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Articles by Ying Yi
Total Records ( 2 ) for Ying Yi
  Ya-Dan Hou , Zhi-Fu Guo , Ying Yi , Hui-Nan Li , Hao-Ge Li , Li-Jing Chen , Hui Ma , Li Zhang , Jing-Wei Lin and Ming Zhong
  We investigated the changes in the concentrations of protein, soluble sugar, proline, malondialdehyde and the antioxidative enzyme activities of superoxide dismutase, peroxidase, catalase of three wheat (Triticum aestivum L.) cultivars, DN1, Mironovskaya 808 (M808) and Chinese Spring (CS) under cold stress and exogenous abscisic acid treatment in the growth chamber. The results on physiological indices suggested that DN1 and M808 were higher than that of CS on cold resistance. We also found that abscisic acid had significant impacts on cold resistance, suggesting that low concentration of abscisic acid could improve cold acclimation of wheat under low temperature and the high concentration could inhibit cold acclimation. Therefore, physiological changes in wheat seedlings are useful to better understand chilling stress responses in plants which promise to improve cold resistance of crops at low temperatures.
  Olga Mikhaylova , Monika L. Ignacak , Teresa J. Barankiewicz , Svetlana V. Harbaugh , Ying Yi , Patrick H. Maxwell , Martin Schneider , Katie Van Geyte , Peter Carmeliet , Monica P . Revelo , Michael Wyder , Kenneth D. Greis , Jarek Meller and Maria F. Czyzyk-Krzeska
  Human renal clear cell carcinoma (RCC) is frequently associated with loss of the von Hippel-Lindau (VHL) tumor suppressor (pVHL), which inhibits ubiquitylation and degradation of the alpha subunits of hypoxia-inducible transcription factor. pVHL also ubiquitylates the large subunit of RNA polymerase II, Rpb1, phosphorylated on serine 5 (Ser5) within the C-terminal domain (CTD). A hydroxylated proline 1465 within an LXXLAP motif located N-terminal to the CTD allows the interaction of Rpb1 with pVHL. Here we report that in RCC cells, pVHL regulates expression of Rpb1 and is necessary for low-grade oxidative-stress-induced recruitment of Rpb1 to the DNA-engaged fraction and for its P1465 hydroxylation, phosphorylation, and nondegradative ubiquitylation. Egln-9-type prolyl hydroxylases, PHD1 and PHD2, coimmunoprecipitated with Rpb1 in the chromatin fraction of VHL+ RCC cells in response to oxidative stress, and PHD1 was necessary for P1465 hydroxylation while PHD2 had an inhibitory effect. P1465 hydroxylation was required for oxidative-stress-induced Ser5 phosphorylation of Rpb1. Importantly, overexpression of wild-type Rpb1 stimulated formation of kidney tumors by VHL+ cells, and this effect was abolished by P1465A mutation of Rpb1. These data indicate that through this novel pathway involving P1465 hydroxylation and Ser5 phosphorylation of Rbp1, pVHL may regulate tumor growth.
 
 
 
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