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Articles by Y.H. Liu
Total Records ( 2 ) for Y.H. Liu
  Z. Zhang , C.Y. Zhang , J.P. Guo , L.X. Zhu , X.Y. Luo , R. Wang and Y.H. Liu
  The systemic bioavailability and lung tissue distribution of valnemulin were investigated in swine. About 65 pigs received 10 mg kg-1 body weight of valnemulin by either intravenous (i.v.) or oral (p.o.) route in two studies: study A (10 pigs, i.v. or p.o.) and study B (55 pigs, p.o.). The plasma and lung tissue concentration of the drug were determined by a validated HPLC-MS/MS method. Plasma concentration-time data after i.v. administration (10 mg kg-1 b.w.) were best described by a two-compartment open model. The pharmacokinetic parameters were elimination rate (ke) 0.95±0.17 h-1, the maximum concentrations 4.63±0.66 μg mL-1, area under the plasma concentration-time curve (AUCinf) 5.30±0.37 (h*μg) mL-1. On the other hand, A one-compartment model with a 1st order absorption rate was best fitted to the plasma concentration-time curve of valnemulin after oral administration (10 mg kg-1 b.w.) and the absorption rate (ka) was 0.34±0.03 h-1, the elimination rate (ke) was 1.05±0.19 h-1, the maximum concentration was 0.59±0.08 μg mL-1 at 1.98±0.21 h (tmax), the mean p.o. bioavailability (F) was 57.43%. Following p.o. administration, a mean valnemulin concentration of 0.14 μg g-1 was detected in lung tissue at 36 h postdosing. The lung AUCinf (410.16 h*μg g-1) was 77.39 times higher than the corresponding plasma AUCinf (5.30 h*μg g-1). The apparent elimination half-time for valnemulin in lung was 3.57 h. The advisable bioavailability and extensive distribution to lung tissue following a single dose of valnemulin may be desirable pharmacokinetic attributes for an antimicrobial drug used for the treatment and prevention of respiratory disease in swine.
  A.Y. Abdullahi , J.J. Zuo , H.Z. Tan , W.G. Xia , S. Wei , J.H. Liu , Q. Ai , S.Y. Zhao , M.H. Xia , Y.H. Liu , C.D. Xia , F. Wu , J.P. Yu and D.Y. Feng
  Six hundred and forty, 1 day old Yellow feather broiler chicks were fed wheat-corn soybean diet plus xylanase ENOLZYMETM 100 g ton-1 (enzyme activity = 1256.244 U mL-1) to study additive effect of the enzyme on serum glucose and IGF-1 concentration relative to performance. The birds were randomly divided into 2 treatment groups with 64 birds/pen in 5 replicates. For the periods of 63 days body weight, feed efficiency and daily feed intake were not differed at 21 and 42 days. However, they were all differ significantly at 63 days (p<0.05); particularly feed efficiency from 1-63 days was highly significant (p<0.01). Carcass characteristics were not differed in all three stages but at finishing stage breast and thigh muscles, heart, gizzard and abdominal fat weights were numerically increased. Mortality rate was <0.02%. Serum glucose concentration levels at three feeding phases were not differed among groups. However, serum IGF-1 differ significantly at starter phase (21 days) (p<0.05). Correlation between treatments and feeding periods existed at growing (42 days) and finishing (63 days) stages (p<0.05). The present findings on supplementation of xylanase to corn wheat soy bean broiler diet hasincreased market weight cost value by 1.33% at finishing stage (43-63 days). The serum glucose and IGF-1 concentration have correlated positively on treatments offered, feeding periods and performance. Further research is needed on IGF-1 and GH (Growth Hormone) at molecular level to understand their influence in broiler’s growth and development.
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