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Articles by Ying Han
Total Records ( 2 ) for Ying Han
  Kun Wang , XiaoTing Chen , RongWei Zhao , QiRui Hao , QiRui Hao , GeFeng Xu , XuYang Jiang and Ying Han
  Researchers cloned the Leptin of Culter alburnus in Xingkai Lake and analyzed the sequence characteristic of Leptin coding protein and detected the relative expression levels of Leptin RNA in wild and cultured Culter alburnus in Xingkai Lake of different ages. The result provide reference on studying the regulatory effect and molecular mechanism of Leptin on food intake, digestion and catabolism genes and in Culter alburnus in Xingkai Lake. The full length cDNA of Leptin gene was got by RT-PCR, 5'-RACE and 3'-RACE. The primer of semi-quantitative RT-PCR and real-time PCR were designed by the acquired cDNA then the gene expression was studied. The full sequence length of Leptin in Culter alburnus in Xingkai Lake was 1208 bp, the ORF length is 522 bp which code 173 amino acids. With the increase of age, the expression of mRNA in both wild and cultured Culter alburnus in Xingkai Lake show rising trend, from 3 years old, the expression of Leptin in wild population showed down regulation in contrast to the cultured population.
  Zailian Lu , Wei Liu , Huizhe Huang , Ying He , Ying Han , Yanning Rui , Yanhai Wang , Qinxi Li , Ka Ruan , Zhiyun Ye , Boon Chuan Low , Anming Meng and Sheng-Cai Lin
  Axin plays an architectural role in many important signaling pathways that control various aspects of development and tumorigenesis, including the Wnt, transforming growth factor-β, MAP kinase pathways, as well as p53 activation cascades. It is encoded by the mouse Fused (Fu) locus; the AxinFu allele is caused by insertion of an IAP transposon. AxinFu/Fu mice display varying phenotypes ranging from embryonic lethality to relatively normal adulthood with kinky tails. However, the protein product(s) has not been identified or characterized. In the present study, we conducted immunoprecipitation using brain extracts from the AxinFu mice with specific antibodies against different regions of Axin and found that a truncated Axin containing amino acids 1–596 (designated as AxinFu-NT) and the full-length complement of Axin (AxinWT) can both be generated from the AxinFu allele. When tested for functionality changes, AxinFu-NT was found to abolish Axin-mediated activation of JNK, which plays a critical role in dorsoventral patterning. Together with a proteomics approach, we found that AxinFu-NT contains a previously uncharacterized dimerization domain and can form a heterodimeric interaction with AxinWT. The AxinFu-NT/AxinWT is not conducive to JNK activation, providing a molecular explanation for the dominant negative effect of AxinFu-NT on JNK activation by wild-type Axin. Importantly, AxinFu-NT exhibits no difference in the inhibition of Wnt signaling compared with AxinWT as determined by reporter gene assays, interaction with key Wnt regulators, and expression of Wnt marker genes in zebrafish embryos, suggesting that altered JNK signaling contributes, at least in part, to the developmental defects seen in AxinFu mice.
 
 
 
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