant increase in ovarian weight lipid peroxidation and blood plasma testosterone, luteinizing hormone and follicle stimulating hormone when compared to control group, whereas, there was a reduction in the level of blood plasma estradiol, progesterone leptin and ovarian tissue reduced glutathione and superoxide dismutase activities. The ethanolic seed extract restored the anomalies in biochemical, hormonal and histological parameters suggesting it might be used in the management of PCOS. Conclusion: Therefore, it might be suggested that ethanolic seed extract of Tephrosia purpurea might be used in the management of PCOS.
  Muddasir Basheer , Seema Rai , Hindole Ghosh and Younis Ahmad Hajam
  Background and Objectives: Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrinological and metabolic disorder in women of reproductive age which leads to infertility/subfertility. The present study was commenced to elucidate the therapeutic efficacy of melatonin in the pathogenesis of letrozole induced polycystic ovary syndrome (PCOS) in Wistar rat. Materials and Methods: Letrozole was administered orally (1 mg kg1) to induce PCOS condition in Wistar female rats for a period of 2-3 weeks followed by a dose of melatonin (200 µg/100 g b.wt.) to PCOS induced rats. On the completion of experimental period the level of cytokines and expression level of different receptors was assessed. Results: The PCOs rats showed down regulation in melatonin (MT1 and MT2), estrogen (ER-α) and cytokine (IL-2R and IL-6R) receptors expression and high circulatory level of IL-6 and TNF-α during PCO condition. These anomalies in expression pattern and circulatory level of cytokines were restored following the treatment. Conclusion: Finding of present study showed the role of melatonin supplementation at receptor level and also suggesting a crosstalk between MT1R / MT2R via cytokine IL-2R and IL-6R resulting in modulation of ER-α receptors.
  Younis Ahmad Hajam , Seema Rai , Muddasir Basheer , Hindole Ghosh and Srishti Singh
  Background and Objective: Hyperglycemia is a representative hallmark and risk factor for diabetes and is closely linked to diabetes associated complications. The aim of the present study was to evaluate the therapeutic potential of exogenous melatonin against the streptozotocin induced pancreatic damages in rats. Materials and Methods: Streptozotocin was injected for consecutive 6 days. Diabetes was confirmed by blood glucose measurement after 72 h and on 7th day after injection. Animals having blood glucose level above 250 mg dL1 were considered as diabetic and were administered exogenous melatonin for 4 weeks. Animals were euthanized after last dose, pancreas were dissected out, weighed and fixed in Bouin’s fixative for histology and further tissues were kept at -20°C for biochemistry. Results: Diabetic rats displayed significant increase in lipid peroxidation, but pancreatic weight index, antioxidant system (GSH, SOD and CAT) showed decrease. Melatonin treatment to diabetic rats restored the alteration in physiological and biochemical markers. Results were supported by the histopathological observations, STZ treated pancreas showed damage in islets of langerhans, while as melatonin treated diabetic rats recovered the cellular architecture which inturn normalize the function of the pancreas. Conclusion: Therefore, melatonin might be considered as a molecule to protect the pancreatic damages.
 
 
 
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