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Articles by Y.O. Adesiji
Total Records ( 3 ) for Y.O. Adesiji
  O.A. Adeyeba , Y.O. Adesiji and P.O. Omosigho
  Diabetic patients comprise a large proportion of our outpatient population and deserve special attention. To determine the prevalence, the clinical characteristics, risk factors, causative organisms and antimicrobial susceptibility of Urinary Tract Infection (UTI) in diabetic patients. Mid-stream urine samples were obtained from a total of 320 patients attending medical outpatient clinic, University College Hospital, Ibadan and apparently healthy volunteers from February to July 2006. Medical records were also reviewed and the patients were divided into two groups according to the presence or absence of diabetes, Patients that were confirmed to be diabetic were included in the study. Out of 320 midstream urine samples examined, 174(54.3%) were diabetic, out of which 37(21%) had significant bacteruria, these include 23(61.9%) females and 14(38.1%) males while in 146 control healthy volunteers only 7(5%) had significant bacteruria, which accounted for 84(58%) of male and 62(42%) of female within the age range of 20-65. Escherichia coli was the predominant bacterial isolate as a causative agent of urinary tract infection in both diabetics and healthy volunteers The antibiotic sensitivity pattern showed that most islolates were sensitive to ofloxaxin, Gentamycin, Nitrofurantoin, Nalixidic acid, Cotrimaxole and Rocephine while they are resistant to tetracyclines, ampicillins, cefuroxime and ceftazidine. The complications of diabetes are of great importance both financially and in terms of mortality and morbidity, because of frequency and severity of UTI in these groups of patients it is recommended that periodic screening of diabetics patients be undertaken to permit early detection and treatment of assymptomatic bacteruria.
  S.S. Taiwo , B.A. Oyekanmi , Y.O. Adesiji , O.O. Opaleye and O.A. Adeyeba
  The aim of this study is to investigate the antibacterial effects of two plant extracts, Citrus aurantifolia linn (lime) and Tithonia diversifolia poaceae (sunflower) commonly used as traditional medicines in Nigeria. The antibacterial activities of aqueous extracts of these two plants were evaluated using disk diffusion susceptibility testing on 53 fresh human bacterial pathogens isolated in Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria. These isolates included 27 Staphylococcus sp., 15 Escherichia coli, 3 Klebsiella sp., 4 Proteus sp. and 4 Pseudomonas sp. The Mean Zone Diameter (MZD) of inhibitions to 5 無 of Citrus aurantifolia linn extracts are 10, 12, 11, 17 and 16 mm for Staphylococcus sp., E. coli, Klebsiella sp., Proteus sp. and Pseudomonas sp., respectively. The MZD of inhibitions to 5 無 of Tithonia diversifolia poaceae extract are 1, 1, 0, 8 and 0 mm and for 5 痢 ciprofloxacin (control) disk are 29, 19, 20, 25 and 15 mm for these respective organisms. Forty four percent (12 of 27) of the Gram positive and 69% (18 of 26) of the Gram negative pathogens showed Zone Diameter (ZD) of inhibition = 10 mm to 5 無 extract of Citrus aurantifolia linn. Four percent (1 of 27) of the Gram positive and 8% (2 of 26) of the Gram negative pathogens showed ZD of inhibition = 10 mm to 5 無 of Tithonia diversifolia poaceae. In comparison, 93% of the Gram positive (25 of 27) and 65% (17 of 26) of Gram negative pathogens showed zone diameter of inhibition = 10 mm to 5 痢 ciprofloxacin (control disk). When compared to ciprofloxacin, 5 無 extract of Citrus aurantifolia linn possess approximately 33% antistaphylococcal activities of 5 痢 ciprofloxacin and approximately the same activity on the Gram negative bacterial isolates tested (p = 0.2767). However, 5 無 extract of Tithonia diversifolia poaceae does not possess any appreciable antibacterial effect on any of the isolates when compared to 5痢 ciprofloxacin disc (p = 0.0045) or when compared to 5 無 extract of Citrus aurantifolia linn (p = 0.0149). Citrus aurantifolia linn showed promising broad spectrum antibacterial effects on human pathogens.
  Y.O. Adesiji , S.S. Taiwo , D.A. Adekanle , V.O. Oboro , S.A. Fayemiwo and O.O. Opaleye
  Although Bacterial Vaginosis (BV) is increasingly being recognized as a health problem among pregnant women, this entity has not been well studied in our environment. The aim of this study, is to determine the prevalence of BV among pregnant women attending the Antenatal Clinic (ANC) of our hospital and posible effects on pregnancy outcome. All pregnant women attending the ANC of Ladoke Akintola University Teaching Hospital (LAUTECH) between July 2004 and December 2005 with the exception of women with diabetics, pregnancy induced hypertension, sickle cell disease, human immunodeficiency virus infection, obstetric complications or women who have taken antibiotics 2 weeks prior to ANC visit, were prospectively studied. High vaginal swab was collected from each woman at the 1st or 2nd trimester of pregnancy and subjected to wet film microscopy and Gram reaction. BV was diagnosed using the clinical criteria recommended by Amsel et al and Gram stain morphology described by Spiegel. All the women were followed up till delivery to determine outcome of pregnancy. Of the total of 204 pregnant women studied (age range 20-40 years, mean age 28.941±4.214, median age 28.5years), 51 had BV, giving a prevalence of 25%; 48 had BV by both clinical criteria and Gram stain morphology, 2 had BV by clinical criteria alone while 1 had BV by Gram stain morphology alone. The overall agreement between the two methods is 94.1%. The age of women with BV ranged between 22 and 44 years (mean age 28.118±4.299 years). There was no significant difference in the mean age of women with BV and those without BV (p=0.3560). BV was commoner among primigravidae (27/51) than multigravidae (24/51) (p=0.0341). Twelve of 153 (7.84%) women without BV had pre-term deliveries while 9 of 51 (17.65%) with BV had pre-term deliveries (p=0.0614). Primigravidae with BV (6/9) did not significantly had more preterm deliveries than those without BV (3/12) (p=0.4857). The mean birth weight of 3.151±0.5562 kg among women with BV was also not significantly different from the mean birth weight of 3.074±0.4629 kg among women without BV (p=0.5707). Although the prevalence of BV is high among pregnant women in our environment, our study did not demonstrate any significant adverse effect on pregnancy outcome.
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