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Articles by Yasuhiro Ozeki
Total Records ( 2 ) for Yasuhiro Ozeki
  Sarkar M.A. Kawsar , Sharif Uddin , Mohammad A. Manchur , Yuki Fujii and Yasuhiro Ozeki
  Methyl α-D-glucopyranoside was easily prepared by the treatment of D-glucose with anhydrous methyl alcohol in presence of hydrogen chloride at freezing temperature in good yield. Then N- acetylsulfanilylation of methyl α-D-glucopyranoside has been carried out by the direct method and afforded the 6-O-N-acetylsulfanilyl derivative in an excellent yield. In order to obtain newer products, the 6-O-N-acetylsulfanilyl derivative was further transformed to a series of 2,3,4-tri-O-acyl derivatives containing a wide variety of functionalities in a single molecular framework. The chemical structures of the newly synthesized compounds were elucidated by Fourier Transform Infrared spectroscopy (FTIR), 1H-NMR (Proton nuclear magnetic resonance) spectroscopy elemental and physicochemical properties analysis. All the newly synthesized D-glucose derivatives were tested for their in vitro antibacterial activity against some human pathogenic bacterial strains. The study revealed that a good number of acylated products exhibited promising antibacterial activities. It is expected that the acylated derivatives of D-glucose may be considered as a potential source for developing new and better antibacterial agents against a number of pathogenic organism.
  S. M.A. Kawsar , M. Seraj Uddin , E. Huq , N. Nahar and Yasuhiro Ozeki
  In the present research, attempt was taken to explore the antimicrobial potency of the crude extracts of the Macrotyloma uniflorum plant. The extractives of the plant were subjected to screening for inhibition of microbial growth by the disc diffusion method. The zones of inhibition demonstrated by the dichloromethane, ethyl acetate, 1-butanol and aqueous extracts ranged from 11-16, 10-24, 10-14 and 10-12 mm, respectively at a concentration of 500 μg disc-1. The ethyl acetate extract showed promising antibacterial activities against all the gram-positive and gram-negative bacteria whereas dichloromethane extract showed moderate activities and the 1-butanol and aqueous extracts did not show any significant antimicrobial activities. In addition, the antifungal activities of all the extractives were tested, using the food poisoning technique. Only dichloromethane extract has been proved to be active against all fungi tested with a higher inhibition activity than standard nystatin. The overall results provide promising baseline information for the potential use of the crude extracts from M. uniflorum in the treatment of bacterial and fungal infections.
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