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Articles by Yongda Zhao
Total Records ( 2 ) for Yongda Zhao
  Zhihui Hao , Yongda Zhao , Baohan Qu , Haoting Wu , Lihua Hao , Zhaopeng Ding , Fenfang Yang and Yan Li
  The objective of this study was to campare different pharmacokinetic parameters of a locally manufactured (Tulathromycin Injection, CONTINENT, China) and reference (Draxxin, Pfizer, USA) formulation of tulathromycin 2.5 mg injection after intramuscular administration of a single dose. Twelve pigs were randomly allocated to two treatment groups. Blood samples were collected by venipuncture of the jugular vein or anterior vena cava, plasma samples were analyzed by High-Performance Liquid Chromatography (HPLC) with tandem mass spectrometry detection (LC-MS/MS) using ESI. Mean puls or minus Standard Deviation (SD) of peak plasma Concentration (Cmax) Area Under the serum Concentration-time curve (AUC0-t), Area Under the serum Concentration-time curve (AUCinf), serum concentration half-life (t1/2) were 4.32±1.52 and 5.86±1.28 μg mL-1, 3.98±1.63 and 4.24±1.30 μgh mL-1, 4.04±1.67 and 4.65±2.01 μgh mL-1, 83.55±12.84 and 79.25±10.64 h for the locally manufactured (tested) and reference formulation, respectively. The 90% confidence intervals of the mean of the difference between log-transformed values for AUC0-360, AUC0-∞ and Cmax were within the bioequivalence accepted range of 80-125%. The results indicate that tulathromycin was rapidly absorbed, eliminated slowly and highly bioavailable following a single dose which make tulathromycin likely to be effective in swine.
  Zhihui Hao , Yongda Zhao , Haoting Wu , Lihua Hao , Zhaopeng Ding , Fenfang Yang and Baohan Qu
  The aim of the study was to investigated the influence of dietary inclusion of tulathromycin at 5 mg kg-1 die on haematological to provide an experiment support for the clinical use of this drug. Eighteen pigs were randomly allocated to three treatment groups. A further six pigs were left untreated as controls (group NTXL). Tulathromycin was administered twice by the oral route administrations of 5, 15, 25 mg kg-1 B.W. in three treatment groups on the 1st and the 4th day, respectively. Blood samples were taken from all animals on days 1, 17, 14 for serum chemical and hematology evaluation. Weight and temperature were measured from all animals at the same time. Comparisons of mean physical examination parameters between treatment and control groups over the 14 day study period revealed no significant differences (p>0.05). All pigs did not show any signs of discomfort after Premix. Hematology evaluation indicated that comparisons of RBC, WBC, HGB, HCT, MCV, MCH, MCHC and PLT between treatment and control groups also revealed no significant differences (p>0.05). AST, ALT, ALP, ALB, BUN were significantly higher in treated groups when compared with the control group (p<0.05) post-treatment. No significant differences as time goes on suggesting that a slight effect of injury on liver was caused by tulathromycin. The safety of tulathromycin Premix in target animal swine indicated that pigs were administered of 5-25 mg kg-1 B.W. via the oral route satisfied clinicians’ demands.
 
 
 
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