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Articles by Y. Yang
Total Records ( 7 ) for Y. Yang
  L.J. Hou , M. Liu , Y. Yang , D.N. Ou , X. Lin , H. Chen and S.Y. Xu
  In order to better understand P cycling and bioavailability in the intertidal system of the Yangtze Estuary, both surface (0–5 cm) and core (30 cm long) sediments were collected and sequentially extracted to analyze the solid-phase reservoirs of sedimentary P: loosely sorbed P; Fe-bound P; authigenic P; detrital P; and organic P. The total sedimentary P in surface and core sediments ranged from 14.58–36.81 μmol g−1 and 17.11–24.55 μmol g−1, respectively, and was dominated by inorganic P. The average percentage of each fraction of P in surface sediments followed the sequence: detrital P (54.9%) > Fe-bound P (23.7%) > organic P (14.3%) > authigenic P (6.3%) > loosely sorbed P (0.8%), whereas in core sediments it followed the sequence: detrital P (61.7%) > Fe-bound P (17.0%) > authigenic P (13.1%) > organic P (7.5%) > loosely sorbed P (0.7%). Post-depositional reorganization of P was observed in both surface and core sediments, converting organic P and Fe-bound P to authigenic P. The accumulation rates and burial efficiencies of the total P in the intertidal area ranged from 118.70–904.98 μmol cm−2 a−1 and 80.29–88.11%, respectively. High burial efficiency of the total P is likely related to the high percentage of detrital P and the high sediment accumulation rate. In addition, the bioavailable P represented a significant proportion of the sedimentary P pool, which on average accounted for 37.4% and 25.1% of the total P in surface and core sediments, respectively. This result indicates that the tidal sediment is a potential internal source of P for this P-limiting estuarine ecosystem.
  This study was to assess effects of the pretreatment in all-plant based diets with microbial phytase on phosphorous utilization and growth performance of Nile tilapia (Oreochromis niloticus). Pretreatment trials were conducted using phytase at graded doses to determine the optimal dose of phytase. Available phosphorus (P) levels increased significantly with the increased doses of phytase and the dose of 1000Ukg−1 was most efficient. Based on the pretreatment trials, plant based diets for Nile tilapia were formulated by pretreating with phytase at 1000Ukg−1. Experimental diets were supplemented with graded levels of mono calcium phosphate (MCP) at 25, 18.75, 12.5, 6.25 and 0gkg −1 diet. In addition, there were three controls: one phytase control, one inorganic P control and one pretreatment control. The results showed that diets pretreated with phytase gave better growth performance, feed conversion ratio and protein efficiency ratio of Nile tilapia compared with the phytase control diet and pretreatment control diet (P<0.05). There were no significant differences in growth performance of Nile tilapia between the inorganic control diet and phytase pretreated diets supplemented with MCP at 25, 18.75 and 12.5gkg−1 (P>0.05), which resulted in significantly better performance than those at 6.25 and 0gkg−1 (P<0.05). Dietary interaction effects of phytase were observed for phosphorus retention efficiency and phosphorus load. Apparent digestibility coefficient of P (ADCp) was improved significantly by phytase pretreatment (P<0.05). No significant difference was detected on ADC of crude protein among all experimental diets (P>0.05).

  Y. Yang , X. R. Zhu , Q. G. Xu , H. Metcalfe , Z. C. Wang and J. K. Yang
  Aims  To assess the efficacy of using magnetic resonance imaging measurements of retinal oxygenation response to detect early diabetic retinopathy in patients with Type 2 diabetes.

Methods  Magnetic resonance imaging was conducted during 100% oxygen inhalation in patients with Type 2 diabetes with either no diabetic retinopathy (n = 12) or mild to moderate background diabetic retinopathy (n = 12), as well as in healthy control subjects (n = 12). Meanwhile, changes in retinal oxygenation response were measured.

Results  In the healthy control group, levels of retinal oxygenation response increased slowly during 100% oxygen inhalation. In contrast, they increased more quickly and attained homeostasis much earlier in the groups with background diabetic retinopathy (at the 20-min time point) and with no diabetic retinopathy (at the 25-min time point) than in the healthy control group (at the 42-min time point). Furthermore, levels of retinal oxygenation response in the group with background diabetic retinopathy increased more than that of the group with no diabetic retinopathy, which in turn increased more than that of the healthy control group. There are statistically significant differences between the group with background diabetic retinopathy and the healthy control group at 6-, 8-, 10-, 15-, 20- and 25-min time points (P < 0.05). According to the normal range of the healthy control group by setting fundus photography results as ‘gold standard’ in our research, the sensitivity, specificity, positive predictive value, negative predictive value and receiver operating characteristic area for reporting the early indications of utility of diabetic retinopathy were 83.33%, 58.33%, 50%, 87.5% and 0.774, respectively.

Conclusions  The results indicate that magnetic resonance imaging is a potential screening method and probably a quantitative physiological biomarker to find early diabetic retinopathy in patients with Type 2 diabetes.

  Z. Pei , X. Chen , C. Sun , H. Du , H. Wei , W. Song , Y. Yang , M. Zhang , W. Lu , R. Cheng and F. Luo


To examine single nucleotide polymorphisms in the protein tyrosine phosphatase N22 gene (PTPN22) and to study their association with Type 1 diabetes in a Chinese cohort.


Three hundred and sixty-four young patients with Type 1 diabetes and 719 healthy children were included in this case-controlled study. The genotypes of rs1217385, rs2488457 (-1123C>G), rs1217414, rs1217419, rs3765598 and rs2476601 (1858C>T) in the PTPN22 gene were determined using the SNaPshot method. Alleles, genotypes and haplotype frequencies were compared between patients with Type 1 diabetes and healthy control subjects. The association between single nucleotide polymorphisms and clinical traits/autoantibody status was also analysed.


The single nucleotide polymorphism, rs1217419, located in the second intron of the PTPN22 gene was associated with Type 1 diabetes (odds ratio 1.5, 95% CI 1.14-1.97, P = 0.003). An additional single nucleotide polymorphism, rs1217385, was also associated with Type 1 diabetes; however, the association was secondary to that of rs1217419. The previously reported single nucleotide polymorphism that is associated with Type 1 diabetes (-1123G>C) had only marginal association with Type 1 diabetes in our study. A marginal association was also identified between -1123G>C and glutamic acid decarboxylase autoantibody positivity in patients with Type 1 diabetes. There was no association between the single nucleotide polymorphism 1858C>T and Type 1 diabetes in our studied cohort.


Our study confirmed that PTPN22 is a gene that contributes to Type 1 diabetes susceptibility. The primary association occurs with single nucleotide polymorphism rs1217419 and there is clear heterogeneity of the association between PTPTN22 polymorphisms and Type 1 diabetes in a Chinese population compared with other populations.

  M. M. K Muqit , Y. Yang , H. Lipinski and V. Chong
  Not available
  X. Zhou , Y. Yang , H. Shan and Z. Wang
  In this study, we consider the design of a network coded non-orthogonal interleave-division multiple-access (IDMA) user cooperation system. Based on eXclusive OR (XOR) operation at relays, the source messages are re-transmitted forward to the destination simultaneously. At destination, a network coding aided iterative Multi-User Detection (MUD) scheme is proposed. And, a multi-user soft network decoding algorithm is developed. Over Nakagami-m fading channels, we examine the BER performance of the proposed network coded cooperative (NetCC) IDMA scheme in various scenarios. Simulation results confirm that NetCC IDMA scheme can provide significant BER improvement compared to the existing IDMA scheme. In addition, based on the EXtrinsic Information Transfer (EXIT) chart technique, the convergence behavior of NetCC IDMA scheme is studied. Simulations also reveal that the proposed scheme can support more users than existing IDMA scheme.
  P. Gong , Y.Z. Gong , Y.P. Yang , Y. Yang , Y.P. Feng , S.J. Li and X.L. Peng
  Sex in birds is determined genetically as in mammals and a Z-linked gene DMRT1 is required for testis development. But it remains possible that the W chromosome contains a similarly critical factor for female development. The W-linked gene PKCIW was put forward as the seductive candidate for avian sex determination and/or sex differentiation. Mis-expression and over-expression of PKCIW were performed respectively in male and female chicken embryo fibroblast with tet-on inducible expression system in this study. The results of RT-PCR showed that with the PKCIW recombinant vector introducing, PKCIW mRNA expression was significantly improved in female chicken embryo fibroblast and was close to that of the female controls and in male chicken embryo fibroblast, in which normally there was no expression. Both mis- and over-expression of PKCIW led to up-regulated expression of P450arom and down-regulated expression of AMH, while large increase of P450arom in female and large decrease of AMH in male appeared. With mis- and over-expression of PKCIW, there was no significant change of FOXL2, SOX9, DMRT1 and ATP5A1W mRNA expression. These results showed the possible regulatory effect of PKCIW on AMH and P450arom in transcription level.
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