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Articles by Ying Zhang
Total Records ( 13 ) for Ying Zhang
  Ser Peow Tan , Yan Loi Wong and Ying Zhang
  We study the geometry of right-angled hexagons in the hyperbolic 4-space View the MathML source via Clifford numbers or quaternions. We show how to augment alternate sides of such a hexagon and arbitrarily orient each line and plane involved, so that for the non-augmented sides, we can define quaternion half side-lengths whose angular parts are obtained from half the Euler angles associated to a certain orientation-preserving isometry of the Euclidean 3-space. We also define appropriate complex half side-lengths for the augmented sides of the augmented hexagon. We further explain how to geometrically read off the quaternion half side-lengths for a given oriented, augmented, right-angled hexagon in View the MathML source . Our main result is a set of generalized Delambre–Gauss formulas for oriented, augmented, right-angled hexagons in View the MathML source , involving the quaternion half side-lengths and the complex half side-lengths. We also show in the appendix how the same method gives Delambre–Gauss formulas for oriented right-angled hexagons in View the MathML source , from which the well-known laws of sines and of cosines can be deduced. These formulas generalize the classical Delambre–Gauss formulas for spherical/hyperbolic triangles.
  Ying Zhang
  Problem statement: I investigate the determinants of poster reputation in a user-rewarding reputation system on Thelion!WallStreetPit stock message board. My empirical analyses deal with two hypotheses: First, is a poster`s reputation affected by his/her characteristics at the time the message was posted? Second, is reputation also associated with the characteristics of the stock to which the message refers? Approach: To answer these two questions, I tested two sets of explanatory variables in relation to poster reputation in two fixed-effects panel regressions. Results: First, the poster`s popularity in the community, the poster`s sentiment, information quality not quantity and one day follow-up opinion on the stock all have positive impacts on the poster`s reputation; Second, recommending stocks with high price to earnings ratio and high institutional investors holding percentage reduce the chance of receiving reputation credits while promoting high liquidity stocks did the opposite. Conclusion: This study discarded light on the future construction of a credit-weighted sentiment index should the researchers consider weighing each poster`s sentiment based on its reputation. This study also helped us to build a more effective and better functional reputation system in the future. Finally, findings in this study allowed us to better examine the relationship between sentiment and stock returns in future studies.
  Ismail Tamer Ahmed , Mohamed Mohamed Soliman , Hossam Fouad Attia , Munoz Cuellar Lino , Xu Bo , Ying Zhang and Tadashi Yamamoto
  Eicosapentaenoic Acid (EPA) is an omega-3 fatty acid (polyunsaturated fatty acid) that has pleiotropic effects as hypolipidemic and anti-inflammatory actions. Podocytes injury in the renal glomeruli has been proposed as the crucial mechanism in the development of focal segmental glomerulosclerosis or nephrosis. The effect of EPA on Puromycin aminonucleoside (PAN) induced nephrosis was tested. EPA was administered daily for 28 days at a dose of 1 g kg-1 b.wt. then PAN was injected intravenously at a dose of 6 mg/100 g of body weight followed by EPA for 6 days. PAN nephrosis induced increase in proteinuria, lipid profiles, podocytes proteins expression and immunolocalization. EPA induced decrease in proteinuria and lipid profiles induced by PAN nephrosis. Also, EPA induced significant down-regulation in expression of connexin 43 and synaptopodin. Moreover, EPA induced 50% decrease in glomerular cell adhesion induced by PAN nephrosis. Immunoflerusecnce shows expression of desmin and connexin 43 in rat glomeruli that increased by PAN and decreased by EPA. These findings collectively showed that EPA has reno-protective effect during inflammation.
  Qing-Wei Yang , Cheng Zhen , Song Chen , Ying Zhang , Wei Shen , Shi-Shi Chen and Guang-Rong Huang
  Marine fish processing byproducts were considered as potential good protein resource for producing bioactive peptides by enzymatic hydrolysis. In this study, hydrolysates with high ferrous binding ability were prepared by enzymatic hydrolysis from mackerel (Trachurus japonicus) processing byproducts. In order to get hydrolysates of high ferrous binding ability and degree of hydrolysis, the enzymatic hydrolysis conditions were optimized, including proteases type, hydrolysis time, temperature, pH and enzyme to substrate ratio. The results showed that the hydrolysate by alcalase had the highest ferrous binding ability and degree of hydrolysis, reaching to 9.8 and 49.0%, respectively. The best hydrolysis conditions of alcalase were optimized using response surface methodology to be: pH 9.0, temperature of 50°C, enzyme substrate ratio of 160 mg/100 mL, hydrolysis time of 100 min. The ferrous binding ability and degree of hydrolysis were reached to 48.0 and 45.4%, respectively, at these optimized hydrolysis conditions.
  Limin Meng , Jingyu Hua , Ying Zhang , Zhijiang Xu and Gang Li
  This study presents a novel initial frame synchronization scheme of TD-SCDMA system. This algorithm uses the implicit power transition in the special frame structure and introduces a different power ratio detector comparing with the conventional non-coherent algorithms, which makes it less complicated and more reliable. We verify our algorithm by computer simulations and the results show a good and robust performance in a wide range of signal-to-noise ratios (SNRs).
  Zhixue Wang , Hongyue He , Li Chen and Ying Zhang
  UML activity model is mainly used to model the behaviors of software system and the quality of activity model will influence the quality of software system. But because the UML activity model lacks strictly formal semantics, it is difficult to make formal semantics analysis and checking for activity model. An ontology based method of semantics checking for activity model is proposed. The semantics of activity model is divided into static semantics and dynamic semantics. The static semantics is transformed into OWL DL by an algorithm, and the dynamic semantics is described by DL-Safe rules. Then the consistency of UML activity model is analyzed and some model checking rules are defined, which enables model consistency checking by using an ontology reasoning tool.
  Ying Zhang , Chong Wu and Xin-ying Zhang
  Enterprise financial distress prediction has been the attention focus in the theory study and the business community. To build a scientific, fast and effective model for financial crisis prediction of the Chinese listed companies, 11 key financial indicators are chosen for the financial distress prediction model. The factor analysis is used to extract five common factors and therefore, to get the comprehensive score of each sample. The traditional ST and non-ST classification criteria are abandoned; the score intervals of the enterprise financial status are divided in a novel way-health, concern and distress. Finally, the five common factors are trained and tested as the input and the financial status as the output with the prediction model based on the backpropagation neural network. The result shows that the proposed model is accurate and can provide a great assistance for enterprises, investors and decision-makers.
  Lihong Yang , Ying Zhang and Xuehui Yu
  Background and Objective: Breast cancer are a frequently diagnosed cancer in a female with a high mortality. This cell line study was planned to investigate the chemo protective efficiency of obovatol (OBO) in MCF-7 human breast adenocarcinoma cells. Materials and Methods: The MCF-7 cell treated with various concentrations of OBO (10, 25, 50 and 100 μM) to evaluate the anti-proliferative/ cytotoxicity study by MTT assay, pro-apoptotic activity by assessing caspase-3/9 (apoptotic markers) and protein expression of Bcl2 and Bax as well as cell cycle arresting property (cycle phases) by flow cytometry. Results: The MCF-7 cells supplemented with increased concentration of OBO displayed significant cytotoxicity/anti-proliferative activity with increased DNA fragmentation. Whereas, cell cycle phase analysis revealed considerable cell arrest after the addition of OBO by improving G0/G1and S phase. Moreover, the activities of caspase-3 and 9 were notably increased after treatment with OBO as well as the protein expression of Bax (pro-apoptotic protein) were markedly upregulated with a suppressed protein expression of Bcl2 (anti-apoptotic protein) were noted in MCF-7 administered with OBO in a dose-dependent manner. Conclusion: Overall, OBO showed potent chemopreventive activity by demonstrating its anti-proliferative, apoptosis and cell cycle arrest properties in a concentration-dependent fashion.
  Hao Yan and Ying Zhang
  In P2P, trust is the basic of effective interactions between nodes but because of the anonymity and dynamic characters, it is difficulty to establish and maintain the trust relationships in the network. In fact trust is not objective but has subjectivity and ambiguity, so this study gives a new distributed trust model based on fuzzy sets theory for evaluating the trust values of nodes which considers multiple network factors, different weights, different interaction results and finally proposes a general algorithm for calculating node’s trust. Specifically, this trust model incorporates both direct trust and indirect trust and provides a flexible method to combine the two different parts. At last, by simulations we can see that this trust model can distinguish good nodes and malicious nodes, and give great help for nodes to effectively select appropriate interaction partners.
  Ying Zhang , Mireille N. Vankemmelbeke , Lisa E. Holland , David C. Walker , Richard James and Christopher N. Penfold
  Enzymatic colicins such as colicin E9 (ColE9) bind to BtuB on the cell surface of Escherichia coli and rapidly recruit a second coreceptor, either OmpF or OmpC, through which the N-terminal natively disordered region (NDR) of their translocation domain gains entry into the cell periplasm and interacts with TolB. Previously, we constructed an inactive disulfide-locked mutant ColE9 (ColE9s-s) that binds to BtuB and can be reduced with dithiothreitol (DTT) to synchronize cell killing. By introducing unique enterokinase (EK) cleavage sites in ColE9s-s, we showed that the first 61 residues of the NDR were inaccessible to cleavage when bound to BtuB, whereas an EK cleavage site inserted at residue 82 of the NDR remained accessible. This suggests that most of the NDR is occluded by OmpF shortly after binding to BtuB, whereas the extreme distal region of the NDR is surface exposed before unfolding of the receptor-binding domain occurs. EK cleavage of unique cleavage sites located in the ordered region of the translocation domain or in the distal region of the receptor-binding domain confirmed that these regions of ColE9 remained accessible at the E. coli cell surface. Lack of EK cleavage of the DNase domain of the cell-bound, oxidized ColE9/Im9 complex, and the rapid detection of Alexa Fluor 594-labeled Im9 (Im9AF) in the cell supernatant following treatment of cells with DTT, suggested that immunity release occurred immediately after unfolding of the colicin and was not driven by binding to BtuB.
  En-Jun Gao , Ying Zhang , Lin Lin , Ren-Shu Wang , Lei Dai , Qi Liang , Ming-Chang Zhu , Mei-Lin Wang , Lei Liu , Wen-Xuan He and Yan-Jin Zhang
  Two manganese complexes, [Mn(L1)2(dibe)2](L1) (1) and [Mn(L2)(dibe)2] (2) (where L1 = 2,2′-bipyridine (bipy), L2 = 1,10-phenanthroline (phen)), were synthesized by using a carboxylic acid ligand (dibe = 2,2-dibenzylmalonate acid). The two complexes were characterized using IR, elemental analysis, and X-ray crystallography. Fluorescence analysis indicates that the two complexes can bind to HeLa cell DNA (HC-DNA), and gel electrophoresis assay demonstrates the ability of the complexes to cleave the HC-DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, apoptotic tests demonstrate that these two complexes have apoptotic effects on HeLa cells.
  Ying Zhang , Mingjuan Liao and Maria L. Dufau
  Our previous studies demonstrated that the histone deacetylase inhibitor, trichostatin A (TSA), induces derepression of the human luteinizing hormone receptor (LHR) gene by de-recruitment of the pRB homologue p107 repressor from the promoter in JAR and MCF-7 cancer cells. TSA initiates a mechanism whereby the phosphatidylinositol 3-kinase/protein kinase ζ (PKCζ) cascade phosphorylates Sp1 at Ser-641, which is essential for the release of the repression of LHR transcription. The present studies have revealed that dissociation of serine/threonine protein phosphatases PP2A and PP1 from the LHR promoter mediates TSA-induced activation of LHR gene transcription in a cell-specific manner. Changes in chromatin structure induced by TSA cause the release of PP2A in JAR cells or of PP1 in MCF-7 cells, which is associated with Sp1 directly or through histone deacetylase 1/2, respectively, at the promoter. This favors the phosphorylation of Sp1 mediated by the phosphatidylinositol 3-kinase/PKCζ pathway, which in turn causes the release of the p107 inhibitor from Sp1 and marked transcriptional activation of the LHR. These findings reveal the importance of phosphatases in the control of LHR transcription, where the balance between phosphatidylinositol 3-kinase/PKCζ and phosphatases could be critical for up- and down-regulation of LHR gene expression in physiological and pathological settings.
  Liping Zhang , Ying Zhang and Kelly G. Ten Hagen
  Cell-cell and cell-matrix adhesion are crucial during many stages of eukaryotic development. Here, we provide the first example that mucin-type O-linked glycosylation is involved in a developmentally regulated cell adhesion event in Drosophila melanogaster. Mutations in one member of the evolutionarily conserved family of enzymes that initiates O-linked glycosylation alter epithelial cell adhesion in the Drosophila wing blade. A transposon insertion mutation in pgant3 or RNA interference to pgant3 resulted in blistered wings, a phenotype characteristic of genes involved in integrin-mediated cell interactions. Expression of wild type pgant3 in the mutant background rescued the wing blistering phenotype, whereas expression of another family member (pgant35A) did not, revealing a unique requirement for pgant3. pgant3 mutants displayed reduced O-glycosylation along the basal surface of larval wing imaginal discs, which was restored with wild type pgant3 expression, suggesting that reduced glycosylation of basal proteins is responsible for disruption of adhesion in the adult wing blade. Glycosylation reactions demonstrated that PGANT3 glycosylates certain extracellular matrix (ECM) proteins. Immunoprecipitation experiments revealed that PGANT3 glycosylates tiggrin, an ECM protein known to bind integrin. We propose that this glycosyltransferase is uniquely responsible for glycosylating tiggrin in the wing disc, thus modulating proper cell adhesion through integrin-ECM interactions. This study provides the first evidence for the role of O-glycosylation in a developmentally regulated, integrin-mediated, cell adhesion event and reveals a novel player in wing blade formation during Drosophila development.
 
 
 
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