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Articles by Y.H. Zhang
Total Records ( 3 ) for Y.H. Zhang
  Y. Ma , R.R. Li , F. Hou , Y.H. Zhang , H. Chen , S.Z. Xu , N. Cheng and W.S. Liu
  Angiopoietin-like 4 (ANGPTL4), a member of the angiopoietin-like gene family, encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain which is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. ANGPTL4 is a serum hormone directly involved in regulating angiogenesis, lipid metabolism, glucose metabolism, cancer and metabolic diseases. In this study, Radiation Hybrid (RH) cloning board technique, PCR-SSCP and DNA sequencing methods were employed to map bovine ANGPTL4 gene and examine the single nucleotide polymorphisms (SNPs) at the 3'UTR of this gene in 281 cattle from seven breeds. Here, the bovine ANGPTL4 gene was located between the framework marker CA006 and DIK4204 on BTA7 with a map distance of 2.33 cR to the former and an interval of 8.54 cR to the latter. A novel mutation (NC_007305.3: g.C6640T) was revealed which constructed three genotypes (CC, CT and TT). This locus proved to be significantly associated with Average Daily Gain (ADG), Rib-eye Area (REA), Intramuscular Fat (IMF) (p<0.05) and Beef Performance Index (BPI) (p<0.01) in the analyzed populations. Meanwhile, individuals with genotype TT were significantly higher than those with CC in BPI, ADG and REA while it was reversed for genotype TT and CC in the IMF which proved that bovine ANGPTL4 gene had a positive effect on production traits. Hence, genotype TT and CC could be regarded as molecular markers for BPI, ADG and REA and IMF, respectively.
  Y.L. Dong , W. Liu , Y.M. Gao , R.D. Wu , Y.H. Zhang , H.F. Wang and B. Wei
 

Background: Neural stem cell (NSC) transplantation is a promising tool for restoring the nervous system in a variety of neurodegenerative disorders. The aim of this study was to determine the potential of NSC transplantation as a therapeutic strategy for neuronal replacement of the enteric nervous system of the rectum in an aganglionic rat.

Materials and Methods: Rat central nervous system–derived NSCs (CNS-NSCs) obtained from the cortex of the fetal brain (E16) were transplanted into the benzalkonium chloride (BAC)-induced rat aganglionic rectum. Survival and differentiation of the implanted cells were assessed at 8 weeks posttransplantation using immunostaining and Western blotting. The rectoanal inhibitory reflex (RAIR) was also be measured.

Results: Eight weeks following transplantation, grafted CNS-NSCs differentiated into neurons and glial cells in the aganglionic rectum. The protein expression of neuronal nitric oxide synthase (nNOS) and choline acetyltransferase (ChAT) were significantly increased and the RAIR restored after cell implantation.

Conclusions: CNS-NSC transplantation may provide a viable therapeutic option for disorders of the enteric nervous system.
  T. Chen , H. Xu , H.Q. Wang , Y. Zhao , C.F. Zhu , Y.H. Zhang , M.J. Ji , Y.B. Hua and W.X. Wu
  Severe graft rejection remains an important obstacle in intestinal transplantation. In this study, dendritic cells (DCs) isolated from rat bone marrow were cultured for 5 days, and triptolide applied for 3 more days. The recipient rats were pretreated with donor triptolide-modified or not modified DC. Small bowel transplantation was performed to observed survival times. We demonstrated that triptolide markedly inhibited both the expression of CD80 and MHCII expression on DCs. Triptolide-modified DCs stimulated lower proliferative responses among allogeneic T cells, prolonging the survival of intestinal allografts in rats. These results suggested that pretreatment with triptolide-modified DC prolonged the survival of rat small bowel allografts after transplantation.
 
 
 
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