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Articles by Ya-Li Peng
Total Records ( 2 ) for Ya-Li Peng
  Wei Li , Ya-Hu Gao , Min Chang , Ya-Li Peng , Jia Yao , Ren-Wen Han and Rui Wang
  Neuropeptide S (NPS), a recently identified bioactive peptide, was reported to regulate arousal, anxiety, motoring and feeding behaviors. NPS precursor and NPS receptor mRNA were found in the amygdala, the ventral tegmental area (VTA) and the substantia nigra, the area thought to modulate rewarding properties of drugs. In the present study, we examined the influence of NPS on the rewarding action of morphine, using the unbiased conditioned place preference (CPP) paradigm. Morphine (1, 3 and 6nmol, i.c.v.) induced a significant place preference. For testing the effect of NPS on the acquisition of morphine CPP, mice were given the combination of NPS and morphine on the conditioning days, and without drug treatment on the followed test day. To study the effect of NPS on the expression of morphine CPP, mice received the treatment of saline/morphine on the conditioning days, and NPS on the test day, 15min before the placement in the CPP apparatus. Our results showed that NPS (0.3–10nmol) alone neither induced place preference nor aversion, however, NPS (1 and 3nmol) blocked the acquisition of CPP induced by 3nmol morphine, and acquisition of 6nmol morphine-induced CPP was also reduced by NPS (6 and 10nmol). Moreover, the expression of CPP induced by 6nmol morphine was also inhibited by NPS (0.1, 1 and 10nmol). These results revealed the involvement of NPS in rewarding activities of morphine, and demonstrated the interaction between NPS system and opioid system for the first time.
  Ren-Wen Han , Min Chang , Ya-Li Peng , Lian-yong Qiao , Xin-Qiang Yin , Wei Li and Rui Wang

Neuropeptide S (NPS), the endogenous ligand of NPS receptor (NPSR), regulates many biological functions, including arousal, anxiety, locomotion and food intake. NPSR mRNA is expressed in several regions of central autonomic network through which the brain controls visceromotor and other responses essential for survival. However, the role of NPS/NPSR system in regulating gastrointestinal motor is still unknown. Here, we studied the effects of NPS on distal colonic transit in mice. Intracerebroventricular (i.c.v.) injection of NPS (1–1000 pmol) inhibited fecal pellet output and bead expulsion in a dose-dependent manner. However, intraperitoneal injection of NPS (1000 and 10 000 pmol) did not affect fecal pellet output and bead expulsion. In vitro, NPS (0.1–10 μM) also did not modulate distal colonic contractions. Furthermore, i.c.v. co-administration of [D-Val5]NPS, a pure and potent NPSR antagonist, dose-dependently antagonized the inhibitory effects of NPS on fecal pellet output and bead expulsion. In conclusion, our results firstly indicate that central NPS inhibits distal colonic transit through the activation of central NPSR, which implicate that NPS/NPSR system might be a new target to treat function disorder of distal colon.

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