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Articles by Yan Feng
Total Records ( 5 ) for Yan Feng
  Xiang Zhang , Yonglong Lu , Yajuan Shi , Chunli Chen , Zhi Yang , Yedan Li and Yan Feng
  The effects of cadmium and the polycyclic aromatic hydrocarbon (PAH) pyrene on the earthworm Eisenia fetida were investigated in contact and soil tests. Metabolic (glutathione-S-transferase, GST) and oxidative (catalase, CAT) stress enzymes were studied as biomarkers in earthworms after 48 hours, 14 days and 28 days. Contact test indicated that cadmium had significant effects on survival and enzyme activities while pyrene influenced neither in the studied concentrations. Induction of CAT and GST in earthworms exposed to cadmium and pyrene in the acute soil test (14 d) revealed the metabolism of these chemicals resulting in the production of reactive oxygen species. After a relatively long period of exposure (28 d), earthworms exposed to pyrene failed to handle the high toxicity and were physiologically damaged, while those exposed to cadmium adapted to the disturbed environment through effective metabolism of the chemical and management of the oxidative stress.
  Alexis Garcia , Melanie M. Ihrig , Rebecca C. Fry , Yan Feng , Sandy Xu , Samuel R. Boutin , Arlin B. Rogers , Suresh Muthupalani , Leona D. Samson and James G. Fox
  Helicobacter hepaticus causes hepatitis in susceptible strains of mice. Previous studies indicated that A/JCr mice are susceptible and C57BL/6NCr mice are resistant to H. hepaticus-induced hepatitis. We used F1 hybrid mice derived from A/J and C57BL/6 matings to investigate their phenotype and determine their hepatic gene expression profile in response to H. hepaticus infection. F1 hybrid mice, as well as parental A/J and C57BL/6 mice, were divided equally into control and H. hepaticus-infected groups and euthanized at 18 months postinoculation. Hepatic lesions were evaluated histologically and the differential hepatic gene expression in F1 mice was determined by microarray-based global gene expression profiling analysis. H. hepaticus-infected parental strains including A/J and C57BL/6 mice, as well as F1 mice, developed significant hepatitis. Overall, hepatocellular carcinomas or dysplastic liver lesions were observed in 69% of H. hepaticus-infected F1 male mice and H. hepaticus was isolated from hepatic tissues of all F1 mice with liver tumors. Liver tumors, characterized by hepatic steatosis, developed in livers with high hepatitis scores. To identify gene expression specific to H. hepaticus-induced hepatitis and progression to hepatocellular carcinoma in F1 mice, a method using comparative group transcriptome analysis was utilized. The canonical pathway most significantly enriched was immunological disease. Fatty acid synthase and steaoryl-coenzyme A desaturase, the two rate-limiting enzymes in lipogenesis, were upregulated in neoplastic relative to dysplastic livers. This study suggests a synergistic interaction between hepatic steatosis and infectious hepatitis leading to hepatocellular carcinoma. The use of AB6F1 and B6AF1 mice, as well as genetically engineered mice, on a C57BL/6 background will allow studies investigating the role of chronic microbial hepatitis and steatohepatitis in the pathogenesis of liver cancer.
  Elizabeth J. Theve , Yan Feng , Koli Taghizadeh , Kathleen S. Cormier , David R. Bell , James G. Fox and Arlin B. Rogers
  Hepatitis B virus (HBV), the leading cause of human hepatocellular carcinoma, is especially virulent in males infected at an early age. Likewise, the murine liver carcinogen Helicobacter hepaticus is most pathogenic in male mice infected before puberty. We used this model to investigate the influence of male sex hormone signaling on infectious hepatitis. Male A/JCr mice were infected with H. hepaticus or vehicle at 4 weeks and randomized into surgical and pharmacologic treatment groups. Interruption of androgen pathways was confirmed by hormone measurements, histopathology, and liver gene and Cyp4a protein expression. Castrated males and those receiving the competitive androgen receptor antagonist flutamide had significantly less severe hepatitis as determined by histologic activity index than intact controls at 4 months. Importantly, the powerful androgen receptor agonist dihydrotestosterone did not promote hepatitis. No effect on hepatitis was evident in males treated with the 5α-reductase inhibitor dutasteride, the peroxisome proliferator-activated receptor-α agonist bezafibrate, or the nonsteroidal anti-inflammatory drug flufenamic acid. Consistent with previous observations of hepatitis-associated liver-gender disruption, transcriptional alterations involved both feminine (cytochrome P450 4a14) and masculine (cytochrome P450 4a12 and trefoil factor 3) genes, as well gender-neutral (H19 fetal liver mRNA, lipocalin 2, and ubiquitin D) genes. Hepatitis was associated with increased unsaturated C18 long-chain fatty acids (oleic acid and linoleic acid) relative to saturated stearic acid. Our results indicate that certain forms of androgen interruption can inhibit H. hepaticus-induced hepatitis in young male mice, whereas androgen receptor agonism does not worsen disease. This raises the possibility of targeted hormonal therapy in young male patients with childhood-acquired HBV.
  Yan Feng , Feng Hou and Yali Li
 

LiV3O8, synthesized from V2O5 and LiOH, by heating of a suspension of V2O5 in a LiOH solution at a low-temperature (100–200 °C), exhibits a high discharge capacity and excellent cyclic stability at a high current density as a cathode material of lithium-ion battery. The charge-discharge curve shows a maximum discharge capacity of 228.6 mAh g-1 at a current density of 150 mA g-1 (0.5 C rate) and the 100 cycles discharge capacity remains 215 mAh g-1. X-ray diffraction indicates the low degree of crystallinity and expanding of inter-plane distance of the LiV3O8 phase, and scanning electronic microscopy reveals the formation of nano-domain structures in the products, which account for the enhanced electrochemical performance. In contrast, the LiV3O8 phase formed at a higher temperature (300 °C) consists of well-developed crystal phases, and coherently, results in a distinct reduction of discharge capacity with cycle numbers. Thus, an enhanced electrochemical performance has been achieved for LiV3O8 by the soft chemical method via a low-temperature heating process.

  Yi Zhang , Xiao- Ming Li , Yan Feng and Bin-Gui Wang
  Two new phenethyl-α-pyrone derivatives including, isopyrophen (1) and aspergillusol (2), were characterised from the culture extract of Aspergillus niger EN-13, an endophytic fungus isolated from the inner tissue of the marine brown alga Colpomenia sinuosa. In addition, four known compounds, including a phenethyl-α-pyrone derivative (pyrophen, 3) and three cyclodipeptides (4-6), were also isolated and identified. The structures of these compounds were elucidated by spectroscopic methods.
 
 
 
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