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Articles by Yasser M. Shabana
Total Records ( 3 ) for Yasser M. Shabana
  Ekbal M. Abo-Hashem , Mohamed A. Elwakil , Yasser M. Shabana , Mohamed A. El-Metwally , Ghada El-Kannishy , Rokiah Anwar , Eman Fawzy , Mostafa Elzayat and Narmin Saied
  Background and Objective: The liver is the main metabolic organ, carcinogen-metabolizing liver enzymes are the most important candidates that may influence hepatocarcinogenesis associated with heavy metal overload. This study was aimed at analyzing the genetic pattern regarding the proto-oncogene (L-myc) and the cytochrome (CYP2E1), which are involved in detoxification and oncogenesis, in both HCC patients and controls and to study the likelihood of each genetic pattern to develop HCC in the presence of heavy metals load. Materials and Methods: Total 171 hepatocellular carcinoma patients were included and 143 matched healthy controls in this study. Routine laboratory tests and heavy metals (lead, cadmium, arsenic and mercury) concentration were measured. Genetic polymorphisms was detected by a PCR-RFLP method. Student’s t-test and SPSS software used for statistical analysis. Results: C2 allele and C2 containing genotypes of CYP2E1 showed a significant higher percentage in HCC group (p = <0.001). Distribution of different L-myc genotypes in HCC and control groups showed nonsignificant difference ( p = 0.140). As regards the heavy metals concentration in carriers of different genotypes of both CYP2E1 and L-myc revealed no significant difference except for mercury which reported higher levels with the mutant homozygote genotype of L-myc (p = 0.015). Conclusion: There was no significant association between gene polymorphisms and heavy metal burden within HCC patients. It is also noted that CYP2E1 polymorphisms may increase HCC susceptibility while L-myc gene polymorphism showed non significant difference between HCC patients group and control group.
  El-Sayed A. Fayzalla , Yasser M. Shabana and Nasser S. Mahmoud
  Twenty three isolates of Fusarium oxysporum, eight isolates of Fusarium solani, two isolates of Verticillium dahliae and four isolates of Rhizoctonia solani were isolated from tomato plants showing wilting and root rot symptoms at different localities in Dakahlia governorate, Egypt. These isolates varied in their aggressiveness against tomato plants. The influence of temperature, pH, light regime, sealing culture plates with Parafilm (1-10 layers) and type of media on the growth of two F. oxysporum f. sp. lycopersici (isolates 14 and 19), F. solani, V. dahliae and R. solani were evaluated under laboratory conditions in Petri dishes or in liquid culture. The incubation conditions of 25°C and improved aeration (obtained by not wrapping the culture plates) induced the optimal growth of all fungi tested. Among the culture media tested, potato dextrose agar (PDA) was the best medium for the growth of all fungi tested except for F. oxysporum f. sp. lycopersici (isolate 14) which grew best on lima bean agar. The continuous light induced the best growth for F. oxysporum f. sp. lycopersici (isolate 19), F. solani and R. solani. However, F. oxysporum f. sp. lycopersici (isolate 14) grew best under continuous darkness while diurnal light was the best for V. dahliae growth. In general, pH 8 (initial level) promoted the best growth of all fungi tested (isolate 19 of F. oxysporum f. sp. lycopersici, F. solani, V. dahliae and R. solani) except for F. oxysporum f. sp. lycopersici (isolate 14) which was best grown at pH 9 (initial level).
  Mohamed A. Elwakil , Ekbal M. Abo-Hashem , Yasser M. Shabana , Mohamed A. El-Metwally , Ghada El-Kannishy , Ali M. El-Adl , Rokiah Anwar , Eman Fawzy , Narmin Saied and Mustafa M. El-Zayat
  Background: Liver cancer is a widespread malady in Northern parts of Egypt, in which industrial and municipal heavy metals pollutants contaminate both water and soil used for growing edible field and vegetable crops. Materials and Methods: Case-control studies were carried out in three locations in North Delta region (Dakahlia, Kafr El-Sheikh and Damietta governorates) where lead, cadmium, arsenic and mercury are common pollutants. Clinical examination of 143 HCC patients living in heavy metals-polluted areas and 171 healthy individuals living in relatively clean, non-polluted areas were carried out. The investigation was confirmed by fine needle aspiration cytology, histological examination and alpha-fetoprotein level analysis. Heavy metals assay in blood, plants, soil and water were carried out using the atomic absorption spectrophotometry technique and data were statistically analyzed. Results: Demographic and clinical data of patients with HCC show that levels of heavy metals under investigation (Pb, Cd, As and Hg) were significantly higher in the blood of HCC patients compared to control subjects. Conclusion: Results address a strong correlation between the occurrence of these heavy metals in blood of HCC patients and their levels in irrigation water, soil and edible plants.
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