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Articles by Yi Zhang
Total Records ( 16 ) for Yi Zhang
  Shaoqing Tang , Dongxiao Sun , Jiangtao Ou , Yi Zhang , Guiyun Xu and Yuan Zhang
  Insulin-like growth factors are crucial in cellular growth, differentiation, and reproduction by mediating many of the actions of growth hormone in chickens. To determine whether insulin-like growth factors genes (IGFs) are associated with important economic traits in chicken or not, we herein analyzed the association between two single nucleotide polymorphisms (SNPs) within IGF1 and IGF2 and twenty-seven growth, body measurement, carcass, and reproduction traits in two Chinese native breeds, i.e., Beijing You and Silkies. With marker-trait association analysis, we found that SNP IGF1-PstI, within the 5' flanking region of IGF1, was significantly associated with body weight at 8 (BW8), 10 (BW10), and 13 (BW13) wk of age; and shank length (SL13) and shank circumference (SC13) at 13 wk of age in Silkie population (P < 0.05). The SNP IGF2-MspI within the exon2 of IGF2 showed a significant association with body weight (BW17) and carcass weight (CW17) at 17 wk of age in Beijing You population (P < 0.05). Our findings implied that the SNPs within IGF1 and IGF2 genes could be in linkage disequilibrium with the actual causative mutations that affect growth and carcass traits.
  Jinping Liu , Yi Zhang , Lin Lan , Rui Zhang and Feifei Liu
  Local brand prejudice is a significant and widespread proposition in China. Chinese media play the part of highlighting the local brand quality crisis or activating the local brand bias deliberately or accidentally. This study takes the Chongqing Wal-mart food safety event reported by Chinese media as an example. It makes the text analysis with frame theory on the media frame, subject discourse-power and agenda setting. And it reveals the deficiency of national interest standard and self-consciousness of Chinese media when they reported the negative event of foreign brand. It confirms the framing effect of local brand prejudice formed by Chinese media.
  Yi Zhang , Jinping Liu , Feifei Liu and Lin Lan
  Local brand stereotype is a typical social cognitive bias in China and it has controlled brand attitude and consumption behavior of Chinese consumers. Therefore, how to inhibit local brand stereotype is an important research proposition. This study takes the stimulus information of the ethnocentrism and foreign brand negative information in the Mimicry environment as cognitive clue. Through experiment it finds that the ethnocentrism stimulus information can reinforce the credibility and emphasis of perceiving foreign brand negative information. However, this effect of the adjustment is only notable on the television group. Meanwhile, the ethnocentrism stimulation information has the significant adjustment on reserving abstract local brand stereotype by the foreign brand negative information in the television group. The research shows that the effects of foreign brands negative information disclosure on local brand bias inhibition were regulated by ethnocentric stimulation information. Price and technical content is higher, the adjustment effect is higher.
  Yi Zhang , Jinping Liu , Min Zhou , Feifei Liu , Lin Lan and Rui Zhang
  A large body of evidence has demonstrated that COO stereotype is a typical cognitive bias of Chinese consumers, how to inhibit the stereotype is an important research proposition. This study tends to choose information of two product-related attributes and information of two non-product-related attributes through reports materials of negative information of foreign brands in media in recent years to constitute four experimental groups. It finds that the negative information involving quality and price profiteering is of significant inhibition on quality evaluation, attitude preference and purchase intention of subjects on specific foreign brands while the negative information involving commercial bribery is not of significant inhibition, which shows that the inhibition on specific foreign brand preference by negative information of foreign brands is related to differences of product attributes. The inhibition on subject’s quality evaluation, attitude preference and purchase intention of abstract foreign brands by negative information involving food quality is significantly higher than by information of notebook quality, price profiteering and commercial bribery, which shows food safety is of the highest accessibility. Meanwhile, the quality evaluation, attitude preference and purchase intention of specific foreign brands by subjects are lower than those of specific local brands, which shows a significant inhibition on foreign brand preference and local brand bias by negative information of foreign brands.
  Yi Zhang , Jinping Liu , Lin Lan , Rui Zhang and Feifei Liu
  Business practice shows that brand in essence is a kind of "commitment" which creates value for stakeholders and can get value from it. At present, most researches explore the consumption psychology and behavior from the view of brand loyal (or purchase intention) and pay the less attention to the brand value commitment. Even in the few related studies, they are qualitative ones. Therefore, by virtue of the Organization Commitment Theory and Commitment Foci, this study divides the brand value commitment into Attitude Commitment by the way of organizational behavior and Behavior Commitment by the way of social psychology. Attitude commitment includes organizational commitment, affective commitment, quality commitment, economic commitment and relationship commitment. Behavioral commitment includes purchase commitment, reputation commitment, tolerance commitment and continuance commitment. By questionnaires, this study analyzes the influence of consumer brand attitude commitment on their behavior commitment. And it confirms that consumer brand attitude commitment have a significant positive impact on their purchase commitment, public praise commitment and continuance commitment; while the organizational commitment, affective commitment, quality commitment and relationship commitment have significant positive impacts on consumer brand behavior commitment.
  Ding Zhou , Yi Zhang , Daxi Xue and Ping Liu
  Background and Aim: Cataracts have the highest incidence among eye diseases, particularly blindness. Quercetin as a major flavonoid in the diet, can prevent cataracts. This study was aimed at investigating the molecular mechanism of the protective effects of quercetin in selenium-induced cataracts in Wistar rat. Materials and Methods: Ten-day old Wistar rats were randomly divided into four groups, all treated by intraperitoneal injection with 20 μM kg–1 sodium selenite to induce cataracts. The groups were a model group with no further treatment (A), a heated bath group (B), an Alanine-Glutamine treatment group (1.125 g kg–1; group, C) and a quercetin treatment group (400 mg kg–1, i.p., D). Expression level of HSP70 was determined by quantitative real-time PCR and immunohistochemistry. 8-Hydroxy-2-deoxyguanosine (8-OHdG), superoxide dismutase (SOD) and catalase (CAT) were assessed by ELISA assay. Results: The selenium-induced cataract model in rats was established successfully. The expression level of HSP70 in the groups B and C was significantly higher than that in group A. In contrast, the expression level of HSP70 in group D was significantly lower than that in group A (p<0.05). 8-OHdG levels in lens epithelial cells of group D were significantly lower than those in the cells of group A (p<0.05). CAT and SOD activities were enhanced to a much greater extent in group D than in group A (p<0.05). Conclusion: Quercetin has a protective effect on selenium-induced cataracts and probably modulates the expression of HSP70 to maintain homeostasis of oxidative stress.
  Jun Chen , Yachun Wang , Yi Zhang , Dongxiao Sun and Yuan Zhang
  Bio-economic profit models were used on Chinese Holstein production system to evaluate economic values for production traits Milk Yield (MY), Fat Percentage (FP), Protein Percentage (PP)) growth traits Mature Live Weight (LW) and functional traits Age at First Calving (AFC), Calving Interval (CI), Production Lifetime (PL) and Somatic Cell Count (SCC) traits. Economic and production parameters were derived from large scale dairy farms located in Beijing in 2008 to characterize Chinese Holstein production system, which were described according to their growth stage and levels of feed and management environment. Revenue and cost were calculated according to different age group in dairy production. With a fixed number of cows per herd as a basis of evaluation, two milk payment systems were considered. Under payment system based on milk volume, estimated economic values were RMB 1.99 (MY, kg),-4.72 (PP, %), -8.00 (FP,%), 0 (SCC), -4.96 (AFC, days), 1.71 (CI, days), -2.73 (LW, kg) and 1.58 (PL, days), respectively. Under payment system based on milk composition and quality (fat percentage, Protein Percentage, SCC), changes in the economic values were only observed for PP (64.21), FP (41.24), SCC (-393.88), respectively. Sensitivity of economic values was studied, factors considered included the price of milk, price of beef, price of feed and other production variables. Economic values of MY, PP and FP increased significantly with higher price of milk and the beef price had no effect on the economic values of milk production traits. With higher feed price, the economic value for the grow traits and functional traits increased, but that for milk production traits decreased. In summary, evaluated economical value for different traits showed that production and functional traits would have a positive effect, while growth traits would have a negative effect on profitability of Chinese Holstein production system and price of milk and feed were identified as the main factors influencing profit. The bio-economic profit model constructed for Chinese Holstein breeding system could provide general ideas for breeding goals setting in Chinese dairy breeding system in the future.
  M.A. Alim , D.X. Sun , Yi Zhang and M.O. Faruque
  In genetic analysis, various types of genetic markers such as morphological, chromosomal, biochemical and molecular markers are used in buffalo production. Mainly the molecular markers, (hybridization-based markers and PCR-based markers) have tremendous uses which are capable of pinpointing genes and traits and diversity and evolution at the genetic level. In recent years, the demonstration of genetic polymorphism at the DNA sequence level has provided a large number of marker techniques with variety of applications. Genetic marker is a potential tool to geneticists and breeders to evaluate the existing germplasm and to manipulate it to create animals as desired and needed by the society. Now, genetic marker has brought a new dimension to animal breeding, especially in direct identification of the gene. This review focuses on application of different genetic markers in buffalo production.
  Miao Long , Peng Li , Wenkui Zhang , Xiaobing Li , Yi Zhang , Zhe Wang and Guowen Liu
  Zearalenone (ZEN) can occur in food and feeds impairing farm animal performances and health. In this study, the ability to remove zearalenone by Lactobacillus sp. isolated from rumen was evaluated in vitro. Eight strains isolated from rumen were tested for their abilities to remove zearalenone in MRS liquid medium. The removal rate of these strains ranged from 25.64-69.33%. The highest removing ability of these strains was L. mucosae lm4208. Binding may the mechanism of L. mucosae lm4208 to remove ZEN as no toxin derivatives were observed and removal was not impaired in nonviable bacteria. The ability of removing ZEN by the strain was directly related to the bacterial cell wall structure and composition. Removal was affected by culture time, pH and temperature. Although, removal was decreased in simulated gastric/intestinal fluid, the stain still had the very strong elimination ability. These findings suggest that Lactobacillus sp. from rumen can be exploited as a potential approach of detoxification of ZEN.
  Sujun Zhao , Hongning Wang , Wenqiao Fan , Xin Yang , Anyun Zhang , Bo Zeng and Yi Zhang
  Avian Infectious Bronchitis Virus (IBV) is an avian coronavirus. The Nucleocapsid (N) protein of IBV (IBV-N) is an important structural and functional protein and plays an essential role throughout the virus life cycle. Some cellular proteins may be involved in these complicated processes, little is known about virus host interactions. In this study, host cell proteins that interact with N protein were sought by screening a chicken lung cDNA library using a yeast two-hybrid system assay. IBV-N was shown to interact specifically with chicken Ubiquitin-Conjugating enzyme 9 (cUBC9) which belongs to the ubiquitin-conjugating enzyme family and is an important enzyme in the sumoylation system. Furthermore, the interaction between IBV-N and cUBC9 was confirmed by coimmunoprecipitation. The results of mapping the cUBC9 binding region of IBV-N indicated that N151-230 fragment of IBV-N is responsible for the majority of the binding to cUBC9. This virus-host protein interaction may provide insights into the function of IBV-N and facilitate rational targeting of the viral nucleocapsid protein for the development of structure-based vaccines and antiviral compounds.
  Wen-Qiao Fan , Hong-Ning Wang , Yi Zhang and An-Yun Zhang
  Avian Infectious Bronchitis (IB) is an acute and highly contagious respiratory disease in chickens. To detect the virus in chickens, housekeeping genes were detected by quantitative real-time PCR for the normalization. The aim of study was to identify the most stable housekeeping gene (s) in IBV infection. Five housekeeping genes including 18S rRNA, β-actin, Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH), Glucose-6-Phosphate Dehydrogenase (G6PDH) and Ubiquitin (UB) were investigated in nine tissues: trachea, thymus, liver, spleen, lungs, kidney, pancreas, proventriculus and bursa of Fabricius. The geNorm and Normfinder Software were used to calculate the stability of the candidate genes.
  Ru Cao , Hengbin Wang , Jin He , Hediye Erdjument-Bromage , Paul Tempst and Yi Zhang
  Polycomb group (PcG) proteins are required for maintaining the silent state of the homeotic genes and other important developmental regulators. The silencing function of the PcG proteins has been linked to their intrinsic histone modifying enzymatic activities. The EED-EZH2 complex, containing the core subunits EZH2, EED, SUZ12, and RbAp48, functions as a histone H3K27-specific methyltransferase. Here we describe the identification and characterization of a related EED-EZH2 protein complex which is distinguished from the previous complex by the presence of another PcG protein, hPHF1. Consistent with the ability of hPHF1 to stimulate the enzymatic activity of the core EED-EZH2 complex in vitro, manipulation of mPcl1, the mouse counterpart of hPHF1, in NIH 3T3 cells and cells of the mouse male germ cell line GC1spg results in global alteration of H3K27me2 and H3K27me3 levels and Hox gene expression. Small interfering RNA-mediated knockdown of mPcl1 affects association of the Eed-Ezh2 complex with certain Hox genes, such as HoxA10, as well as Hox gene expression concomitant with an alteration on the H3K27me2 levels of the corresponding promoters. Therefore, our results reveal hPHF1 as a component of a novel EED-EZH2 complex and demonstrate its important role in H3K27 methylation and Hox gene silencing.
  Yi Zhang , Xiao- Ming Li , Yan Feng and Bin-Gui Wang
  Two new phenethyl-α-pyrone derivatives including, isopyrophen (1) and aspergillusol (2), were characterised from the culture extract of Aspergillus niger EN-13, an endophytic fungus isolated from the inner tissue of the marine brown alga Colpomenia sinuosa. In addition, four known compounds, including a phenethyl-α-pyrone derivative (pyrophen, 3) and three cyclodipeptides (4-6), were also isolated and identified. The structures of these compounds were elucidated by spectroscopic methods.
  Xiangdong Lu , Grigoriy I. Kovalev , Hua Chang , Eric Kallin , Geoffrey Knudsen , Li Xia , Nilamadhab Mishra , Phillip Ruiz , En Li , Lishan Su and Yi Zhang
  Dynamic changes in chromatin structure through ATP-dependent remodeling and covalent modifications on histones play important roles in transcription regulation. Among the many chromatin modifiers identified, the NuRD (nucleosome remodeling histone deacetylase) complex is unique because it possesses both nucleosome remodeling and histone deacetylase activities. To understand the biological function of the NuRD complex, we generated a knock-out mouse model of the Mta2 (metastasis-associated protein 2) gene, which encodes a NuRD-specific component. Mta2 null mice exhibited partial embryonic lethality. The surviving mice developed lupus-like autoimmune symptoms including skin lesions, bodyweight loss, glomerulonephritis, liver inflammation, and production of autoantibodies. Transplantation of bone marrow cells from Mta2 null mice recapitulated some of the symptoms including skin lesion and bodyweight loss in the recipient mice. Mta2 null T lymphocytes showed normal development but hyperproliferation upon stimulation, which correlates with hyperinduction of interleukin (IL)-2, IL-4, and interferon (IFN)-γ. T cell hyperproliferation, but not other autoimmune symptoms, was observed in T cell-specific Mta2 knock-out mice. Mta2 null T cells produced more IL-4 and IFN-γ under Th2 activation conditions, but normal levels of IL-4 and IFN-γ under Th1 activation conditions. Furthermore, we found that IL-4 is a direct target gene of Mta2. Our study suggests that Mta2/NuRD is involved in modulating IL-4 and IFN-γ expression in T cell immune responses, and gene expression in non-T cells plays an important role in controlling autoimmunity.

  Francisco J. Sandoval , Yi Zhang and Sanja Roje
  FAD synthetases (EC [EC] ) catalyze biosynthesis of FAD from FMN and ATP. Monofunctional FAD synthetases are known to exist in mammals and yeast; bifunctional enzymes also catalyzing phosphorylation of riboflavin to FMN are known to exist in bacteria. Previously known eukaryotic enzymes with FAD synthetase activity have no sequence similarity to prokaryotic enzymes with riboflavin kinase and FAD synthetase activities. Proteins homologous to bacterial bifunctional FAD synthetases, yet shorter and lacking amino acid motifs at the C terminus, were found by bioinformatic analyses in vascular plant genomes, suggesting that plants contain a type of FAD synthetase previously known to exist only in prokaryotes. The Arabidopsis thaliana genome encodes two of such proteins. Both proteins, which we named AtRibF1 and AtRibF2, carry N-terminal extensions with characteristics of organellar targeting peptides. AtRibF1 and AtRibF2 cDNAs were cloned by reverse transcription-PCR. Only FAD synthetase activity was detected in the recombinant enzymes produced in Escherichia coli. FMN and ATP inhibited both enzymes. Kinetic parameters of AtRibF1 and AtRibF2 for the two substrates were similar. Confocal microscopy of protoplasts transformed with enhanced green fluorescence protein-fused proteins showed that AtRibF1 and AtRibF2 are targeted to plastids. In agreement with subcellular localization to plastids, Percoll-isolated chloroplasts from pea (Pisum sativum) synthesized FAD from imported riboflavin. Riboflavin kinase, FMN hydrolase, and FAD pyrophosphatase activities were detected in Percoll-isolated chloroplasts and mitochondria from pea. We propose from these new findings a model for subcellular distribution of enzymes that synthesize and hydrolyze flavin nucleotides in plants.
  Keisuke Tateishi , Jin He , Olena Taranova , Gaoyang Liang , Ana C. D`Alessio and Yi Zhang
  Increasing evidence suggests that islet cell transplantation for patients with type I diabetes holds great promise for achieving insulin independence. However, the extreme shortage of matched organ donors and the necessity for chronic immunosuppression has made it impossible for this treatment to be used for the general diabetic population. Recent success in generating insulin-secreting islet-like cells from human embryonic stem (ES) cells, in combination with the success in deriving human ES cell-like induced pluripotent stem (iPS) cells from human fibroblasts by defined factors, have raised the possibility that patient-specific insulin-secreting islet-like cells might be derived from somatic cells through cell fate reprogramming using defined factors. Here we confirm that human ES-like iPS cells can be derived from human skin cells by retroviral expression of OCT4, SOX2, c-MYC, and KLF4. Importantly, using a serum-free protocol, we successfully generated insulin-producing islet-like clusters (ILCs) from the iPS cells under feeder-free conditions. We demonstrate that, like human ES cells, skin fibroblast-derived iPS cells have the potential to be differentiated into islet-like clusters through definitive and pancreatic endoderm. The iPS-derived ILCs not only contain C-peptide-positive and glucagon-positive cells but also release C-peptide upon glucose stimulation. Thus, our study provides evidence that insulin-secreting ILCs can be generated from skin fibroblasts, raising the possibility that patient-specific iPS cells could potentially provide a treatment for diabetes in the future.
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