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Articles by Ya Wang
Total Records ( 2 ) for Ya Wang
  Zhicai Zuo , Hengmin Cui , Xi Peng , Junliang Deng , Jing Fang , Ya Wang and Zhihua Ren
  The objective of this study was to determine cytokine and chemokine microarray profiles in lung and Hilar Nodes (HN) from pigs infected with Actinobacillus Pleuropneumoniae (APP). Twenty pigs were randomly assigned to one of two groups: Control Group (CG) and inoculated with APP (TG). The infected-APP pigs’ lung exhibited significantly (p<0.05) greater levels of chemokines CCL2, CCL20, IL8 and slightly increase levels of chemokines CCL4, CCL5 and CXCL2 while significantly(p<0.05) decrease levels of chemokines CXCL10 and CXCL12. APP infection significantly (p<0.05 or 0.01) stimulated expression of cytokines IL-18, IL-6, TNF, GM-CSF, CASP3, CASP8 and significantly (p< 0.05 or 0.01) suppressed expression of cytokines CD40, IRF1 in lung. Cytokines in infected-APP pigs’ lung, IL-1A, IL-27, IRF3, IL-10 were slightly increased and CASP1, IRF7, IL-12B, IL-2 were slightly decreased. Relative cytokine and chemokine microarray data in HN indicated that APP infection significantly (p<0.05) stimulated expression of cytokine IL-6 and significantly (p<0.05 or 0.01) suppressed expression of cytokines CXCL12, CD40 and CASP1. In conclusion, 26 cytokine and chemokines mRNA expression levels in lung and HN obtained from infected-APP or control swines were elucidated in this study. This research provided evidence that the increased severity of lesions in the infected-APP swines was associated mainly with alterations of cytokine and chemokines microarray profiles, especialy in lung. The changes of all the cytokines in lung and HN can lead stem cells to produce granulocytes (neutrophils, eosinophils and basophils) and monocytes and also promoted neutrophil and macrophages to phagocytose bacterial and foreign antigen at the site of inflammation. Defense function of pig infection with APP was enhanced while immune function was weakened.
  Ya Wang , Jian Shen and Qing He
  three-dimensional hydrodynamic model was developed for the Changjiang Estuary and adjacent coastal sea to study the transport timescale and change of estuarine circulation due to human activates. The model was calibrated with measured tidal current and salinity forced by observed freshwater discharge and tides. The tracer age was introduced to measure the transport timescale and evaluate the influence of the man-made construction on estuarine circulation through a series of numerical experiments under various hydrodynamic conditions. The results show that it takes about 23 and 35 days, respectively, for dissolved substances to be transported from the Xuliujing to the mouth of the Estuary (122°30′ E) under high and low discharge conditions. The transport time increases significantly in the upper portion of the North Passage and the South Passage due to the diversion of the freshwater discharge from the upstream North Channel and the increase of the friction downstream. However, the rate of increasing transport time along the estuary decreases farther towards the mouth of the Estuary, presumably resulting from the enhancement of gravitational circulation. Two major physical mechanisms that contribute to the transport timescale, tide and river discharge are analyzed and quantified. The results indicate that freshwater discharge is one of the dominant factors controlling the transport timescale in the Changjiang Estuary. The man-made construction has a significant impact on both horizontal estuarine circulation and gravitational circulation, which ultimately influences the estuarine transport processes. The transport time increased about 50% by man-made constructions, especially near the turbidity maximum. The simulation results provide useful information for understanding the change of transport process and circulation caused by the man-made construction in the Changjiang Estuary.
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