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Articles by Yang Wang
Total Records ( 7 ) for Yang Wang
  Jingxin Dou , Jingshuang Liu , Yang Wang and Guangying Zhao
  To examine the effects of soil warming on carbon-accumulation and -release processes in the wetland ecosystem, a field-warming experiment was conducted under flooded and unflooded water conditions in the typical meadow Calamagrostis angustifolia (C. angustifolia) (TMC) wetland in the Sanjiang Plain, northeast China. Warming cables were used to simulate soil warming. Warming caused significant increases in aboveground biomass compared with belowground biomass during the growing season, and the enhancement of aboveground biomass increased with plant growth while belowground biomass showed an opposite effect. Significant positive correlation was found between aboveground biomass and 10-20-cm soil NH4+-N content whereas belowground biomass was more significantly correlated with 0-10-cm soil NH4+-N content. Positive linear correlations were found between CO2 and CH4 fluxes and warming-induced changes in liable carbon (LBC) and carbohydrate carbon (CHC) contents. Flooded water conditions tended to increase the accumulation of belowground biomass, NH4+-N content and CH4 fluxes under warming treatment. Soil warming could not only stimulate the carbon-accumulation and -release processes in the TMC wetland ecosystem directly, but also indirectly through the enhancement of nitrogen availability and active carbon contents. The contents of NH4+-N and active carbon could be sensitive indicators for the carbon-process changes in wetland ecosystems under soil warming.
  Pin Chen , Yingyu Liu , Chong Liu , Haoyong Zou , Yang Wang , Wentao Li , Dingren Bi and Qigai He
  The detection of pathogens with decreased susceptibility to antibacterial and elucidating the molecular mechanism of resistance are of epidemiological and clinical interest in animal husbandry. The 21 Haemophilus parasuis clinical isolates and one American Type Culture Collection reference strains of Actinobacillus pleuropneumoniae (ATCC 27090) were screened for susceptibility to nalidixic acid and enrofloxacin by the microdilution methods. The nalidixic acid MICs for all of the isolates were ≥2 μg mL-1 and the enrofloxacin MICs for isolates were ≤8 μg mL-1. In addition, the Quinolone Resistance-Determining Regions (QRDRs) of gyrA and parC of all strains were sequenced. Strains for which nalidixic acid MICs were ≤4.0 μg mL-1 lacked modifications in the QRDRs of GyrA and ParC. In contrast, all strains for which nalidixic acid MICs were ≥8 μg mL-1 exhibited one or more amino acid changes in GyrA and ParC. Mutations in GyrA is the major resistance mechanism of Haemophilus parasuis to nalidixic acid and enrofloxacin.
  Yang Wang , Fan Wang , Li-Juan Wang and Tian-Wei Zhang
  Function orientation plays a very important role in the design of a high-speed railway station. The functions include the passing function, transfer function and commercial function. The qualitative and quantitative analysis methods were used in analyzing the function. According to the high-speed train’s features of high density, less regulation capacity and high punctuality, the numbers of the time for waiting for train’s departure and for gathering passengers were calculated after some parameters were given, the two numbers are decreased, respectively, to 49.1 and 53.2% of the conventional railway passenger station, the passing function should be included in the design of the high-speed railway passenger station. Considering that it is unable to provide a door to door service, a high-speed railway station is often connected by two or more lines and a railway hub with several stations. Thus it is necessary for high-speed railway stations to have convenient and rapid transfer function with other traffic modes, as well as interior transfer in station and railway hubs. The business function improves the revenue and the service standard. Enough spaces for commercial development should be designed to make full use of the superiority of attracting people, commodities and information. Some practical problems should be solved to achieve the three functions.
  Yang Wang , Lijuan Wang , Tianwei Zhang and Qingdong Zhou
  Classification station plays an important role in railway transportation. It faced various possible schemes when marshaling station would be extended. Decision makers were concern to how to choose feasible extension scheme so as to minimize the total investment. Based on the actual development, optimization model of extension of classification station is built. The objective function is to minimize the total investment, subject to three groups: First is the sorting capacity is to meet the demand, second is the utilization of sorting capacity is not too low, the last is the capacity of feasible scheme should e is larger than former. In order to reduce the difficulty of solving model directly, this model is transformed into shortest path model. The specific solution is expounded through an example application. The use area of the model is described in the end. The model can be used in the macro-control by high-level leader. The specific micro-operation can be done in this decision.
  Michael Y. Choi , Anthony I. Romer , Yang Wang , Melissa P. Wu , Susumu Ito , Andrew B. Leiter and Ramesh A. Shivdasani
  Many homeodomain transcription factors function in organogenesis and cell differentiation. The Nkx family illustrates these functions especially well, and the Nkx6 subfamily controls differentiation in the central nervous system and pancreas. Nkx6.3, a recent addition to this subfamily, overlaps Nkx6.1 and Nkx6.2 in expression in the hindbrain and stomach. Nkx6.3 transcripts localize in the epithelium of the most distal stomach region, the antrum and pylorus; expression in the adult intestine is lower and confined to the proximal duodenum. Nkx6.3/ mice develop and grow normally, with a grossly intact stomach and duodenum. These mice show markedly reduced gastrin mRNA, many fewer gastrin-producing (G) cells in the stomach antrum, hypogastrinemia, and increased stomach luminal pH, with a corresponding increase in somatostatin mRNA levels and antral somatostatin-producing (D) cells. They express normal levels of other transcription factors required for gastric endocrine cell differentiation, Pdx1, Pax6, and Ngn3; conversely, Ngn3/ mice, which also show reduced gastrin levels, express Nkx6.3 normally. These studies implicate Nkx6.3 as a selective regulator of G- and D-cell lineages, which are believed to derive from a common progenitor, and suggest that it operates in parallel with Ngn3.
  Hua He , Yang Wang , Xiaolan Guo , Sonal Ramchandani , Jin Ma , Mei-Feng Shen , Dennis A. Garcia , Yibin Deng , Asha S. Multani , Mingjian James You and Sandy Chang
  The Protection of telomeres 1 (POT1) protein is a single-stranded telomere binding protein that is essential for proper maintenance of telomere length. Disruption of POT1 function leads to chromosome instability and loss of cellular viability. Here, we show that targeted deletion of the mouse Pot1b gene results in increased apoptosis in highly proliferative tissues. In the setting of telomerase haploinsufficiency, loss of Pot1b results in depletion of germ cells and complete bone marrow failure due to increased apoptosis, culminating in premature death. Pot1b–/ mTR+/ hematopoietic progenitor and stem cells display markedly reduced survival potential in vitro. Accelerated telomere shortening, increased G overhang and elevated number of chromosome end-to-end fusions that initiate an ATR-dependent DNA damage response were also observed. These results indicate an essential role for Pot1b in the maintenance of genome integrity and the long-term viability of proliferative tissues in the setting of telomerase deficiency. Interestingly, these phenotypes closely resemble those found in the human disease dyskeratosis congenita (DC), an inherited syndrome characterized by bone marrow failure, hyperpigmentation, and nail dystrophy. We anticipate that this mouse will serve as a useful model to further understand the pathophysiology of DC.
  Zhiqiang Lu , Markus H. Beck , Yang Wang , Haobo Jiang and Michael R. Strand
  Some pathogens are capable of suppressing the melanization response of host insects, but the virulence factors responsible are largely unknown. The insect pathogen Microplitis demolitor bracovirus encodes the Egf family of small serine proteinase inhibitors. One family member, Egf1.0, was recently shown to suppress melanization of hemolymph in Manduca sexta in part by inhibiting the enzymatic activity of prophenoloxidase activating proteinase 3 (PAP3). However, other experiments suggested this viral protein suppresses melanization by more than one mechanism. Here we report that Egf1.0 inhibited the amidolytic activity of PAP1 and dose-dependently blocked processing of pro-PAP1 and pro-PAP3. Consistent with its PAP inhibitory activity, Egf1.0 also prevented processing of pro-phenoloxidase, serine proteinase homolog (SPH) 1, and SPH2. Isolation of Egf1.0-protein complexes from plasma indicated that Egf1.0 binds PAPs through its C-terminal repeat domain. Egf1.0 also potentially interacts with SPH2 and two other proteins, ferritin and gloverin, not previously associated with the phenoloxidase cascade. Overall, our results indicate that Egf1.0 is a dual activity PAP inhibitor that strongly suppresses the insect melanization response.
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