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Articles by Yi Huang
Total Records ( 2 ) for Yi Huang
  Bingqi Duan , Yi Huang and Yuan Chen
  Background and Objective: Clinical application of anesthetics in neonatal or children causes neuronal degeneration. Present study evaluates the neuroprotective effect of barbaloin against anesthetic induced neuronal injured rats and also postulates the possible mechanism of its action. Materials and Methods: Animals on P7 were exposed for 6 h with 30% of oxygen that contain 0.75% of isoflurane and rats were treated with barbaloin 10 and 20 mg kg1, p.o. for the duration of 21 days. Cognitive function was evaluated by using morris water maze (MWM) and level of mediators of inflammation and oxidative stress were estimated in the brain tissue by using enzyme-linked immunosorbent assay (ELISA). Moreover western blot assay was performed for the determination of expression of proteins in the neuronal tissues and apoptosis of neuronal cells were observed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and Fluro Jade B staining. Results: Data of report suggest that barbaloin promotes the cognitive function by MWM and apoptosis of neuronal cells was also found to be reduced in barbaloin treated group than isoflurane (INF) group. There was decrease in the mediators of inflammation and oxidative stress in barbaloin treated group compared to INF group. Moreover western blot assay data reveals that barbaloin ameliorates the altered expression of JNK, ERK-1/2, Bcl-2, PI3K, Akt, BDNF and TrKB proteins in the brain tissues of anesthetic induced neuronal injured rats. Conclusion: Data of the report reveals the protective effect of barbaloin against isoflurane induced neuronal injured rats by regulating BDNF/Bcl-2/PI3K signaling pathway.
  Zhiwu Luo , Yi Huang , Guanghui Wei , Xiaohong Cheng , Marko Prehm and Carsten Tschierske
  Novel amphiphilic block molecules consisting of a rigid 2-phenylthiophene or 5-phenylbithienyl core, with a polar glycerol group attached to the phenyl ring and one or two alkyl chains attached to the thiophene ring on the other side, have been synthesised by using Ni(0) and Pd(0) catalyzed coupling reactions as key steps. The thermotropic and solvent-induced liquid crystalline behaviour of these compounds was investigated by polarising optical microscopy and X-ray diffraction. The influence of the length, number and position of the alkyl chains, and the length of the rigid core, on their mesophase behaviour was investigated. Compounds with one alkyl chain in the terminal 5-position on the thiophene ring form only smectic A phases, compounds with two adjacent alkyl chains attached in the 4- and 5-positions of the thiophene ring exhibit thermotropic columnar mesophases, and those with two long alkyl chains attached to the 3- and 5-positions form columnar LC phases only in the presence of water. Another compound containing the longer 5-phenylbithienyl core unit and two alkyl chains attached in lateral positions to each of the thiophene rings is not mesogenic.
 
 
 
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