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Articles by Yang Xiang
Total Records ( 3 ) for Yang Xiang
  Xin Guo , Yang Xiang , Qian Chen and Wei Wei
  A Social network graph shows social interactions and relationships between individuals in a specific social environment, which is very helpful for analyzing social relationships, activities, structures, etc. The author quantized the strengths of social objects’ relationships in social environment using an improved vector space model. Gaussian mixture model was employed to set the threshold for identifying social relationships adaptively and divide social subgroups automatically. According to the threshold, social network graph would be constructed based on performance measures. It is concluded that hidden social relationships can be discovered effectively by using this approach which is very flexible and adaptive for dynamic information feedback mechanism.
  Li Wang and Yang Xiang
  This study is focus on the tangential contact characteristics of a single hemispherical asperity when the asperity deformed in the stages of normal elastic-plastic deformation by the finite element method. The normal elastic-plastic contact characteristics of a single asperity contacted with a rigid flat has been studied by some researchers, but the tangential contact characteristics of them is still missing in the detail. The single asperity finite element model is a 3D finite element solid model in the study of the tangential contact characteristics, it is different the plane finite element model in the study of the normal contact characteristics. The local mesh refinement method is applied to mesh the asperity model, within the elastic deformation of the asperity, the normal contact load and area in the finite element analysis have been compared with the Hertz contact theory, the difference is less than 5%, the asperity 3D finite element model has been verified. For tangential contact analysis, a normal displacement is applied at the pilot node of the rigid flat, the asperity will deformation from the elastic to plastic range. Then hold the deformation state, a tangential force is again applied to the pilot node , the rigid flat will move on the surface of the asperity in the range of the micro-displacement state. Under the different normal displacement, the results shows that linear relationship can be obtained between tangential force and tangential micro-displacement, in the range of about , tangent modulus has not obviously effect on the tangential contact stiffness; In the range of about , tangential contact stiffness increasing with the tangent modulus increasing.
  Yongyu Wang , Vania De Arcangelis , Xiaoguang Gao , Biswarathan Ramani , Yi-sook Jung and Yang Xiang
  Agonist-dependent activation of G protein-coupled receptors induces diversified receptor cellular and signaling properties. Norepinephrine (NE) and epinephrine (Epi) are two endogenous ligands that activate adrenoceptor (AR) signals in a variety of physiological stress responses in animals. Here we use cardiomyocyte contraction rate response to analyze the endogenous β2AR signaling induced by Epi or NE in cardiac tissue. The Epi-activated β2AR induced a rapid contraction rate increase that peaked at 4 min after stimulation. In contrast, the NE-activated β2AR induced a much slower contraction rate increase that peaked at 10 min after stimulation. Whereas both drugs activated β2AR coupling to Gs proteins, only Epi-activated receptors were capable of coupling to Gi proteins. Subsequent studies showed that the Epi-activated β2AR underwent a rapid phosphorylation by G protein-coupled receptor kinase 2 (GRK2) and subsequent dephosphorylation on serine residues 355 and 356, which was critical for sufficient receptor recycling and Gi coupling. In contrast, the NE-activated β2ARs underwent slow GRK2 phosphorylation, receptor internalization and recycling, and failed to couple to Gi. Moreover, inhibiting β2AR phosphorylation by βARK C terminus or dephosphorylation by okadaic acid prevented sufficient recycling and Gi coupling. Together, our data revealed that distinct temporal phosphorylation of β2AR on serine 355 and 356 by GRK2 plays a critical role for dictating receptor cellular events and signaling properties induced by Epi or NE in cardiomyocytes. This study not only helps us understand the endogenous agonist-dependent β2AR signaling in animal heart but also offers an example of how G protein-coupled receptor signaling may be finely regulated by GRK in physiological settings.
 
 
 
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