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Articles by Yong Feng
Total Records ( 4 ) for Yong Feng
  Yong Feng , Ji- Chuan Guo and Ji Li
  As is known to all, the inter-cell interference of the cell-edge users in cellular network is serious which deteriorate the quality of communication to a great extent, so this study formulated a distributed, low system overhead linear precoding to solve this problem. It considered the downlink channel of a cellular broadband wireless system where base stations and users are assumed to have at least two antennas each and are scheduled based on fractional frequency reuse. Then, the study introduced a balancing algorithm which helps the adjacent base stations to simultaneously beamform to its own user while still minimizing the interference on the non-intended user. Finally, in this study, it also analyzed the degree of freedom can be achieved in the cellular network. The simulation results showed that this new scheme can improve the performance of the cell-edge user significantly while causing only a mild degradation in the performance of the in-cell users.
  Guang-Zhi He , Yong Feng , Wei-Yi Tian , Ning Qian , Shu-Xuan Deng and Chuan-Wei An
  The objective of this study was to understand populations of Salmonella enteritidis (S. enteritidis) in the internal organs of geese after oral challenge. Researchers conducted serovar-specific Fluorescent Quantitative Real-Time PCR (FQ-PCR) for S. enteritidis to detect the genomic DNA of S. enteritidis in the blood and the internal organs including heart, liver, kidney, duodenum, jejunum, ileum, cecum, the bursa of fabricius, thymus, spleen and harderian gland from geese after oral challenge at different time points. To validate these results, the Indirect Fluorescent Antibody (IFA) technique was employed. The results showed that S. enteritidis was consistently detected in all the samples. Ileum and jejunum were positive at 8 h PI and the last organ to show a positive result was the thymus at 36 h PI. The copy numbers of S. enteritidis DNA in each tissue reached a peak at 24 h and 2nd day PI with the blood, jejunum, ileum, liver and spleen containing higher concentrations than other tissues. However, the number of bacteria started decreasing by 2-3 days and by 6 days, the concentration of S. enteritidis DNA was below the detection limits of the FQ-PCR assay except the spleen. The IFA results were similar to those of the FQ-PCR. This study will help in understanding the pathogenesis of S. enteritidis infection in vivo.
  Guiqing Peng , Yan Yan , Chengliang Zhu , Shiqun Wang , Xiaohong Yan , Lili Lu , Wei Li , Jing Hu , Wei Wei , Yongxin Mu , Yanni Chen , Yong Feng , Rui Gong , Kailang Wu , Fengmin Zhang , Xiaolian Zhang , Ying Zhu and Jianguo Wu
  Borna disease virus (BDV) is one of the infectious agents that causes diseases of the central nervous system in a wide range of vertebrate species and, perhaps, in humans. The phosphoprotein (P) of BDV, an essential cofactor of virus RNA-dependent RNA polymerase, is required for virus replication. In this study, we identified the gamma-aminobutyric acid receptor-associated protein (GABARAP) with functions in neurobiology as one of the viral P protein-interacting cellular factors by using an approach of phage display-based protein-protein interaction analysis. Direct binding between GABARAP and P protein was confirmed by coimmunoprecipitation, protein pull-down, and mammalian two-hybrid analyses. GABARAP originally was identified as a linker between the gamma-aminobutyric acid receptor (GABAR) and the microtubule to regulate receptor trafficking and plays important roles in the regulation of the inhibitory neural transmitter gamma-aminobutyric acid (GABA). We showed that GABARAP colocalizes with P protein in the cells infected with BDV or transfected with the P gene, which resulted in shifting the localization of GABARAP from the cytosol to the nucleus. We further demonstrated that P protein blocks the trafficking of GABAR, a principal GABA-gated ion channel that plays important roles in neural transmission, to the surface of cells infected with BDV or transfected with the P gene. We proposed that during BDV infection, P protein binds to GABARAP, shifts the distribution of GABARAP from the cytoplasm to the nucleus, and disrupts the trafficking of GABARs to the cell membranes, which may result in the inhibition of GABA-induced currents and in the enhancement of hyperactivity and anxiety.
  Guang-Zhi He , Wei-Yi Tian , Yong Feng , Ying Wei and Qian-Song He
  To study the pathogenesis of Salmonella enteritidis in experimentally infected ducks. Researchers used the immunohistochemical localization and histopathological to examine various tissues of ducks following oral infection were investigated. The time course for the appearance of viral antigen and tissue lesions in various tissues was coincidental. The study suggested that the bacteria levels of SE in systemic organs have a close correlation with the progression of disease. The abundance of target lamina propria and lymphoid cells may contribute to the high levels of bacteria infection and replication in lymphoid and intestinal tissues.
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