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Articles by Yang Yu
Total Records ( 6 ) for Yang Yu
  Feng Wen , Xingqiao Wang and Yang Yu
  Multilevel networks methods can speed up the optimal route calculation by preprocessing and pre-computing the original traffic network. This study proposes a Genetic Algorithm based clustering method to construct the multilevel network to improve the existing methods. Three objectives are considered simultaneously including reducing the number of nodes, reducing the number of sections on high level network and reducing the variance between sub-networks. The experimental results show the efficiency of the proposed algorithm in this study.
  Yang Yu , Gong Ping , Feng Yanping , Yang Yongping , Li Shijun , Peng Xiuli and Gong Yanzhang
  Previous studies established the toxicity of busulfan (1, 4-butanediol dimethanesulfonate) suspension in sesame oil or emulsion to Primordial Germ Cells (PGC) and present study examined the survival rate of chicken embryos treated with different dosage of busulfan emulsion (0, 120, 240 360 and 480 μg) then observed the morphology of testes and ovaries at 8.5, 11.5 and 14.5 days. The results showed that low dosage treatment (<120 μg) did not have significant influence (p>0.05) on the survival rate of embryos compared with blank control and medium dosage treatment (240 and 360 μg) significantly reduced the survival rate (p<0.05), the high dosage treatment (480 μg) further reduced the survival rate (p<0.05). The increasing dosage of busulfan has positive correlation with both the death rate of embryos and the abnormal of the morphology structure in testes and ovaries. About <120 μg busulfan treatment is recommended to obtain recipient chick embryo in producing germline chimera.
  Nan Zhou , Jin-Chun Zhang , Yong-Xi Liu , Yang Yu , Yuan Deng , Ling Feng , Wei Qi , Chuan-Fang Wu and Jin-Ku Bao
  Developing multi-target drugs to obtain potentially innovative medicines has become a trend in the treatment of multifactorial diseases. The open-access resources are used by computational biologists to uncover relationships among various datasets for further drug discovery. In this study, researchers systematically analyzed approved retail drugs of China Food and Drug Administration (CFDA) in terms of biological interactions networks and found that CFDA-approved drugs had significant multi-target properties. To determine the features of these drugs and understand their indication on multi-target drug design, researchers computationally built a bipartite graph composed of drugs and target proteins linked by drug-target binary associations. Furthermore, researchers chose 19 drugs whose target numbers were ≥15 and then integrated human Protein-Protein Interactions (PPIs) datasets from DIP, IntAct, BioGRID, MINT and HPRD to generate a human PPIs network to analyze targets of these drugs. Graph theory analysis identified significant nodes including five multi-target drugs and eight drug targets which indicated that some of the CFDA-approved drugs were potentially valuable for the future development of multi-target drugs.
  Yang Yu , Hui-Ping Xu and Chang-Wei Xu
  Recognized as the third observation platform, seafloor observatories enable long term, continuous, real time, all weather and multitask scientific observation and become the most remarkable trend in international marine science and technology. This study is aimed to establish a junction box based gateway middleware prior to the back-end server for diverse seafloor observatory monitoring applications. The design manipulates diverse sensor data with communication and processing balance and also gives reference for representing such kind of middleware in the cyberinfrastructure for seafloor observatories. As considering sensor characteristics of data acquisition and data processing for seafloor observatory monitoring, the proposed junction box based gateway middleware is designed with three bridged function modules including data monitor, transaction executer and network responder, to enable real-time data acquisition, data filtering, data interpretation and visualization, database redundancy and storage and control commands configuration. The cyberinfrastructure representation of the gateway middleware is discussed and designed using service-oriented architectures (SOA) and web services. The middleware is built upon the junction box for two-way communication and interoperation to perform efficient and stable applications. The comprehensive middleware design can be easily utilized for general seafloor observatory sensor network surveillance with expansibility and flexibility.
  Yang Yu , Chao Li , Man Zhao and Xingwang Liu
  In order to study the dynamic characteristics of scroll compressor crankshaft it makes the research of the crankshaft rotor of natural gas scroll compressor and analyzes the displacement and angle of inclination based on modal analysis theory and equation of rotor motion; it also calculates the dynamic coefficients of main shaft bearing and simplifies its using spring-damper system-on the basis of rotor dynamic theory; the prestressed structure modal analysis on scroll compressor crankshaft rotor is made and its vibration performance and mode under the action of the centrifugal force-using finite element analysis through the software ANSYS and at the same time it undertakes modal analyses on crankshaft under different support types and changes the support stiffness of bearing to study its effects on the entire dynamic characteristics of a rotor system. The results indicate that when rigid constraints are applied in the main shaft bearing, rotor of the crankshaft is rigid and its fundamental frequency is far less than first order natural frequency and therefore there is no resonance during working process. Maximum deformation will easily occur at the crank pin and cause substantial effects on scroll compressor’s bearing. We can change the main counterweight’s distance from location of the main bearing to lower crank pin’s deflection. When elastic support is applied in the main shaft bearing, natural frequency of crankshaft rotor is lower compared with rigid constraints and the critical speed of rotation also will be decreased.
  Yang Yu , Ningling Ge , Min Xie , Wenjing Sun , Susan Burlingame , Amy K. Pass , Jed G. Nuchtern , Dekai Zhang , Songbin Fu , Michael D. Schneider , Jia Fan and Jianhua Yang
  TAK1 (transforming growth factor-β-activated kinase 1), a mitogen-activated protein kinase kinase kinase, is activated by various cytokines, including interleukin-1 (IL-1). However, the precise regulation for TAK1 activation at the molecular level is still not fully understood. Here we report that dual phosphorylation of Thr-178 and Thr-184 residues within the kinase activation loop of TAK1 is essential for TAK1-mediated NFκB and AP-1 activation. Once co-overexpressed with TAB1, TAK1 mutant with alanine substitution of these two residues fails to activate IKKβ-mediated NFκB and JNK-mediated AP-1, whereas TAK1 mutant with replacement of these two sites with acidic residues acts like the TAK1 wild type. Consistently, TAK1 mutant with alanine substitution of these two residues severely inhibits IL-1-induced NFκB and AP-1 activities, whereas TAK1 mutant with replacement of these two sites with acidic residues slightly enhances IL-1-induced NFκB and AP-1 activities compared with the TAK1 wild-type. IL-1 induces the phosphorylation of endogenous TAK1 at Thr-178 and Thr-184. Reconstitution of TAK1-deficient mouse embryo fibroblast cells with wild-type TAK1 or a TAK1 mutant containing threonine 178 and 184 to alanine mutations revealed the importance of these two sites in IL-1-mediated IKK-NFκB and JNK-AP-1 activation as well as IL-1-induced IL-6 gene expression. Our finding is the first report that substitution of key serine/threonine residues with acidic residues mimics the phosphorylated state of TAK1 and renders TAK1 active during its induced activation.
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